pd 98059 has been researched along with Glioblastoma in 20 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously demonstrated that sulforaphane (SFN) inhibited invasion via sustained activation of ERK1/2 in human glioblastoma cells." | 7.85 | Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells. ( Geng, Y; Hu, Y; Lin, K; Tian, H; Wu, S; Wu, W; Yang, G; Zhou, Y, 2017) |
| "Sulforaphane (SFN) was demonstrated to inhibit cell growth in a variety of tumors." | 5.40 | Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells. ( Du, L; Li, C; Niu, J; Peng, X; Tian, H; Wu, W; Yang, G; Zhou, Y, 2014) |
| "The sanguinarine treatment induced the proteolytic activation of caspases and ICAD/DFF45, which was associated with the modulation of the Bcl-2 family, concomitant degradation of poly(ADP ribose) polymerase and phospholipase C-gamma1 protein, and DNA fragmentation." | 5.34 | Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt. ( Choi, BT; Choi, YH; Han, MH; Kim, GY; Kim, SO; Kwon, TK; Lee, WH, 2007) |
| "We previously demonstrated that sulforaphane (SFN) inhibited invasion via sustained activation of ERK1/2 in human glioblastoma cells." | 3.85 | Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells. ( Geng, Y; Hu, Y; Lin, K; Tian, H; Wu, S; Wu, W; Yang, G; Zhou, Y, 2017) |
| " Treating human glioblastoma cells with HGF followed by the topoisomerase inhibitor camptothecin was found to increase the activity per cell of the mitochondrial respiratory chain enzyme succinate-tetrazolium reductase (>80% increase, p < 0." | 3.73 | Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells. ( Laterra, J; Xia, S, 2006) |
| "Sulforaphane (SFN) was demonstrated to inhibit cell growth in a variety of tumors." | 1.40 | Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells. ( Du, L; Li, C; Niu, J; Peng, X; Tian, H; Wu, W; Yang, G; Zhou, Y, 2014) |
| "The sanguinarine treatment induced the proteolytic activation of caspases and ICAD/DFF45, which was associated with the modulation of the Bcl-2 family, concomitant degradation of poly(ADP ribose) polymerase and phospholipase C-gamma1 protein, and DNA fragmentation." | 1.34 | Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt. ( Choi, BT; Choi, YH; Han, MH; Kim, GY; Kim, SO; Kwon, TK; Lee, WH, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (65.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xue, LP | 1 |
| Lu, B | 1 |
| Gao, BB | 1 |
| Shi, YY | 1 |
| Xu, JQ | 1 |
| Yang, R | 1 |
| Xu, B | 1 |
| Ding, P | 1 |
| Wu, S | 1 |
| Zhou, Y | 2 |
| Yang, G | 2 |
| Tian, H | 2 |
| Geng, Y | 1 |
| Hu, Y | 1 |
| Lin, K | 1 |
| Wu, W | 3 |
| Wang, H | 1 |
| Guan, Q | 1 |
| Nan, Y | 1 |
| Ma, Q | 1 |
| Zhong, Y | 1 |
| Li, C | 2 |
| Peng, X | 1 |
| Du, L | 2 |
| Niu, J | 1 |
| Zhu, TZ | 1 |
| Li, XM | 1 |
| Luo, LH | 1 |
| Xu, YH | 1 |
| Cao, P | 1 |
| Liu, Y | 1 |
| Liang, GB | 1 |
| Tencheva, TsS | 2 |
| Panov, IR | 2 |
| Kambe, A | 2 |
| Yoshioka, H | 1 |
| Kamitani, H | 2 |
| Watanabe, T | 2 |
| Baek, SJ | 1 |
| Eling, TE | 2 |
| Soletti, RC | 1 |
| Alves, T | 1 |
| Vernal, J | 1 |
| Terenzi, H | 1 |
| Anderluh, G | 1 |
| Borges, HL | 1 |
| Gabilan, NH | 1 |
| Moura-Neto, V | 1 |
| Li, Z | 1 |
| Klingler-Hoffmann, M | 1 |
| Bukczynska, P | 1 |
| Tiganis, T | 1 |
| Yanamandra, N | 1 |
| Gumidyala, KV | 1 |
| Waldron, KG | 1 |
| Gujrati, M | 1 |
| Olivero, WC | 1 |
| Dinh, DH | 1 |
| Rao, JS | 1 |
| Mohanam, S | 1 |
| Zhan, Y | 1 |
| O'Rourke, DM | 1 |
| Xia, S | 1 |
| Laterra, J | 1 |
| Fioretti, B | 1 |
| Castigli, E | 2 |
| Micheli, MR | 1 |
| Bova, R | 1 |
| Sciaccaluga, M | 1 |
| Harper, A | 1 |
| Franciolini, F | 1 |
| Catacuzzeno, L | 1 |
| Han, MH | 1 |
| Kim, SO | 1 |
| Kim, GY | 1 |
| Kwon, TK | 1 |
| Choi, BT | 1 |
| Lee, WH | 1 |
| Choi, YH | 1 |
| Iguchi, G | 1 |
| Moon, Y | 1 |
| Arcuri, C | 1 |
| Giovagnoli, L | 2 |
| Luciani, R | 1 |
| Secca, T | 1 |
| Gianfranceschi, GL | 1 |
| Bocchini, V | 1 |
| Funakoshi, M | 1 |
| Tago, K | 1 |
| Sonoda, Y | 1 |
| Tominaga , S | 1 |
| Kasahara, T | 1 |
| Park, JS | 1 |
| Qiao, L | 1 |
| Su, ZZ | 1 |
| Hinman, D | 1 |
| Willoughby, K | 1 |
| McKinstry, R | 1 |
| Yacoub, A | 1 |
| Duigou, GJ | 1 |
| Young, CS | 1 |
| Grant, S | 1 |
| Hagan, MP | 1 |
| Ellis, E | 1 |
| Fisher, PB | 1 |
| Dent, P | 1 |
20 other studies available for pd 98059 and Glioblastoma
| Article | Year |
|---|---|
Overexpression of Tripartite Motif-Containing 48 (TRIM48) Inhibits Growth of Human Glioblastoma Cells by Suppressing Extracellular Signal Regulated Kinase 1/2 (ERK1/2) Pathway.
Topics: Carrier Proteins; Cell Cycle; Cell Cycle Checkpoints; Cell Division; Cell Line, Tumor; Cell Prolifer | 2019 |
Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells.
Topics: Apoptosis; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine | 2017 |
Overexpression of human MX2 gene suppresses cell proliferation, migration, and invasion via ERK/P38/NF-κB pathway in glioblastoma cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Fla | 2019 |
Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells.
Topics: Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Res | 2014 |
β-Elemene inhibits proliferation through crosstalk between glia maturation factor β and extracellular signal‑regulated kinase 1/2 and impairs drug resistance to temozolomide in glioblastoma cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcuma; Dac | 2014 |
Intracerebral development of transplanted glioblastoma C6 cells in rats after preliminary exposure to neuropeptides and an MAPK inhibitor.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cell Prolife | 2008 |
The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells.
Topics: Activating Transcription Factor 3; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain | 2009 |
Inhibition of MAPK/ERK, PKC and CaMKII signaling blocks cytolysin-induced human glioma cell death.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Line, Tumor; Cnidarian | 2010 |
Human chorionic gonadotropin β induces cell motility via ERK1/2 and MMP-2 activation in human glioblastoma U87MG cells.
Topics: Cell Line, Tumor; Cell Movement; Chorionic Gonadotropin, beta Subunit, Human; Dose-Response Relation | 2013 |
Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.
Topics: Agar; Androstadienes; Animals; Blotting, Western; Cell Cycle; Cell Division; Cell Separation; Dogs; | 2003 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; | 2004 |
SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival.
Topics: Brain Neoplasms; Cell Line, Tumor; Chromones; Enzyme Activation; ErbB Receptors; Flavonoids; Gliobla | 2004 |
Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells.
Topics: Camptothecin; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Flo | 2006 |
Expression and modulation of the intermediate- conductance Ca2+-activated K+ channel in glioblastoma GL-15 cells.
Topics: Cell Differentiation; Cell Line, Tumor; Flavonoids; Gene Expression; Glioblastoma; Humans; Immunoblo | 2006 |
Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt.
Topics: Alkaloids; Animals; Annexin A5; Apoptosis; Benzophenanthridines; Blotting, Western; Caspases; Cell L | 2007 |
Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.
Topics: Antineoplastic Agents; Astrocytoma; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; | 2008 |
[Intracerebral progression of the transplanted rat C6 glioblastoma cells pretreated with neuropeptides and MAPK inhibitor].
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Brain Neoplasms; Cell Line, Tu | 2007 |
Interleukin-1beta induces apoptosis in GL15 glioblastoma-derived human cell line.
Topics: Antigens, Polyomavirus Transforming; Apoptosis; Brain Neoplasms; Cytoskeleton; DNA Fragmentation; En | 2000 |
A MEK inhibitor, PD98059 enhances IL-1-induced NF-kappaB activation by the enhanced and sustained degradation of IkappaBalpha.
Topics: Binding, Competitive; Cysteine Endopeptidases; DNA; DNA-Binding Proteins; Dose-Response Relationship | 2001 |
Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antigens, Differentiation; Apoptosis; Astrocytes; Cell Sur | 2001 |