pd 98059 has been researched along with Germinoblastoma in 4 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four cell lines and all chronic lymphocytic leukemia cells were killed in 6 hours by vinblastine alone." | 1.36 | Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed. ( Albershardt, TC; Bates, DJ; Eastman, A; Lowrey, CH; Salerni, BL, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salerni, BL | 1 |
| Bates, DJ | 1 |
| Albershardt, TC | 1 |
| Lowrey, CH | 1 |
| Eastman, A | 1 |
| Tome, ME | 1 |
| Jaramillo, MC | 1 |
| Briehl, MM | 1 |
| Liu, S | 1 |
| Li, H | 1 |
| Chen, L | 1 |
| Yang, L | 1 |
| Li, L | 1 |
| Tao, Y | 1 |
| Li, W | 1 |
| Li, Z | 1 |
| Liu, H | 1 |
| Tang, M | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Cao, Y | 1 |
| Kalas, W | 1 |
| Kisielow, P | 1 |
| Strzadala, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vinblastine Versus Oral Hydroxiurea in Newly Diagnosed AML With Hyperleukocytosis: a Phase 2 Clinical Study[NCT05062278] | Phase 2 | 46 participants (Anticipated) | Interventional | 2021-07-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for pd 98059 and Germinoblastoma
| Article | Year |
|---|---|
Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cycloheximide; Cytoprotection; Drug Screening Assays, Antit | 2010 |
Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells.
Topics: Animals; Apoptosis; Dexamethasone; Flavonoids; Glucocorticoids; Humans; Hydrogen Peroxide; Lymphoma; | 2011 |
(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells.
Topics: Antiviral Agents; Catechin; Cell Line, Tumor; Cell Survival; Chromones; DNA, Viral; Enzyme Activatio | 2013 |
Inhibition of MEK induces fas expression and apoptosis in lymphomas overexpressing Ras.
Topics: Animals; Apoptosis; Chromones; Enzyme Inhibitors; fas Receptor; Flavonoids; Gene Expression Regulati | 2002 |