pd 98059 has been researched along with Endometrial Neoplasms in 12 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These observations were reinforced in endometrial cancer cells by PD98059 treatment." | 1.46 | IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells. ( Ding, Y; Jiang, J; Lu, B; Ma, Y; Xu, T; Zhang, Y, 2017) |
| "However, a direct role for leptin in endometrial cancer has not been demonstrated." | 1.37 | Leptin activates STAT3 and ERK1/2 pathways and induces endometrial cancer cell proliferation. ( Gong, C; Liu, Y; Lv, L; Sheng, H; Wang, D; Xiao, W; Yin, J, 2011) |
| "Human endometrial carcinoma Ishikawa cells were cultured in vitro." | 1.37 | [Effects of PD98059 and LY294002 on subcutaneous xenograft of human endometrial carcinoma in nude mice]. ( Guo, RX; Qiao, YH; Shi, HR; Wang, XY; Zhang, RF, 2011) |
| "Leptin may promote the proliferation of endometrial cancer Ishikawa cells by activating ERK1/2 signaling pathway." | 1.34 | [The role of ERK1/2 in leptin promoting the proliferation of human endometrial cancer cell line Ishikawa]. ( Gong, C; Liu, Y; Sheng, H; Wang, DH; Xiao, W; Yin, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, Y | 1 |
| Lu, H | 1 |
| Yang, X | 1 |
| Song, W | 1 |
| Ma, Y | 1 |
| Jiang, J | 1 |
| Zhang, Y | 1 |
| Ding, Y | 1 |
| Xu, T | 1 |
| Lu, B | 1 |
| Zhang, G | 1 |
| Cheng, Y | 1 |
| Zhang, Q | 1 |
| Li, X | 1 |
| Zhou, J | 1 |
| Wang, J | 1 |
| Wei, L | 1 |
| Chen, HX | 1 |
| Xu, XX | 1 |
| Tan, BZ | 1 |
| Zhang, Z | 1 |
| Zhou, XD | 1 |
| Liu, Y | 2 |
| Lv, L | 1 |
| Xiao, W | 2 |
| Gong, C | 2 |
| Yin, J | 2 |
| Wang, D | 1 |
| Sheng, H | 2 |
| Guo, RX | 1 |
| Zhang, RF | 1 |
| Wang, XY | 1 |
| Shi, HR | 1 |
| Qiao, YH | 1 |
| Leong, H | 1 |
| Riby, JE | 1 |
| Firestone, GL | 1 |
| Bjeldanes, LF | 1 |
| Vivacqua, A | 1 |
| Bonofiglio, D | 1 |
| Recchia, AG | 1 |
| Musti, AM | 1 |
| Picard, D | 1 |
| Andò, S | 1 |
| Maggiolini, M | 1 |
| Wang, DH | 1 |
| Munir, I | 2 |
| Fukunaga, K | 2 |
| Miyazaki, K | 2 |
| Okamura, H | 2 |
| Miyamoto, E | 2 |
| Kanasaki, H | 1 |
| Ohba, T | 1 |
| Lee, H | 1 |
| Jiang, F | 1 |
| Wang, Q | 1 |
| Nicosia, SV | 1 |
| Yang, J | 1 |
| Su, B | 1 |
| Bai, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Serum Autotaxin as a Potential Biomarker in Systemic Lupus Erythematosus Patients and Its Relation to Disease Activity.[NCT06063668] | 94 participants (Anticipated) | Observational | 2023-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 other studies available for pd 98059 and Endometrial Neoplasms
| Article | Year |
|---|---|
BarH-like homeobox 1 induces the progression of cell malignant phenotype in endometrial carcinoma through the regulation of ERK/MEK signaling pathway.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Survival; Endometrial Neoplasms; Extracellular Sign | 2021 |
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cy | 2017 |
ATX‑LPA axis facilitates estrogen‑induced endometrial cancer cell proliferation via MAPK/ERK signaling pathway.
Topics: Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Endometrial Neo | 2018 |
MicroRNA-29b Inhibits Angiogenesis by Targeting VEGFA through the MAPK/ERK and PI3K/Akt Signaling Pathways in Endometrial Carcinoma.
Topics: Androstadienes; Animals; Cell Line, Tumor; Endometrial Neoplasms; Female; Flavonoids; Gene Expressio | 2017 |
Leptin activates STAT3 and ERK1/2 pathways and induces endometrial cancer cell proliferation.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Enzyme Inhibitors; Fema | 2011 |
[Effects of PD98059 and LY294002 on subcutaneous xenograft of human endometrial carcinoma in nude mice].
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relat | 2011 |
Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dep | 2004 |
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.
Topics: Androstadienes; Cell Proliferation; Endometrial Neoplasms; Enzyme Activation; Enzyme Inhibitors; Est | 2006 |
[The role of ERK1/2 in leptin promoting the proliferation of human endometrial cancer cell line Ishikawa].
Topics: Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Endometrial Neoplasms; Femal | 2007 |
Mitogen-activated protein kinase activation and regulation of cyclooxygenase 2 expression by platelet-activating factor and hCG in human endometrial adenocarcinoma cell line HEC-1B.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents, Hormonal; Chorionic Gonadotropin; Cyclic AMP; | 1999 |
Expression of cyclooxygenase 2 by prostaglandin E(2) in human endometrial adenocarcinoma cell line HEC-1B.
Topics: Adenocarcinoma; Cyclooxygenase 2; Dinoprostone; Endometrial Neoplasms; Enzyme Activation; Enzyme Inh | 2000 |
MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells.
Topics: Endometrial Neoplasms; Enzyme Activation; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor | 2000 |