pd 98059 has been researched along with Cirrhosis in 22 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 11 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 1 |
| Li, Y | 2 |
| Zhao, Z | 1 |
| Meng, Y | 1 |
| Bian, J | 1 |
| Bao, R | 1 |
| Zhu, K | 1 |
| Yang, T | 1 |
| Tang, CR | 1 |
| Luo, SG | 1 |
| Lin, X | 1 |
| Wang, J | 1 |
| Liu, Y | 1 |
| Sun, S | 1 |
| Ning, X | 1 |
| Zhai, Y | 1 |
| Du, R | 1 |
| Lu, Y | 1 |
| He, L | 1 |
| Li, R | 1 |
| Wu, W | 2 |
| Sun, W | 1 |
| Wang, H | 1 |
| Martín, P | 1 |
| Mora, I | 1 |
| Cortes, MA | 1 |
| Calleros, L | 1 |
| García-Jerez, A | 1 |
| Ortiz, A | 1 |
| Rodríguez-Puyol, M | 1 |
| Rodríguez-Puyol, D | 1 |
| Olmos, G | 1 |
| Deng, X | 1 |
| Jin, K | 1 |
| Gu, W | 1 |
| Liu, M | 1 |
| Zhou, L | 1 |
| Bell, HL | 1 |
| Gööz, M | 1 |
| Kothary, PC | 1 |
| Badhwar, J | 1 |
| Weng, C | 1 |
| Del Monte, MA | 1 |
| Muchir, A | 1 |
| Shan, J | 1 |
| Bonne, G | 1 |
| Worman, HJ | 1 |
| Guo, YS | 1 |
| Yuan, WJ | 1 |
| Zhang, AP | 1 |
| Ding, YH | 1 |
| Wang, YX | 1 |
| Ghosh, AK | 1 |
| Nagpal, V | 1 |
| Covington, JW | 1 |
| Michaels, MA | 1 |
| Vaughan, DE | 1 |
| Chen, LX | 1 |
| Yang, K | 1 |
| Sun, M | 1 |
| Chen, Q | 1 |
| Wang, ZH | 1 |
| Hu, GY | 1 |
| Tao, LJ | 1 |
| Akiyama-Uchida, Y | 1 |
| Ashizawa, N | 1 |
| Ohtsuru, A | 1 |
| Seto, S | 1 |
| Tsukazaki, T | 1 |
| Kikuchi, H | 1 |
| Yamashita, S | 1 |
| Yano, K | 1 |
| Flamant, M | 1 |
| Tharaux, PL | 1 |
| Placier, S | 1 |
| Henrion, D | 1 |
| Coffman, T | 1 |
| Chatziantoniou, C | 1 |
| Dussaule, JC | 1 |
| Dai, J | 1 |
| Xie, C | 1 |
| Vincent, R | 1 |
| Churg, A | 1 |
| Masamune, A | 1 |
| Kikuta, K | 1 |
| Satoh, M | 1 |
| Kume, K | 1 |
| Shimosegawa, T | 1 |
| Kapoun, AM | 1 |
| Liang, F | 1 |
| O'Young, G | 1 |
| Damm, DL | 1 |
| Quon, D | 1 |
| White, RT | 1 |
| Munson, K | 1 |
| Lam, A | 2 |
| Schreiner, GF | 2 |
| Protter, AA | 1 |
| Farias, E | 1 |
| Lu, M | 1 |
| Li, X | 1 |
| Schnapp, LM | 1 |
| Cho, SJ | 1 |
| Kang, MJ | 1 |
| Homer, RJ | 1 |
| Kang, HR | 1 |
| Zhang, X | 1 |
| Lee, PJ | 1 |
| Elias, JA | 1 |
| Lee, CG | 1 |
| Jung, JC | 1 |
| Huh, MI | 1 |
| Fini, ME | 1 |
| Hafizi, S | 1 |
| Chester, AH | 1 |
| Yacoub, MH | 1 |
| Chen, MM | 1 |
| Abraham, JA | 1 |
| Joly, AH | 1 |
| Douillet, CD | 1 |
| Velarde, V | 1 |
| Christopher, JT | 1 |
| Mayfield, RK | 1 |
| Trojanowska, ME | 1 |
| Jaffa, AA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study Of The Usage Of Statins In A Community Heart Failure Population: The Impact of HMG Co-Enzyme A Reductase Inhibitors on Heart Structural Parameters, Brain Naturetic Peptide, Markers of Inflammation and Fibrosis[NCT00795912] | Phase 4 | 56 participants (Actual) | Interventional | 2003-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
22 other studies available for pd 98059 and Cirrhosis
| Article | Year |
|---|---|
IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling.
Topics: Actins; Acute Kidney Injury; Albumins; Animals; Antigens, CD; Biomarkers; Blood Urea Nitrogen; Cadhe | 2019 |
Silenced miR-21 inhibits renal interstitial fibrosis via targeting ERK1/2 signaling pathway in mice.
Topics: Actins; Animals; Cell Line; Disease Models, Animal; Fibrosis; Flavonoids; Humans; Kidney Diseases; M | 2019 |
Egr-1 mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway.
Topics: Animals; Cadherins; Calcium-Binding Proteins; Cell Hypoxia; Cells, Cultured; Early Growth Response P | 2014 |
Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cells, Cultured; Cyclic GMP-Dependent Protein Kinase Type I | 2014 |
Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways.
Topics: Actins; Cell Line; Cell Proliferation; Collagen Type I; Fetus; Fibroblasts; Fibrosis; Flavonoids; Ge | 2015 |
ADAM-17 is activated by the mitogenic protein kinase ERK in a model of kidney fibrosis.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Fibrosis; Flavonoids; Gene Expression Regulation; Kidney Dis | 2010 |
Impaired intracellular signaling may allow up-regulation of CTGF-synthesis and secondary peri-retinal fibrosis in human retinal pigment epithelial cells from patients with age-related macular degeneration.
Topics: Carbon Radioisotopes; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Flavonoids; Gluco | 2010 |
Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
Topics: Animals; Anthracenes; Cardiomyopathy, Dilated; Fibrosis; Flavonoids; Heart Function Tests; Lamin Typ | 2011 |
Parathyroid hormone-mitogen-activated protein kinase axis exerts fibrogenic effect of connective tissue growth factor on human renal proximal tubular cells.
Topics: Cells, Cultured; Connective Tissue Growth Factor; Cyclic AMP-Dependent Protein Kinases; Extracellula | 2010 |
Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT.
Topics: Animals; Benzamides; Cell Transdifferentiation; Cells, Cultured; Dioxoles; Endothelial Cells; Extrac | 2012 |
Fluorofenidone inhibits transforming growth factor-beta1-induced cardiac myofibroblast differentiation.
Topics: Actins; Animals; Animals, Newborn; Blotting, Western; Cell Differentiation; Cell Separation; Cells, | 2012 |
Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.
Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Blotting, Western; Cell Division; Coll | 2002 |
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; | 2003 |
Air pollution particles produce airway wall remodeling in rat tracheal explants.
Topics: Air Pollution; alpha-Fetoproteins; Animals; Cells, Cultured; Chelating Agents; Collagen; Deferoxamin | 2003 |
Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells.
Topics: Animals; Becaplermin; Blotting, Western; Cell Division; Cell Movement; Chemotaxis; Enzyme Activation | 2003 |
B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation.
Topics: Adolescent; Blotting, Western; Butadienes; Cell Division; Cells, Cultured; Cyclic GMP; Enzyme Inhibi | 2004 |
Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.
Topics: Animals; Apoptosis; Blotting, Western; Cell Adhesion; Cell Line; Cell Survival; Cells, Cultured; Chr | 2005 |
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.
Topics: Animals; Bronchoalveolar Lavage; Caspases; Cell Death; Collagen; DNA; Early Growth Response Protein | 2006 |
Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma.
Topics: Animals; Cells, Cultured; Collagenases; Corneal Stroma; Enzyme Activation; Extracellular Signal-Regu | 2007 |
Inhibition of human cardiac fibroblast mitogenesis by blockade of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; Culture Med | 1999 |
CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis.
Topics: Adult; Aged; Animals; Animals, Newborn; Biomarkers; Blotting, Northern; Cells, Cultured; Colforsin; | 2000 |
Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: role of TGF-beta and MAPK.
Topics: Animals; Aorta; Bradykinin; Collagen; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Expression; Male | 2000 |