pd 98059 has been researched along with Diabetic Nephropathies in 8 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Taurine is a well documented antioxidant agent." | 5.35 | Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. ( Chuang, LY; Guh, JY; Hsu, MS; Huang, JS; Yang, YL, 2008) |
| "Taurine is a well documented antioxidant agent." | 1.35 | Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. ( Chuang, LY; Guh, JY; Hsu, MS; Huang, JS; Yang, YL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, JJ | 1 |
| Hyun, YY | 1 |
| Jee, YH | 1 |
| Lee, MJ | 1 |
| Han, KH | 1 |
| Kang, YS | 1 |
| Han, SY | 1 |
| Cha, DR | 1 |
| Zhou, H | 1 |
| Yao, C | 1 |
| Bian, A | 1 |
| Qian, J | 1 |
| Zhao, X | 1 |
| Zhao, Y | 1 |
| Wang, W | 1 |
| Xing, C | 1 |
| Huang, JS | 1 |
| Chuang, LY | 1 |
| Guh, JY | 1 |
| Yang, YL | 1 |
| Hsu, MS | 1 |
| Liu, W | 1 |
| Lan, T | 1 |
| Xie, X | 1 |
| Huang, K | 1 |
| Peng, J | 1 |
| Huang, J | 1 |
| Shen, X | 1 |
| Liu, P | 1 |
| Huang, H | 2 |
| Bai, Y | 1 |
| Wang, L | 1 |
| Li, Y | 1 |
| Liu, S | 1 |
| Li, J | 1 |
| Wang, H | 1 |
| Lin, CL | 1 |
| Wang, FS | 1 |
| Kuo, YR | 1 |
| Huang, YT | 1 |
| Huang, HC | 1 |
| Sun, YC | 1 |
| Kuo, YH | 1 |
| Foutz, RM | 1 |
| Grimm, PR | 1 |
| Sansom, SC | 1 |
| Haneda, M | 1 |
| Araki, S | 1 |
| Togawa, M | 1 |
| Sugimoto, T | 1 |
| Isono, M | 1 |
| Kikkawa, R | 1 |
8 other studies available for pd 98059 and Diabetic Nephropathies
| Article | Year |
|---|---|
Plasma concentration of soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in type 2 diabetic patients, and sICAM-1 synthesis is associated with leptin-induced activation of the mitogen-activated protein kinase (MAPK) pathway.
Topics: Albuminuria; Blood Glucose; Body Mass Index; Cells, Cultured; Creatinine; Diabetes Mellitus, Type 2; | 2013 |
The Ras GTPase-activating-like protein IQGAP1 is downregulated in human diabetic nephropathy and associated with ERK1/2 pathway activation.
Topics: Biopsy; Cells, Cultured; Diabetic Nephropathies; Down-Regulation; Enzyme Activation; Flavonoids; Glu | 2014 |
Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells.
Topics: Animals; Antioxidants; Cell Cycle; Cell Proliferation; Collagen Type IV; Cyclin-Dependent Kinase Inh | 2008 |
S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.
Topics: Animals; Diabetic Nephropathies; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; F | 2012 |
High ambient glucose levels modulates the production of MMP-9 and alpha5(IV) collagen by cultured podocytes.
Topics: Animals; Base Sequence; Cells, Cultured; Collagen Type IV; Diabetic Nephropathies; Flavonoids; Gluco | 2006 |
Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries.
Topics: Animals; Cytosol; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Activation; Extrac | 2006 |
Insulin increases the activity of mesangial BK channels through MAPK signaling.
Topics: Animals; Butadienes; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dietary Fat | 2008 |
Activation of mitogen-activated protein kinase cascade in diabetic glomeruli and mesangial cells cultured under high glucose conditions.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytosol; Diabetic Nephropath | 1997 |