pd 98059 has been researched along with Disease Models, Animal in 127 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation activation and necroptosis involved in CA/CPR-induced CIRI were regulated by the ERK/calpain-2 signaling pathway." | 8.02 | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. ( Chen, MH; Li, N; Tian, XY; Wang, WY; Wu, ZJ; Xie, L; Yang, YG; Zhao, GY; Zou, XS, 2021) |
| "(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against stroke in rats." | 7.80 | Neuroprotection by (-)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress. ( Chen, F; Lin, Y; Liu, G; Yao, C; Zhang, J, 2014) |
| "To study the role of epidermal growth factor (EGF) , epidermal growth factor receptor(EGFR), extracellular signal-regulated kinase 1/2 (p-ERK1/2) in the pathogenesis of endometriosis under estrogen deprivation conditions." | 7.79 | [Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions]. ( Guo, RM; Sheng, W; Wang, YQ; Yin, LR, 2013) |
| "Nifedipine, an L-type calcium channel blocker, protects against the progression of atherosclerosis." | 7.76 | Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice. ( Araki, E; Fukuda, K; Ishii, N; Kawada, T; Kim-Mitsuyama, S; Kinoshita, H; Matsumura, T; Miyamura, N; Motoshima, H; Nakao, S; Nishikawa, T; Senokuchi, T; Takeya, M; Tsutsumi, A, 2010) |
| "Angiotensin II (Ang II), acting via angiotensin type 1 receptors in the brain, activates the sympathetic nervous system in heart failure (HF)." | 7.74 | Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats. ( Felder, RB; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH, 2008) |
| "We investigated if extracellular signal-regulated kinases (ERK) and oxidative stress are involved in the pathogenesis of arterial hypertension induced by chronic leptin administration in the rat." | 7.74 | Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension. ( Bełtowski, J; Jamroz-Wiśniewska, A; Ksiazek, M; Widomska, S; Wójcicka, G, 2008) |
| "The aim of this study was to evaluate in vivo the antiproliferative effect of an inhibitor of isoprenoids metabolism, lovastatin, in an experimental model of propylthiouracil-induced goiter." | 7.73 | HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. ( Bifulco, M; Carella, C; Fiorentino, L; Gazzerro, P; Gerbasio, D; Laezza, C; Matarese, G; Mazziotti, G; Portella, G, 2006) |
| "Inflammation activation and necroptosis involved in CA/CPR-induced CIRI were regulated by the ERK/calpain-2 signaling pathway." | 4.02 | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. ( Chen, MH; Li, N; Tian, XY; Wang, WY; Wu, ZJ; Xie, L; Yang, YG; Zhao, GY; Zou, XS, 2021) |
| "(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against stroke in rats." | 3.80 | Neuroprotection by (-)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress. ( Chen, F; Lin, Y; Liu, G; Yao, C; Zhang, J, 2014) |
| "To study the role of epidermal growth factor (EGF) , epidermal growth factor receptor(EGFR), extracellular signal-regulated kinase 1/2 (p-ERK1/2) in the pathogenesis of endometriosis under estrogen deprivation conditions." | 3.79 | [Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions]. ( Guo, RM; Sheng, W; Wang, YQ; Yin, LR, 2013) |
| "Nifedipine, an L-type calcium channel blocker, protects against the progression of atherosclerosis." | 3.76 | Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice. ( Araki, E; Fukuda, K; Ishii, N; Kawada, T; Kim-Mitsuyama, S; Kinoshita, H; Matsumura, T; Miyamura, N; Motoshima, H; Nakao, S; Nishikawa, T; Senokuchi, T; Takeya, M; Tsutsumi, A, 2010) |
| "Angiotensin II (Ang II), acting via angiotensin type 1 receptors in the brain, activates the sympathetic nervous system in heart failure (HF)." | 3.74 | Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats. ( Felder, RB; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH, 2008) |
| "We investigated if extracellular signal-regulated kinases (ERK) and oxidative stress are involved in the pathogenesis of arterial hypertension induced by chronic leptin administration in the rat." | 3.74 | Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension. ( Bełtowski, J; Jamroz-Wiśniewska, A; Ksiazek, M; Widomska, S; Wójcicka, G, 2008) |
| "Normal eyes and eyes at 15 min, 2 and 4 days after retinal detachment in C57Bl6 mice were examined by immunohistochemistry using anti-phosphorylated (p) ERK1/2, anti-cyclin D1, anti-p27(KIP1), anti-p27(KIP1) phosphorylated at serine 10 (S10-phospho-p27), and anti-proliferating cell nuclear antigen (PCNA) antibodies with or without treatment with a specific ERK inhibitor, PD98059." | 3.73 | Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment. ( Harada, C; Harada, T; Kase, S; Nakayama, KI; Namekata, K; Ohgami, K; Ohno, S; Shiratori, K; Suzuki, Y; Yoshida, K, 2006) |
| "The aim of this study was to evaluate in vivo the antiproliferative effect of an inhibitor of isoprenoids metabolism, lovastatin, in an experimental model of propylthiouracil-induced goiter." | 3.73 | HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. ( Bifulco, M; Carella, C; Fiorentino, L; Gazzerro, P; Gerbasio, D; Laezza, C; Matarese, G; Mazziotti, G; Portella, G, 2006) |
| "Hypertension was induced in Sprague-Dawley rats by infusing angiotensin II (200 ng/kg per min) through osmotic pumps for 12 days." | 3.72 | NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells. ( de Champlain, J; El Midaoui, A; Laplante, MA; Wu, R, 2003) |
| "Experimental colitis has been shown to trigger bladder hyperactivity and hyperalgesia in rats." | 1.72 | Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization. ( Dong, X; Li, L; Lu, Q; Xu, J; Yang, Z; Yi, S; Zhang, H; Zhao, J; Zhu, J, 2022) |
| "Pulpitis was confirmed by hematoxylin-eosin staining." | 1.51 | Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain. ( Jiang, W; Ni, L; Sun, J; Sun, S; Wang, W, 2019) |
| "Icariin pretreatment could ameliorate the decreased striatum DA content and the loss of TH-IR neurons in the SNpc induced by MPTP." | 1.46 | Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways. ( Chen, L; Chen, WF; Chen, XH; Du, ZR; Teng, JJ; Wong, MS; Wu, L; Xu, AL, 2017) |
| "The clinical and experimental postcardiac arrest treatment has not reached therapeutic success." | 1.43 | PD98059 Protects Brain against Cells Death Resulting from ROS/ERK Activation in a Cardiac Arrest Rat Model. ( Chen, MH; Li, N; Nguyen Thi, PA; Xie, L; Zhuo, XJ, 2016) |
| "In an in vitro model of PE-induced cardiac hypertrophy, Selumetinib significantly inhibited the ERK activation and prevented enlargement of cardiomyocytes or reactivation of certain fetal genes." | 1.43 | Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway. ( Cai, H; Chen, L; Chen, Z; Li, C; Li, S; Li, Y; Long, D; Luo, F; Rao, L; Yang, H; You, G; Zhang, Q, 2016) |
| "In search for drugs to treat neuropsychiatric disorders wherein neurotrophic and neurogenic properties are affected, two neurotrophically active small molecules specially crafted following natural product leads based on 2-oxa-spiro[5." | 1.42 | A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action. ( Chakravarty, S; Das, T; Jhelum, P; Kernie, SG; Kootar, S; Kumar, A; Maitra, S; Mehta, G; Pabbaraja, S; Rajan, WD; Reddy, RG; Samanta, A; Samineni, R, 2015) |
| "Dexmedetomidine showed a protective effect on traumatically injured hippocampal cells with a maximum effect at a dosage of 1 μM." | 1.38 | Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury. ( Coburn, M; Eberhardt, G; Fahlenkamp, AV; Loetscher, PD; Rex, S; Rossaint, R; Schoeler, M; Weis, J, 2012) |
| "Post-myocardial infarction ventricular remodeling is associated with the expression of a variety of factors including S100B that can potentially modulate myocyte apoptosis." | 1.36 | S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction. ( Desjardins, JF; Huttunen, HJ; Izhar, S; Leong-Poi, H; Parker, TG; Tsoporis, JN, 2010) |
| "Leptin is an adipose hormone with well characterized roles in regulating food intake and energy balance." | 1.35 | Leptin protects hippocampal CA1 neurons against ischemic injury. ( Chen, J; Zhang, F, 2008) |
| "Furthermore, preconditioning abolished cerebral ischemia-induced JNK3 activation and enhanced ERK1/2 activation, an effect reversed by MK-801." | 1.35 | Preconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk. ( Brann, DW; Han, D; Li, J; Wang, RM; Yang, LC; Zhang, QG, 2009) |
| "Using a "two-hemorrhage" model of subarachnoid hemorrhage (SAH), this study investigated the function of ERK1/2 and vascular wall cell proliferation in pathological development of cerebral vasospasm." | 1.35 | Role of ERK1/2 and vascular cell proliferation in cerebral vasospasm after experimental subarachnoid hemorrhage. ( Chen, D; Chen, JJ; Guan, JH; Liu, YH; Yin, Q, 2009) |
| "Global cerebral ischemia reperfusion model was established by four-vessel occlusion (4-VO) method, and reperfusion was performed 5 minutes following ischemia." | 1.35 | Relationship between transmembrane signal transduction pathway and DNA repair and the mechanism after global cerebral ischemia-reperfusion in rats. ( He, JX; Lv, JR; Wang, N; Wu, G; Xue, RL; Yao, FZ, 2009) |
| "The protective effect of the SAFE pathway is shown in IPostC, with the activation of TNFalpha, its receptor type 2, and STAT-3." | 1.35 | Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway. ( Lacerda, L; Lecour, S; Opie, LH; Somers, S, 2009) |
| "We previously reported that BC brain metastases, in a rat syngeneic model developed in our laboratory, have high expression and activity of MMP2." | 1.34 | MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. ( Kim, HT; Lungu, G; Mendes, O; Stoica, G, 2007) |
| "We examined the air-puff thresholds (mechanical allodynia), scores of pinprick (mechanical hyperalgesia), and face grooming frequency for acetone application (hypersensitivity for cold stimulation) - 3, 3, 6, 9, 12, 15, 20, 25, 30, and 40 days after surgery." | 1.34 | Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats. ( Ahn, DK; Han, SR; Jeon, HJ; Ju, JS; Lee, MK; Lim, EJ; Yang, GY, 2007) |
| "Even though cerebral vasospasm after subarachnoid hemorrhage (SAH) causes cerebral ischemia or infarction, the metabolic alterations in cerebrospinal fluids (CSF) after SAH have not been studied." | 1.31 | Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs. ( Aoki, K; Badr, A; Tibbs, R; Yin, W; Zhang, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 54 (42.52) | 29.6817 |
| 2010's | 62 (48.82) | 24.3611 |
| 2020's | 11 (8.66) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 3 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Zyuz'kov, GN | 2 |
| Miroshnichenko, LA | 2 |
| Polyakova, TY | 1 |
| Zhdanov, VV | 2 |
| Simanina, EV | 2 |
| Stavrova, LA | 2 |
| Churin, AA | 1 |
| Fomina, TI | 1 |
| Zhang, H | 3 |
| Dong, X | 1 |
| Yang, Z | 1 |
| Zhao, J | 1 |
| Lu, Q | 2 |
| Zhu, J | 1 |
| Li, L | 6 |
| Yi, S | 1 |
| Xu, J | 1 |
| Ahmad, SF | 1 |
| Ansari, MA | 1 |
| Nadeem, A | 1 |
| Bakheet, SA | 1 |
| Alasmari, AF | 1 |
| Shahid, M | 1 |
| Al-Mazroua, HA | 1 |
| Alomar, HA | 1 |
| AsSobeai, HM | 1 |
| Alshamrani, AA | 1 |
| Attia, SM | 1 |
| Jalilzad, M | 1 |
| Jafari, A | 1 |
| Babaei, P | 1 |
| Maruta, T | 1 |
| Nemoto, T | 1 |
| Hidaka, K | 1 |
| Koshida, T | 1 |
| Shirasaka, T | 1 |
| Yanagita, T | 1 |
| Takeya, R | 1 |
| Tsuneyoshi, I | 1 |
| Zhang, X | 1 |
| Zhang, R | 1 |
| Chen, J | 4 |
| Wu, J | 1 |
| Zheng, JH | 2 |
| Chen, MH | 4 |
| Fu, ZY | 2 |
| Li, N | 7 |
| Xie, L | 5 |
| Liu, X | 1 |
| Zhang, S | 1 |
| Xu, C | 1 |
| Sun, Y | 1 |
| Sui, S | 1 |
| Zhang, Z | 1 |
| Luan, Y | 1 |
| Lyu, C | 1 |
| Jiang, S | 1 |
| Kong, M | 1 |
| Chen, X | 3 |
| Zhang, L | 2 |
| Wang, WY | 1 |
| Zou, XS | 1 |
| Yang, YG | 1 |
| Wu, ZJ | 1 |
| Tian, XY | 1 |
| Zhao, GY | 1 |
| Li, J | 4 |
| Jia, Z | 1 |
| Zhang, Q | 2 |
| Dai, J | 1 |
| Kong, J | 1 |
| Fan, Z | 1 |
| Li, G | 1 |
| Yoon, SY | 1 |
| Kwon, SG | 1 |
| Kim, YH | 1 |
| Yeo, JH | 1 |
| Ko, HG | 1 |
| Roh, DH | 1 |
| Kaang, BK | 1 |
| Beitz, AJ | 1 |
| Lee, JH | 4 |
| Oh, SB | 1 |
| Cui, J | 1 |
| Cui, C | 1 |
| Cui, Y | 1 |
| Li, R | 1 |
| Sheng, H | 1 |
| Jiang, X | 1 |
| Tian, Y | 1 |
| Wang, K | 1 |
| Gao, J | 1 |
| Lin, W | 1 |
| Huang, W | 1 |
| Chen, S | 3 |
| Lin, M | 1 |
| Huang, Q | 2 |
| Huang, H | 1 |
| Tabata, M | 1 |
| Terayama, R | 1 |
| Maruhama, K | 1 |
| Iida, S | 1 |
| Sugimoto, T | 1 |
| Galán, A | 1 |
| Jmaeff, S | 1 |
| Barcelona, PF | 1 |
| Brahimi, F | 1 |
| Sarunic, MV | 1 |
| Saragovi, HU | 1 |
| Fu, C | 1 |
| Yuan, Y | 1 |
| Wang, R | 2 |
| Yang, J | 1 |
| Guo, Z | 1 |
| Wang, S | 2 |
| Zhang, Y | 2 |
| Liu, Y | 3 |
| Dong, J | 1 |
| Li, Z | 1 |
| Shen, Y | 1 |
| Chen, Y | 1 |
| Zhang, G | 1 |
| Cheng, J | 1 |
| Wang, W | 3 |
| Tang, X | 1 |
| Xiao, Q | 1 |
| Yao, Q | 1 |
| Allen, M | 1 |
| Wang, Y | 1 |
| Gao, L | 1 |
| Qi, Y | 2 |
| Zhang, P | 1 |
| Siles, L | 1 |
| Ninfali, C | 1 |
| Cortés, M | 1 |
| Darling, DS | 1 |
| Postigo, A | 1 |
| Sun, P | 1 |
| Tang, LN | 1 |
| Li, GZ | 1 |
| Xu, ZL | 1 |
| Xu, QH | 1 |
| Wang, M | 1 |
| Sun, S | 1 |
| Sun, J | 1 |
| Jiang, W | 1 |
| Ni, L | 1 |
| Jiang, L | 2 |
| Qiao, Y | 1 |
| Wang, Z | 2 |
| Ma, X | 1 |
| Wang, H | 2 |
| Tan, XF | 1 |
| Tao, R | 1 |
| Qin, T | 1 |
| Tang, CR | 1 |
| Luo, SG | 1 |
| Lin, X | 1 |
| Wang, J | 2 |
| Yang, H | 2 |
| Li, X | 2 |
| Ma, J | 2 |
| Lv, X | 1 |
| Zhao, S | 1 |
| Lang, W | 1 |
| Sharma, R | 1 |
| Wu, X | 1 |
| Rhodes, SD | 1 |
| He, Y | 1 |
| Yuan, J | 1 |
| Yang, X | 2 |
| Kim, ET | 1 |
| Stevenson, DA | 1 |
| Viskochil, D | 1 |
| Xu, M | 1 |
| Yang, FC | 1 |
| Shao, YR | 1 |
| Shen, J | 1 |
| Yuan, Z | 1 |
| He, DK | 1 |
| Wang, YQ | 1 |
| Yin, LR | 1 |
| Guo, RM | 1 |
| Sheng, W | 1 |
| Lee, JM | 1 |
| Kim, JD | 1 |
| Oh, EJ | 1 |
| Oh, SH | 1 |
| Im, GI | 1 |
| Yao, C | 1 |
| Zhang, J | 4 |
| Liu, G | 1 |
| Chen, F | 1 |
| Lin, Y | 1 |
| Feld, M | 1 |
| Krawczyk, MC | 1 |
| Sol Fustiñana, M | 1 |
| Blake, MG | 1 |
| Baratti, CM | 1 |
| Romano, A | 1 |
| Boccia, MM | 1 |
| Hou, Y | 1 |
| Ryu, CH | 1 |
| Jun, JA | 1 |
| Kim, SM | 1 |
| Jeong, CH | 1 |
| Jeun, SS | 1 |
| Martín, P | 1 |
| Mora, I | 1 |
| Cortes, MA | 1 |
| Calleros, L | 1 |
| García-Jerez, A | 1 |
| Ortiz, A | 1 |
| Rodríguez-Puyol, M | 1 |
| Rodríguez-Puyol, D | 1 |
| Olmos, G | 1 |
| Huang, J | 1 |
| Zeng, Z | 1 |
| Luo, J | 1 |
| Liu, P | 1 |
| Liu, B | 1 |
| Pan, X | 1 |
| Zang, L | 1 |
| Zhou, S | 1 |
| Du, ZD | 1 |
| Hu, LT | 1 |
| Zhao, GQ | 1 |
| Li, Y | 2 |
| Ma, ZZ | 1 |
| Huang, P | 1 |
| Zhuang, B | 1 |
| Yan, H | 1 |
| Xiao, Z | 1 |
| Tang, Q | 1 |
| Hu, K | 1 |
| Koeffler, HP | 1 |
| Yin, D | 1 |
| Chakravarty, S | 1 |
| Maitra, S | 1 |
| Reddy, RG | 1 |
| Das, T | 1 |
| Jhelum, P | 1 |
| Kootar, S | 1 |
| Rajan, WD | 1 |
| Samanta, A | 1 |
| Samineni, R | 1 |
| Pabbaraja, S | 1 |
| Kernie, SG | 1 |
| Mehta, G | 1 |
| Kumar, A | 1 |
| Rojewska, E | 1 |
| Popiolek-Barczyk, K | 1 |
| Kolosowska, N | 1 |
| Piotrowska, A | 1 |
| Zychowska, M | 1 |
| Makuch, W | 1 |
| Przewlocka, B | 1 |
| Mika, J | 1 |
| Zhang, YB | 1 |
| Guo, ZD | 1 |
| Li, MY | 1 |
| Fong, P | 1 |
| Zhang, JG | 1 |
| Zhang, CW | 1 |
| Gong, KR | 1 |
| Yang, MF | 1 |
| Niu, JZ | 1 |
| Ji, XM | 1 |
| Lv, GW | 1 |
| Lee, S | 1 |
| Yang, M | 1 |
| Kim, J | 2 |
| Son, Y | 1 |
| Kang, S | 1 |
| Ahn, W | 1 |
| Kim, SH | 1 |
| Kim, JC | 1 |
| Shin, T | 1 |
| Moon, C | 1 |
| Zhuo, X | 1 |
| Shi, FR | 1 |
| Chen, M | 1 |
| Li, E | 1 |
| Deng, H | 1 |
| Wang, B | 1 |
| Fu, W | 1 |
| You, Y | 1 |
| Tian, S | 1 |
| Reichl, S | 1 |
| Segelcke, D | 1 |
| Keller, V | 1 |
| Jonas, R | 1 |
| Boecker, A | 1 |
| Wenk, M | 1 |
| Evers, D | 1 |
| Zahn, PK | 1 |
| Pogatzki-Zahn, EM | 1 |
| Nguyen Thi, PA | 1 |
| Zhuo, XJ | 1 |
| Cui, R | 1 |
| Teng, Y | 1 |
| Li, K | 1 |
| Li, C | 1 |
| Chen, Z | 1 |
| Luo, F | 1 |
| Chen, L | 2 |
| Cai, H | 1 |
| You, G | 1 |
| Long, D | 1 |
| Li, S | 3 |
| Rao, L | 1 |
| Udut, EV | 1 |
| Khrichkova, TY | 1 |
| Sherstoboev, EY | 1 |
| Agafonov, VI | 1 |
| Chaikovskii, AV | 1 |
| Minakova, MY | 1 |
| Dygai, AM | 1 |
| Zhang, LM | 1 |
| Zhang, DX | 1 |
| Zhao, XC | 1 |
| Sun, WB | 1 |
| Jiang, XJ | 1 |
| Bai, Q | 1 |
| Lyu, Z | 1 |
| Pan, Z | 1 |
| Lou, J | 1 |
| Dong, T | 1 |
| Chen, WF | 1 |
| Wu, L | 2 |
| Du, ZR | 1 |
| Xu, AL | 1 |
| Chen, XH | 1 |
| Teng, JJ | 1 |
| Wong, MS | 1 |
| Wei, SG | 1 |
| Yu, Y | 1 |
| Zhang, ZH | 1 |
| Weiss, RM | 1 |
| Felder, RB | 1 |
| Jin, YC | 1 |
| Kim, KJ | 1 |
| Kim, YM | 2 |
| Ha, YM | 1 |
| Kim, HJ | 2 |
| Yun, UJ | 1 |
| Bae, KH | 1 |
| Kim, YS | 2 |
| Kang, SS | 1 |
| Seo, HG | 1 |
| Chang, KC | 2 |
| Zhang, F | 2 |
| Zhang, M | 1 |
| Hallows, JL | 1 |
| Wang, X | 1 |
| Bu, B | 1 |
| Vincent, I | 1 |
| Jing, L | 1 |
| Li, WM | 3 |
| Zhou, LJ | 1 |
| Kou, JJ | 1 |
| Song, J | 1 |
| Mühlen, S | 1 |
| Behren, A | 1 |
| Iftner, T | 1 |
| Plinkert, PK | 1 |
| Simon, C | 1 |
| Flanigan, TL | 1 |
| Owen, CR | 1 |
| Gayer, C | 1 |
| Basson, MD | 1 |
| Cazarolli, LH | 1 |
| Folador, P | 1 |
| Moresco, HH | 1 |
| Brighente, IM | 1 |
| Pizzolatti, MG | 1 |
| Silva, FR | 1 |
| Franke, H | 1 |
| Sauer, C | 1 |
| Rudolph, C | 1 |
| Krügel, U | 1 |
| Hengstler, JG | 1 |
| Illes, P | 1 |
| Codeluppi, S | 1 |
| Svensson, CI | 1 |
| Hefferan, MP | 1 |
| Valencia, F | 1 |
| Silldorff, MD | 1 |
| Oshiro, M | 1 |
| Marsala, M | 1 |
| Pasquale, EB | 1 |
| Das, A | 1 |
| Salloum, FN | 1 |
| Xi, L | 1 |
| Rao, YJ | 1 |
| Kukreja, RC | 1 |
| Matsumoto, T | 2 |
| Ishida, K | 1 |
| Nakayama, N | 1 |
| Kobayashi, T | 2 |
| Kamata, K | 2 |
| Javadov, S | 1 |
| Rajapurohitam, V | 1 |
| Kilić, A | 1 |
| Zeidan, A | 1 |
| Choi, A | 1 |
| Karmazyn, M | 1 |
| Zhang, QG | 1 |
| Wang, RM | 1 |
| Han, D | 1 |
| Yang, LC | 1 |
| Brann, DW | 1 |
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127 other studies available for pd 98059 and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Role of MAPK ERK1/2 and p38 in the Regulation of Secretory Functions of Different Populations of Neuroglia in Ethanol-Induced Neurodegeneration.
Topics: Animals; Astrocytes; Culture Media, Conditioned; Disease Models, Animal; Ethanol; Flavonoids; Gene E | 2021 |
Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization.
Topics: Animals; Benzylamines; Colitis; Cyclams; Disease Models, Animal; Extracellular Signal-Regulated MAP | 2022 |
MAP kinase inhibitor PD98059 regulates Th1, Th9, Th17, and natural T regulatory cells in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; | 2023 |
Neuregulin1β improves both spatial and associative learning and memory in Alzheimer model of rats possibly through signaling pathways other than Erk1/2.
Topics: Alzheimer Disease; Animals; Association Learning; Disease Models, Animal; Flavonoids; Male; MAP Kina | 2019 |
Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Extracellular Signal-Regulated M | 2019 |
Neuroprotective effects of DAAO are mediated via the ERK1/2 signaling pathway in a glaucomatous animal model.
Topics: Animals; Blotting, Western; D-Amino-Acid Oxidase; Disease Models, Animal; Ependymoglial Cells; Flavo | 2020 |
PD98059 Protects Cerebral Cortex Mitochondrial Structure and Function at 48 h Post-Resuscitation in a Rat Model of Cardiac Arrest.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Flavonoids; Hear | 2020 |
The Protective of Baicalin on Myocardial Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Cell Survival; Disease Models, Animal; Flavonoids; Male; MAP Kinase Signaling Sy | 2020 |
Vitamin D protects against necrotising enterocolitis in newborn mice by activating the ERK signalling pathway.
Topics: Animals; Animals, Newborn; Cell Line; Cell Proliferation; Cell Survival; Disease Models, Animal; Ent | 2020 |
Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest.
Topics: Animals; Brain Ischemia; Calpain; Dipeptides; Disease Models, Animal; Extracellular Signal-Regulated | 2021 |
Inhibition of ERK1/2 phosphorylation attenuates spinal cord injury induced astrocyte activation and inflammation through negatively regulating aquaporin-4 in rats.
Topics: Animals; Aquaporin 4; Astrocytes; Cell Proliferation; Disease Models, Animal; Female; Flavonoids; In | 2021 |
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agon | 2017 |
Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage.
Topics: Animals; Axons; Bone Marrow Cells; Cells, Cultured; Cerebral Hemorrhage; Chromones; Disease Models, | 2017 |
The Role of 5-HTR6 in Mossy Fiber Sprouting: Activating Fyn and p-ERK1/2 in Pilocarpine-Induced Chronic Epileptic Rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Flavonoids; GAP-43 Protein; Male; Mitogen-Activated Prote | 2017 |
Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury.
Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hyperalgesi | 2018 |
In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.
Topics: Animals; Cell Death; Disease Models, Animal; Ependymoglial Cells; Extracellular Signal-Regulated MAP | 2017 |
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pres | 2018 |
High Uric Acid Inhibits Cardiomyocyte Viability Through the ERK/P38 Pathway via Oxidative Stress.
Topics: Acetylcysteine; Animals; Cell Line; Cell Survival; Disease Models, Animal; Extracellular Signal-Regu | 2018 |
Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway.
Topics: Adrenocorticotropic Hormone; Animals; Biomechanical Phenomena; Cell Proliferation; Disease Models, A | 2018 |
ZEB1 protects skeletal muscle from damage and is required for its regeneration.
Topics: Animals; Chemokine CCL2; Chromones; Disease Models, Animal; Flavonoids; Gene Expression Regulation; | 2019 |
Effects of MiR-21 on the proliferation and migration of vascular smooth muscle cells in rats with atherosclerosis via the Akt/ERK signaling pathway.
Topics: Animals; Atherosclerosis; Cell Movement; Cell Proliferation; Cells, Cultured; Diet, High-Fat; Diseas | 2019 |
Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain.
Topics: Animals; Dental Pulp Cavity; Disease Models, Animal; Flavonoids; Gene Expression Regulation; Inflamm | 2019 |
Inhibition of microRNA-103 attenuates inflammation and endoplasmic reticulum stress in atherosclerosis through disrupting the PTEN-mediated MAPK signaling.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Endoplasmic Re | 2020 |
PD98059 protects the brain against mitochondrial-mediated apoptosis and autophagy in a cardiac arrest rat model.
Topics: Animals; Apoptosis; Autophagy; Brain; Cardiopulmonary Resuscitation; Cerebral Cortex; Disease Models | 2019 |
Silenced miR-21 inhibits renal interstitial fibrosis via targeting ERK1/2 signaling pathway in mice.
Topics: Actins; Animals; Cell Line; Disease Models, Animal; Fibrosis; Flavonoids; Humans; Kidney Diseases; M | 2019 |
Blockade of the intermediate-conductance Ca(2+)-activated K+ channel inhibits the angiogenesis induced by epidermal growth factor in the treatment of corneal alkali burn.
Topics: Animals; Blotting, Western; Burns, Chemical; Cell Movement; Cell Proliferation; Cornea; Corneal Neov | 2013 |
Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.
Topics: Animals; Cell Lineage; Cells, Cultured; Disease Models, Animal; Flavonoids; Humans; Mice; Mice, Tran | 2013 |
[Effects of phosphorylated mitogen-activated protein kinases on phosgene inhalation-induced lung injury in rats and its relationship with matrix metalloproteinase].
Topics: Animals; Burns, Inhalation; Cytokines; Disease Models, Animal; Flavonoids; Imidazoles; Male; MAP Kin | 2013 |
[Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions].
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endometriosis; Endometrium; Ep | 2013 |
PD98059-impregnated functional PLGA scaffold for direct tissue engineering promotes chondrogenesis and prevents hypertrophy from mesenchymal stem cells.
Topics: Adult; Animals; Chondrogenesis; Collagen; Disease Models, Animal; Flavonoids; Humans; Hypertrophy; I | 2014 |
Neuroprotection by (-)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Caspase 12; Catechin; Cyclic AMP Response Element-Binding Protein; Disease Model | 2014 |
Decrease of ERK/MAPK overactivation in prefrontal cortex reverses early memory deficit in a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Electrophore | 2014 |
IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
Topics: Animals; Bone Marrow Cells; Brain; Cells, Cultured; Chromones; Disease Models, Animal; Extracellular | 2014 |
Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cells, Cultured; Cyclic GMP-Dependent Protein Kinase Type I | 2014 |
Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Topics: Animals; Animals, Newborn; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Ac | 2015 |
Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells.
Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Diseas | 2015 |
Hepatitis B Virus X Protein (HBx) Is Responsible for Resistance to Targeted Therapies in Hepatocellular Carcinoma: Ex Vivo Culture Evidence.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bortezomib; Carcinoma, Hepatocellular; Cell Line, Tumor; | 2015 |
A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action.
Topics: Animals; Azepines; Benzamides; Brain-Derived Neurotrophic Factor; Cell Line; Disease Models, Animal; | 2015 |
PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy.
Topics: Analgesics, Opioid; Animals; Cytokines; Disease Models, Animal; Drug Synergism; Extracellular Signal | 2015 |
Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amines; Animals; Behavior, Animal; Cell Membrane; Cyc | 2015 |
Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Butadienes; Cells, Cultured; Disease Models, Animal; Enz | 2016 |
The benefits of respective and combined use of green tea polyphenols and ERK inhibitor on the survival and neurologic outcomes in cardiac arrest rats induced by ventricular fibrillation.
Topics: Animals; Brain Injuries; Cardiopulmonary Resuscitation; Disease Models, Animal; Female; Flavonoids; | 2016 |
Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats.
Topics: Animals; Antidepressive Agents; Chromones; Corticosterone; Depression; Disease Models, Animal; Enzym | 2016 |
Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats.
Topics: Action Potentials; Animals; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Excitatory Ami | 2016 |
PD98059 Protects Brain against Cells Death Resulting from ROS/ERK Activation in a Cardiac Arrest Rat Model.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; DNA Fragmentation; Down-Regulation; Flavonoids; H | 2016 |
Chitosan Promoted the Corneal Epithelial Wound Healing via Activation of ERK Pathway.
Topics: Animals; Blotting, Western; Cell Migration Assays; Cell Movement; Cell Proliferation; Cells, Culture | 2017 |
Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Aorta; Apoptosis; Benzimidazoles; Cardiomegaly | 2016 |
Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.
Topics: Anemia; Animals; Bone Marrow Cells; Chromones; Disease Models, Animal; Erythropoiesis; Erythropoieti | 2016 |
Sevoflurane pre-conditioning increases phosphorylation of Erk1/2 and HO-1 expression via inhibition of mPTP in primary rat cortical neurons exposed to OGD/R.
Topics: Animals; Apoptosis; Atractyloside; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cyclosporine; Dis | 2017 |
Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke.
Topics: Angiogenesis Inducing Agents; Animals; Brain; Catechin; Disease Models, Animal; Flavonoids; Infarcti | 2017 |
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromones; Corpus Striatum; Disease Models, A | 2017 |
Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats.
Topics: Acute Disease; Analysis of Variance; Angiotensin II; Animals; Chronic Disease; Disease Models, Anima | 2008 |
Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo.
Topics: Animals; Apoptosis; Biphenyl Compounds; Caspase 3; Disease Models, Animal; Flavonoids; Heart; Lignan | 2008 |
Leptin protects hippocampal CA1 neurons against ischemic injury.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Chromones; CREB-Binding Protein; Disease | 2008 |
Mitogen-activated protein kinase activity may not be necessary for the neuropathology of Niemann-Pick type C mice.
Topics: Animals; Blotting, Western; Brain; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Immunohist | 2008 |
Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Bi | 2008 |
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Topics: Animals; Anthracenes; Binding Sites; Carcinoma; Cell Line; Cell Line, Tumor; Cottontail rabbit papil | 2009 |
Supraphysiologic extracellular pressure inhibits intestinal epithelial wound healing independently of luminal nutrient flow.
Topics: Acetic Acid; Anastomosis, Roux-en-Y; Animals; Blotting, Western; Cell Movement; Dimethyl Sulfoxide; | 2008 |
Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake.
Topics: Alloxan; Androstadienes; Animals; Biological Transport; Blood Glucose; Carbon Radioisotopes; Colchic | 2009 |
P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo.
Topics: Adenosine Diphosphate; Androstadienes; Animals; Apoptosis; Astrocytes; Brain Injuries; Disease Model | 2009 |
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.
Topics: Analysis of Variance; Animals; Astrocytes; Cells, Cultured; Chromones; Disease Models, Animal; Enzym | 2009 |
ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.
Topics: Animals; bcl-2-Associated X Protein; Cardiovascular Agents; Cyclic GMP-Dependent Protein Kinases; Cy | 2009 |
Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Butadienes; Diabetes Mellitus, Type 2; Diabetic Angio | 2009 |
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cardiomegaly; | 2009 |
Preconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk.
Topics: Analysis of Variance; Animals; Brain Ischemia; CREB-Binding Protein; Disease Models, Animal; Dizocil | 2009 |
Role of ERK1/2 and vascular cell proliferation in cerebral vasospasm after experimental subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Cell Proliferation; Disease Models, Animal; Enzyme Activation; Enzyme Inhib | 2009 |
Relationship between transmembrane signal transduction pathway and DNA repair and the mechanism after global cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lya | 2009 |
Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Caspase 3; Creatinine; Cyclic G | 2009 |
Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Down-Regulation; Extracellular | 2009 |
Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway.
Topics: Androstadienes; Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavono | 2009 |
Increased phosphorylation of extracellular signal-regulated kinase in the medial prefrontal cortex of the single-prolonged stress rats.
Topics: Animals; Anxiety; Behavior, Animal; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Extr | 2010 |
S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction.
Topics: Animals; Apoptosis; Butadienes; Caspase 3; Cell Line; Cytochromes c; Cytosol; Disease Models, Animal | 2010 |
Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Antioxida | 2010 |
[Myocardial inflammation and injury induced by coronary microembolization in rats: role of ERK1/2 signaling pathway].
Topics: Animals; Coronary Occlusion; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fla | 2010 |
Cyclic stretch induces proliferation and TGF-beta1-mediated apoptosis via p38 and ERK in ureteric bud cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Cell Proliferation; Disease Models, Animal; Enzyme Inhibi | 2010 |
Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.
Topics: Amlodipine; Animals; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP-Bin | 2010 |
Calcitonin gene-related peptide as a regulator of neuronal CaMKII-CREB, microglial p38-NFκB and astroglial ERK-Stat1/3 cascades mediating the development of tolerance to morphine-induced analgesia.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Calcitonin Recep | 2010 |
Role of extracellular signal-regulated kinase in regulating expression of interleukin 13 in lymphocytes from an asthmatic rat model.
Topics: Animals; Asthma; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Extrace | 2010 |
The role of ERK1/2 signaling pathway in coronary microembolization-induced rat myocardial inflammation and injury.
Topics: Animals; Blotting, Far-Western; Calcium-Calmodulin-Dependent Protein Kinases; Coronary Occlusion; Di | 2010 |
Parathyroid hormone-related peptide regulates matrix metalloproteinase-13 gene expression in bone metastatic breast cancer cells.
Topics: Animals; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; D | 2010 |
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, | 2012 |
Extracellular signal-regulated kinase (ERK) inhibition decreases arginase activity and improves corpora cavernosal relaxation in streptozotocin (STZ)-induced diabetic mice.
Topics: Analysis of Variance; Animals; Arginase; Diabetes Mellitus, Experimental; Disease Models, Animal; En | 2011 |
Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.
Topics: Acetic Acid; Androstadienes; Animals; Anthracenes; Benzoquinones; Disease Models, Animal; Flavonoids | 2012 |
Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Diabetes Mellitus, Type 2; | 2012 |
Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Injuries; Cell Count; Dexmedetomidine; Diseas | 2012 |
A key role of toll-like receptor 3 in tissue factor activation through extracellular signal regulated kinase 1/2 pathway in a murine hypoxia model.
Topics: Animals; Antibodies, Neutralizing; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinase | 2012 |
Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury.
Topics: Animals; Animals, Newborn; Arachidonate 5-Lipoxygenase; Astrocytes; Brain Edema; Brain Ischemia; Dis | 2012 |
Intrathecal endothelin-1 has antinociceptive effects in rat model of postoperative pain.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Endothelin-1; Extracellular Signal-Re | 2012 |
Lumican regulates ventilation-induced epithelial-mesenchymal transition through extracelluar signal-regulated kinase pathway.
Topics: Animals; Cadherins; Chemokine CXCL2; Chondroitin Sulfate Proteoglycans; Disease Models, Animal; Epit | 2013 |
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electromyography; Enzyme Inhibitors; Excitato | 2012 |
Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs.
Topics: Analysis of Variance; Animals; Caspase Inhibitors; Cerebral Hemorrhage; Disease Models, Animal; Dogs | 2002 |
The progression in the mouse skin carcinogenesis model correlates with ERK1/2 signaling.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Flavonoids; Genes, ras; Immunohist | 2002 |
Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation.
Topics: Age Factors; Aging; Animals; Aorta; Apoptosis; Arteriosclerosis; Catheterization; Cell Division; Cel | 2003 |
Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis.
Topics: Animals; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Growth | 2003 |
NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Disease Model | 2003 |
Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.
Topics: Animals; Cell Division; Cell Movement; Chemotaxis; Disease Models, Animal; Down-Regulation; Flavonoi | 2004 |
Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.
Topics: Adenoviridae; Angiopoietin-2; Animals; Blotting, Northern; Blotting, Western; Butadienes; Carbazoles | 2004 |
A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance.
Topics: Animals; Apoptosis; Ascites; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Disease Models | 2005 |
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
Topics: alpha-Crystallin B Chain; Animals; Becaplermin; Blotting, Western; Disease Models, Animal; Enzyme In | 2005 |
Evidence for a role of mitogen-activated protein kinase 3/mitogen-activated protein kinase in the development of testicular ischemia-reperfusion injury.
Topics: Animals; Disease Models, Animal; Edema; Enzyme Inhibitors; Flavonoids; Male; Mitogen-Activated Prote | 2005 |
Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; C | 2006 |
Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.
Topics: Administration, Oral; Animals; Cell Line, Tumor; Centella; Disease Models, Animal; Ethanol; Flavonoi | 2005 |
Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair.
Topics: Acetic Acid; Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; Dose-Response Relationsh | 2005 |
The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Carrageenan; Disea | 2006 |
The kv4.2 potassium channel subunit is required for pain plasticity.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Blotting, West | 2006 |
HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.
Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Transf | 2006 |
Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals | 2007 |
ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Butadienes; Disease Models, Animal; Endoth | 2007 |
Green tea polyphenols reduce autoimmune symptoms in a murine model for human Sjogren's syndrome and protect human salivary acinar cells from TNF-alpha-induced cytotoxicity.
Topics: Animals; Autoimmunity; Catechin; Cell Line; Cell Survival; Disease Models, Animal; Flavonoids; Human | 2007 |
Delay of photoreceptor degeneration in tubby mouse by sulforaphane.
Topics: Adaptor Proteins, Signal Transducing; Age Factors; Animals; Animals, Newborn; Disease Models, Animal | 2007 |
MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2.
Topics: Animals; Astrocytes; Brain Neoplasms; Culture Media, Conditioned; Disease Models, Animal; Female; Fl | 2007 |
Extracellular signal-regulated kinase pathways may mediate the protective effect of electrical stimulation of the paraventricular nucleus against ischaemia-reperfusion injury of the gastric mucosa.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Celiac Artery; Cell Proliferation; Disease Models, A | 2007 |
Preconditioning with hyperbaric oxygen attenuates brain edema after experimental intracerebral hemorrhage.
Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Drug Administration Schedu | 2007 |
Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats.
Topics: Animals; Behavior, Animal; Body Weight; Constriction; Disease Models, Animal; Dose-Response Relation | 2007 |
Patterns of kinase activation induced by injury in the murine femoral artery.
Topics: Animals; Anthracenes; Calcium Signaling; Cell Division; Disease Models, Animal; Femoral Artery; Flav | 2007 |
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.
Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal; | 2008 |
Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.
Topics: Androstadienes; Animals; Argon; Atractyloside; Cardiotonic Agents; Disease Models, Animal; Enzyme Ac | 2007 |
Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling.
Topics: Adipocytes; Animals; Apoptosis; Caspase 3; Caspase 9; Catecholamines; Cell Line; Cell Survival; CREB | 2007 |
Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension.
Topics: Animals; Aorta; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Drug Administration Schedul | 2008 |
Role of extracellular signal-regulated kinase signal transduction pathway in anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Blotting, Western; Control Groups | 2008 |
Calcium-sensing receptors induce apoptosis in cultured neonatal rat ventricular cardiomyocytes during simulated ischemia/reperfusion.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Calcium; Cells, Cultured; Disea | 2008 |
CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis.
Topics: Adult; Aged; Animals; Animals, Newborn; Biomarkers; Blotting, Northern; Cells, Cultured; Colforsin; | 2000 |
Effects of mitogen-activated protein kinase inhibitors on cerebral vasospasm in a double-hemorrhage model in dogs.
Topics: Animals; Butadienes; Cerebral Angiography; Cerebral Arteries; Disease Models, Animal; Dogs; Flavonoi | 2000 |
Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease.
Topics: Animals; Cell Line; Cell Survival; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fla | 2001 |
MAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction.
Topics: Animals; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; | 2002 |