pd 98059 has been researched along with Diabetes Mellitus, Type 2 in 10 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, JJ | 1 |
| Hyun, YY | 1 |
| Jee, YH | 1 |
| Lee, MJ | 1 |
| Han, KH | 1 |
| Kang, YS | 1 |
| Han, SY | 1 |
| Cha, DR | 1 |
| Matsumoto, T | 2 |
| Ishida, K | 1 |
| Nakayama, N | 1 |
| Kobayashi, T | 2 |
| Kamata, K | 2 |
| Su, XL | 1 |
| Wang, Y | 1 |
| Zhang, W | 1 |
| Zhao, LM | 1 |
| Li, GR | 1 |
| Deng, XL | 1 |
| Buonomo, R | 1 |
| Giacco, F | 1 |
| Vasaturo, A | 1 |
| Caserta, S | 1 |
| Guido, S | 1 |
| Pagliara, V | 1 |
| Garbi, C | 1 |
| Mansueto, G | 1 |
| Cassese, A | 1 |
| Perruolo, G | 1 |
| Oriente, F | 1 |
| Miele, C | 1 |
| Beguinot, F | 1 |
| Formisano, P | 1 |
| Taguchi, K | 1 |
| Tokuda, H | 1 |
| Kato, K | 1 |
| Kasahara, S | 1 |
| Matsushima-Nishiwaki, R | 1 |
| Mizuno, T | 1 |
| Sakakibara, S | 1 |
| Kozawa, O | 1 |
| Ramos-Álvarez, I | 1 |
| Martín-Duce, A | 1 |
| Moreno-Villegas, Z | 1 |
| Sanz, R | 1 |
| Aparicio, C | 1 |
| Portal-Núñez, S | 1 |
| Mantey, SA | 1 |
| Jensen, RT | 1 |
| González, N | 1 |
| Li, L | 1 |
| Sawamura, T | 1 |
| Renier, G | 1 |
| Foutz, RM | 1 |
| Grimm, PR | 1 |
| Sansom, SC | 1 |
| Collins, AR | 1 |
| Meehan, WP | 1 |
| Kintscher, U | 1 |
| Jackson, S | 1 |
| Wakino, S | 1 |
| Noh, G | 1 |
| Palinski, W | 1 |
| Hsueh, WA | 1 |
| Law, RE | 1 |
10 other studies available for pd 98059 and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Plasma concentration of soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in type 2 diabetic patients, and sICAM-1 synthesis is associated with leptin-induced activation of the mitogen-activated protein kinase (MAPK) pathway.
Topics: Albuminuria; Blood Glucose; Body Mass Index; Cells, Cultured; Creatinine; Diabetes Mellitus, Type 2; | 2013 |
Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Butadienes; Diabetes Mellitus, Type 2; Diabetic Angio | 2009 |
Insulin-mediated upregulation of K(Ca)3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cell Proliferation; Cel | 2011 |
PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Adhesion; Cell Movement; Cells, Cultured; Diabetes Mell | 2012 |
Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Diabetes Mellitus, Type 2; | 2012 |
Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Case-Control Studies; CD40 Ligand; Diabetes Mellitus, | 2012 |
Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.
Topics: Adult; Aged; Androstadienes; Animals; Biological Transport; Cells, Cultured; Diabetes Mellitus, Type | 2013 |
Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.
Topics: Acetylcysteine; Adult; Aged; Anti-Infective Agents; Antioxidants; Arteriosclerosis; Cells, Cultured; | 2004 |
Insulin increases the activity of mesangial BK channels through MAPK signaling.
Topics: Animals; Butadienes; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dietary Fat | 2008 |
Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta; Arteriosclerosis; Blood Glu | 2001 |