pd 98059 has been researched along with Cirrhosis in 22 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (4.55) | 18.2507 |
2000's | 10 (45.45) | 29.6817 |
2010's | 11 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Wang, X | 1 |
Li, Y | 2 |
Zhao, Z | 1 |
Meng, Y | 1 |
Bian, J | 1 |
Bao, R | 1 |
Zhu, K | 1 |
Yang, T | 1 |
Tang, CR | 1 |
Luo, SG | 1 |
Lin, X | 1 |
Wang, J | 1 |
Liu, Y | 1 |
Sun, S | 1 |
Ning, X | 1 |
Zhai, Y | 1 |
Du, R | 1 |
Lu, Y | 1 |
He, L | 1 |
Li, R | 1 |
Wu, W | 2 |
Sun, W | 1 |
Wang, H | 1 |
Martín, P | 1 |
Mora, I | 1 |
Cortes, MA | 1 |
Calleros, L | 1 |
García-Jerez, A | 1 |
Ortiz, A | 1 |
Rodríguez-Puyol, M | 1 |
Rodríguez-Puyol, D | 1 |
Olmos, G | 1 |
Deng, X | 1 |
Jin, K | 1 |
Gu, W | 1 |
Liu, M | 1 |
Zhou, L | 1 |
Bell, HL | 1 |
Gööz, M | 1 |
Kothary, PC | 1 |
Badhwar, J | 1 |
Weng, C | 1 |
Del Monte, MA | 1 |
Muchir, A | 1 |
Shan, J | 1 |
Bonne, G | 1 |
Worman, HJ | 1 |
Guo, YS | 1 |
Yuan, WJ | 1 |
Zhang, AP | 1 |
Ding, YH | 1 |
Wang, YX | 1 |
Ghosh, AK | 1 |
Nagpal, V | 1 |
Covington, JW | 1 |
Michaels, MA | 1 |
Vaughan, DE | 1 |
Chen, LX | 1 |
Yang, K | 1 |
Sun, M | 1 |
Chen, Q | 1 |
Wang, ZH | 1 |
Hu, GY | 1 |
Tao, LJ | 1 |
Akiyama-Uchida, Y | 1 |
Ashizawa, N | 1 |
Ohtsuru, A | 1 |
Seto, S | 1 |
Tsukazaki, T | 1 |
Kikuchi, H | 1 |
Yamashita, S | 1 |
Yano, K | 1 |
Flamant, M | 1 |
Tharaux, PL | 1 |
Placier, S | 1 |
Henrion, D | 1 |
Coffman, T | 1 |
Chatziantoniou, C | 1 |
Dussaule, JC | 1 |
Dai, J | 1 |
Xie, C | 1 |
Vincent, R | 1 |
Churg, A | 1 |
Masamune, A | 1 |
Kikuta, K | 1 |
Satoh, M | 1 |
Kume, K | 1 |
Shimosegawa, T | 1 |
Kapoun, AM | 1 |
Liang, F | 1 |
O'Young, G | 1 |
Damm, DL | 1 |
Quon, D | 1 |
White, RT | 1 |
Munson, K | 1 |
Lam, A | 2 |
Schreiner, GF | 2 |
Protter, AA | 1 |
Farias, E | 1 |
Lu, M | 1 |
Li, X | 1 |
Schnapp, LM | 1 |
Cho, SJ | 1 |
Kang, MJ | 1 |
Homer, RJ | 1 |
Kang, HR | 1 |
Zhang, X | 1 |
Lee, PJ | 1 |
Elias, JA | 1 |
Lee, CG | 1 |
Jung, JC | 1 |
Huh, MI | 1 |
Fini, ME | 1 |
Hafizi, S | 1 |
Chester, AH | 1 |
Yacoub, MH | 1 |
Chen, MM | 1 |
Abraham, JA | 1 |
Joly, AH | 1 |
Douillet, CD | 1 |
Velarde, V | 1 |
Christopher, JT | 1 |
Mayfield, RK | 1 |
Trojanowska, ME | 1 |
Jaffa, AA | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Study Of The Usage Of Statins In A Community Heart Failure Population: The Impact of HMG Co-Enzyme A Reductase Inhibitors on Heart Structural Parameters, Brain Naturetic Peptide, Markers of Inflammation and Fibrosis[NCT00795912] | Phase 4 | 56 participants (Actual) | Interventional | 2003-05-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
22 other studies available for pd 98059 and Cirrhosis
Article | Year |
---|---|
IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling.
Topics: Actins; Acute Kidney Injury; Albumins; Animals; Antigens, CD; Biomarkers; Blood Urea Nitrogen; Cadhe | 2019 |
Silenced miR-21 inhibits renal interstitial fibrosis via targeting ERK1/2 signaling pathway in mice.
Topics: Actins; Animals; Cell Line; Disease Models, Animal; Fibrosis; Flavonoids; Humans; Kidney Diseases; M | 2019 |
Egr-1 mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway.
Topics: Animals; Cadherins; Calcium-Binding Proteins; Cell Hypoxia; Cells, Cultured; Early Growth Response P | 2014 |
Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cells, Cultured; Cyclic GMP-Dependent Protein Kinase Type I | 2014 |
Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways.
Topics: Actins; Cell Line; Cell Proliferation; Collagen Type I; Fetus; Fibroblasts; Fibrosis; Flavonoids; Ge | 2015 |
ADAM-17 is activated by the mitogenic protein kinase ERK in a model of kidney fibrosis.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Fibrosis; Flavonoids; Gene Expression Regulation; Kidney Dis | 2010 |
Impaired intracellular signaling may allow up-regulation of CTGF-synthesis and secondary peri-retinal fibrosis in human retinal pigment epithelial cells from patients with age-related macular degeneration.
Topics: Carbon Radioisotopes; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Flavonoids; Gluco | 2010 |
Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
Topics: Animals; Anthracenes; Cardiomyopathy, Dilated; Fibrosis; Flavonoids; Heart Function Tests; Lamin Typ | 2011 |
Parathyroid hormone-mitogen-activated protein kinase axis exerts fibrogenic effect of connective tissue growth factor on human renal proximal tubular cells.
Topics: Cells, Cultured; Connective Tissue Growth Factor; Cyclic AMP-Dependent Protein Kinases; Extracellula | 2010 |
Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT.
Topics: Animals; Benzamides; Cell Transdifferentiation; Cells, Cultured; Dioxoles; Endothelial Cells; Extrac | 2012 |
Fluorofenidone inhibits transforming growth factor-beta1-induced cardiac myofibroblast differentiation.
Topics: Actins; Animals; Animals, Newborn; Blotting, Western; Cell Differentiation; Cell Separation; Cells, | 2012 |
Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.
Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Blotting, Western; Cell Division; Coll | 2002 |
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; | 2003 |
Air pollution particles produce airway wall remodeling in rat tracheal explants.
Topics: Air Pollution; alpha-Fetoproteins; Animals; Cells, Cultured; Chelating Agents; Collagen; Deferoxamin | 2003 |
Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells.
Topics: Animals; Becaplermin; Blotting, Western; Cell Division; Cell Movement; Chemotaxis; Enzyme Activation | 2003 |
B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation.
Topics: Adolescent; Blotting, Western; Butadienes; Cell Division; Cells, Cultured; Cyclic GMP; Enzyme Inhibi | 2004 |
Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.
Topics: Animals; Apoptosis; Blotting, Western; Cell Adhesion; Cell Line; Cell Survival; Cells, Cultured; Chr | 2005 |
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.
Topics: Animals; Bronchoalveolar Lavage; Caspases; Cell Death; Collagen; DNA; Early Growth Response Protein | 2006 |
Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma.
Topics: Animals; Cells, Cultured; Collagenases; Corneal Stroma; Enzyme Activation; Extracellular Signal-Regu | 2007 |
Inhibition of human cardiac fibroblast mitogenesis by blockade of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; Culture Med | 1999 |
CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis.
Topics: Adult; Aged; Animals; Animals, Newborn; Biomarkers; Blotting, Northern; Cells, Cultured; Colforsin; | 2000 |
Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: role of TGF-beta and MAPK.
Topics: Animals; Aorta; Bradykinin; Collagen; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Expression; Male | 2000 |