pd 98059 has been researched along with Experimental Mammary Neoplasms in 5 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that BC brain metastases, in a rat syngeneic model developed in our laboratory, have high expression and activity of MMP2." | 1.34 | MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. ( Kim, HT; Lungu, G; Mendes, O; Stoica, G, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Labriola, L | 1 |
| Salatino, M | 1 |
| Proietti, CJ | 1 |
| Pecci, A | 1 |
| Coso, OA | 1 |
| Kornblihtt, AR | 1 |
| Charreau, EH | 1 |
| Elizalde, PV | 1 |
| Mendes, O | 2 |
| Kim, HT | 1 |
| Lungu, G | 2 |
| Stoica, G | 2 |
| Covaleda, L | 1 |
| Martini-Stoica, H | 1 |
| Xing, C | 1 |
| Imagawa, W | 1 |
| Guan, Y | 1 |
| Woo, PL | 1 |
| Rubenstein, NM | 1 |
| Firestone, GL | 1 |
5 other studies available for pd 98059 and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Nucleus; Enzyme Inhibitors; Female; Flavonoids; Genes | 2003 |
MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2.
Topics: Animals; Astrocytes; Brain Neoplasms; Culture Media, Conditioned; Disease Models, Animal; Female; Fl | 2007 |
FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1.
Topics: Animals; Base Sequence; Blotting, Western; Carcinogens; Cell Line, Tumor; Chromones; Cloning, Molecu | 2008 |
Altered MAP kinase (ERK1,2) regulation in primary cultures of mammary tumor cells: elevated basal activity and sustained response to EGF.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Size; Dose-Res | 1999 |
Transforming growth factor-alpha abrogates the glucocorticoid stimulation of tight junction formation and reverses the steroid-induced down-regulation of fascin in rat mammary epithelial tumor cells by a Ras-dependent pathway.
Topics: Actins; Animals; Anti-Inflammatory Agents; Blotting, Western; Calcium-Calmodulin-Dependent Protein K | 2002 |