pd 98059 has been researched along with Colorectal Neoplasms in 15 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paclitaxel, one of key drugs to treat a wide range of malignancies, exhibits relative low sensitivity for colorectal cancer." | 7.77 | Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer. ( Iwasaki, H; Katano, M; Kumagai, M; Mibu, R; Nakano, K; Onishi, H; Suzuki, H; Wakabayashi, R; Xu, R; Yamasaki, A, 2011) |
| "In this study, we identified a new mechanism for the anti-proliferation of HCT15 colorectal cancer cells by troglitazone (TRO)." | 7.71 | Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. ( Ahn, Y; Choi, KY; Kim, HI; Kim, JA; Oh, JW; Oh, SY; Park, KS, 2002) |
| "In HT-29 colorectal cancer cells, the ERK activities were increased by zinc, which was accompanied by the induction of p21(Cip/WAF1) and cyclin D1." | 5.31 | Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells. ( Choi, KY; Kim, JA; Oh, SY; Park, KS, 2002) |
| " In this study, we chose human colorectal adenocarcinoma cell line HT-29 as the experimental model, and investigated the differential biological effects between 250 mGy single dose LDIR and 250 mGy intermittent LDIR pretreatments in high dose irradiation (HDIR) radiotherapy and 5-fluorouracil (5-FU) based chemotherapy." | 3.85 | Intermittent low dose irradiation enhances the effectiveness of radio- and chemo-therapy for human colorectal adenocarcinoma cell line HT-29. ( Li, Y; Wang, Y; Yang, L; Yin, D, 2017) |
| "Paclitaxel, one of key drugs to treat a wide range of malignancies, exhibits relative low sensitivity for colorectal cancer." | 3.77 | Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer. ( Iwasaki, H; Katano, M; Kumagai, M; Mibu, R; Nakano, K; Onishi, H; Suzuki, H; Wakabayashi, R; Xu, R; Yamasaki, A, 2011) |
| "In this study, we identified a new mechanism for the anti-proliferation of HCT15 colorectal cancer cells by troglitazone (TRO)." | 3.71 | Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. ( Ahn, Y; Choi, KY; Kim, HI; Kim, JA; Oh, JW; Oh, SY; Park, KS, 2002) |
| "Cachexia affects the majority of cancer patients, with currently no effective treatments." | 1.43 | Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs. ( Barreto, R; Bonetto, A; Gao, H; Liu, Y; Waning, DL; Zimmers, TA, 2016) |
| "Recent evidence suggests that human colorectal cancers are likewise maintained by a minority population of so-called cancer stem cells." | 1.35 | Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells. ( Kirkland, SC; Ying, H, 2008) |
| "The role of the mTOR signal pathway in colorectal cancer (CRC) pathogenesis remains unclear, and the combination effect of PD98059 (an inhibitor for MEK) and rapamycin (an inhibitor for mTOR) on CRC is still unknown." | 1.35 | Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer. ( Fang, JY; Sun, DF; Tian, XQ; Xiong, H; Zhang, YJ; Zhao, SL, 2009) |
| "Three human colorectal cancer cell lines SW480, HCT116 and HT29 were treated with RPM 10 nmol/L, PD98059 (10 micromol/L, 20 micromol/L, 40 micromol/L, 50 micromol/L), or RPM plus PD98059, respectively, and the sensitivity was analyzed by MTT assay." | 1.34 | [Synergistic effect of rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells]. ( Fang, JY; Shen, GF; Sun, DF; Zhang, YJ; Zhao, SL; Zheng, Q; Zhu, HY, 2007) |
| "In HT-29 colorectal cancer cells, the ERK activities were increased by zinc, which was accompanied by the induction of p21(Cip/WAF1) and cyclin D1." | 1.31 | Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells. ( Choi, KY; Kim, JA; Oh, SY; Park, KS, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Li, Y | 1 |
| Yang, L | 2 |
| Yin, D | 1 |
| Tian, XQ | 2 |
| Guo, FF | 1 |
| Sun, DF | 3 |
| Wang, YC | 1 |
| Chen, SL | 1 |
| Hong, J | 1 |
| Fang, JY | 3 |
| Xu, R | 2 |
| Yin, J | 1 |
| Zhang, Y | 1 |
| Zhang, S | 1 |
| Zhu, Y | 1 |
| Xia, Y | 1 |
| Ye, T | 1 |
| Shi, X | 1 |
| Song, X | 1 |
| Liu, L | 1 |
| Zeng, J | 1 |
| Wang, N | 1 |
| Luo, Y | 1 |
| Han, Y | 1 |
| Yu, L | 1 |
| Barreto, R | 1 |
| Waning, DL | 1 |
| Gao, H | 1 |
| Liu, Y | 1 |
| Zimmers, TA | 1 |
| Bonetto, A | 1 |
| Kirkland, SC | 1 |
| Ying, H | 1 |
| Zhang, YJ | 2 |
| Zhao, SL | 2 |
| Xiong, H | 1 |
| Nakano, K | 1 |
| Iwasaki, H | 1 |
| Kumagai, M | 1 |
| Wakabayashi, R | 1 |
| Yamasaki, A | 1 |
| Suzuki, H | 1 |
| Mibu, R | 1 |
| Onishi, H | 1 |
| Katano, M | 1 |
| Park, KS | 4 |
| Lee, NG | 1 |
| Lee, KH | 1 |
| Seo, JT | 1 |
| Choi, KY | 4 |
| Jeon, SH | 1 |
| Oh, JW | 2 |
| Pajak, B | 1 |
| Gajkowska, B | 1 |
| Orzechowski, A | 1 |
| Shen, GF | 1 |
| Zheng, Q | 1 |
| Zhu, HY | 1 |
| Chen, YC | 1 |
| Tsai, SH | 1 |
| Shen, SC | 1 |
| Lin, JK | 1 |
| Lee, WR | 1 |
| Kim, JA | 2 |
| Kim, HI | 1 |
| Oh, SY | 2 |
| Ahn, Y | 1 |
15 other studies available for pd 98059 and Colorectal Neoplasms
| Article | Year |
|---|---|
Intermittent low dose irradiation enhances the effectiveness of radio- and chemo-therapy for human colorectal adenocarcinoma cell line HT-29.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Benzothiazo | 2017 |
Downregulation of ZNF278 arrests the cell cycle and decreases the proliferation of colorectal cancer cells via inhibition of the ERK/MAPK pathway.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Colorectal Neoplasms; Extracellular Signal-Re | 2017 |
Annexin A3 depletion overcomes resistance to oxaliplatin in colorectal cancer via the MAPK signaling pathway.
Topics: Annexin A3; Anthracenes; Cell Line, Tumor; Cell Movement; Cell Survival; Colorectal Neoplasms; Down- | 2019 |
A novel small-molecule YLT205 induces apoptosis in human colorectal cells via mitochondrial apoptosis pathway in vitro and inhibits tumor growth in vivo.
Topics: Acetamides; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Benzoth | 2014 |
Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs.
Topics: Activin Receptors, Type II; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Compositio | 2016 |
Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells.
Topics: Antibodies, Neoplasm; Caco-2 Cells; Cell Differentiation; Colorectal Neoplasms; Enterocytes; Flavono | 2008 |
Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease | 2009 |
Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Proliferation; Chromones; Colo | 2011 |
The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc.
Topics: Animals; Cattle; Cell Division; Chlorides; Colorectal Neoplasms; Culture Media, Serum-Free; Cyclin D | 2003 |
p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells.
Topics: Bromodeoxyuridine; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; | 2004 |
Position of STAT-1 alpha in cycloheximide-dependent apoptosis triggered by TNF-alpha in human colorectal COLO 205 cancer cell line; role of polyphenolic compounds.
Topics: Apigenin; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Prolif | 2005 |
[Synergistic effect of rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells].
Topics: Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Prot | 2007 |
Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
Topics: Acetylcysteine; Arsenites; Blotting, Northern; Blotting, Western; Colorectal Neoplasms; Curcumin; Cy | 2001 |
Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells.
Topics: Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Nucleus; Chromans; Colorectal Neoplasms; C | 2002 |
Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells.
Topics: Chromones; Colorectal Neoplasms; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme A | 2002 |