Page last updated: 2024-11-02

pd 98059 and Cirrhosis

pd 98059 has been researched along with Cirrhosis in 22 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.55)18.2507
2000's10 (45.45)29.6817
2010's11 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, X1
Li, Y2
Zhao, Z1
Meng, Y1
Bian, J1
Bao, R1
Zhu, K1
Yang, T1
Tang, CR1
Luo, SG1
Lin, X1
Wang, J1
Liu, Y1
Sun, S1
Ning, X1
Zhai, Y1
Du, R1
Lu, Y1
He, L1
Li, R1
Wu, W2
Sun, W1
Wang, H1
Martín, P1
Mora, I1
Cortes, MA1
Calleros, L1
García-Jerez, A1
Ortiz, A1
Rodríguez-Puyol, M1
Rodríguez-Puyol, D1
Olmos, G1
Deng, X1
Jin, K1
Gu, W1
Liu, M1
Zhou, L1
Bell, HL1
Gööz, M1
Kothary, PC1
Badhwar, J1
Weng, C1
Del Monte, MA1
Muchir, A1
Shan, J1
Bonne, G1
Worman, HJ1
Guo, YS1
Yuan, WJ1
Zhang, AP1
Ding, YH1
Wang, YX1
Ghosh, AK1
Nagpal, V1
Covington, JW1
Michaels, MA1
Vaughan, DE1
Chen, LX1
Yang, K1
Sun, M1
Chen, Q1
Wang, ZH1
Hu, GY1
Tao, LJ1
Akiyama-Uchida, Y1
Ashizawa, N1
Ohtsuru, A1
Seto, S1
Tsukazaki, T1
Kikuchi, H1
Yamashita, S1
Yano, K1
Flamant, M1
Tharaux, PL1
Placier, S1
Henrion, D1
Coffman, T1
Chatziantoniou, C1
Dussaule, JC1
Dai, J1
Xie, C1
Vincent, R1
Churg, A1
Masamune, A1
Kikuta, K1
Satoh, M1
Kume, K1
Shimosegawa, T1
Kapoun, AM1
Liang, F1
O'Young, G1
Damm, DL1
Quon, D1
White, RT1
Munson, K1
Lam, A2
Schreiner, GF2
Protter, AA1
Farias, E1
Lu, M1
Li, X1
Schnapp, LM1
Cho, SJ1
Kang, MJ1
Homer, RJ1
Kang, HR1
Zhang, X1
Lee, PJ1
Elias, JA1
Lee, CG1
Jung, JC1
Huh, MI1
Fini, ME1
Hafizi, S1
Chester, AH1
Yacoub, MH1
Chen, MM1
Abraham, JA1
Joly, AH1
Douillet, CD1
Velarde, V1
Christopher, JT1
Mayfield, RK1
Trojanowska, ME1
Jaffa, AA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Study Of The Usage Of Statins In A Community Heart Failure Population: The Impact of HMG Co-Enzyme A Reductase Inhibitors on Heart Structural Parameters, Brain Naturetic Peptide, Markers of Inflammation and Fibrosis[NCT00795912]Phase 456 participants (Actual)Interventional2003-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

22 other studies available for pd 98059 and Cirrhosis

ArticleYear
IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling.
    Acta biochimica et biophysica Sinica, 2019, Aug-05, Volume: 51, Issue:8

    Topics: Actins; Acute Kidney Injury; Albumins; Animals; Antigens, CD; Biomarkers; Blood Urea Nitrogen; Cadhe

2019
Silenced miR-21 inhibits renal interstitial fibrosis via targeting ERK1/2 signaling pathway in mice.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:3 Suppl

    Topics: Actins; Animals; Cell Line; Disease Models, Animal; Fibrosis; Flavonoids; Humans; Kidney Diseases; M

2019
Egr-1 mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway.
    American journal of nephrology, 2014, Volume: 39, Issue:5

    Topics: Animals; Cadherins; Calcium-Binding Proteins; Cell Hypoxia; Cells, Cultured; Early Growth Response P

2014
Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis.
    American journal of physiology. Renal physiology, 2014, Jul-01, Volume: 307, Issue:1

    Topics: Acute Kidney Injury; Animals; Apoptosis; Cells, Cultured; Cyclic GMP-Dependent Protein Kinase Type I

2014
Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 36, Issue:3

    Topics: Actins; Cell Line; Cell Proliferation; Collagen Type I; Fetus; Fibroblasts; Fibrosis; Flavonoids; Ge

2015
ADAM-17 is activated by the mitogenic protein kinase ERK in a model of kidney fibrosis.
    The American journal of the medical sciences, 2010, Volume: 339, Issue:2

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Fibrosis; Flavonoids; Gene Expression Regulation; Kidney Dis

2010
Impaired intracellular signaling may allow up-regulation of CTGF-synthesis and secondary peri-retinal fibrosis in human retinal pigment epithelial cells from patients with age-related macular degeneration.
    Advances in experimental medicine and biology, 2010, Volume: 664

    Topics: Carbon Radioisotopes; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Flavonoids; Gluco

2010
Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
    Circulation, 2011, Jan-04, Volume: 123, Issue:1

    Topics: Animals; Anthracenes; Cardiomyopathy, Dilated; Fibrosis; Flavonoids; Heart Function Tests; Lamin Typ

2011
Parathyroid hormone-mitogen-activated protein kinase axis exerts fibrogenic effect of connective tissue growth factor on human renal proximal tubular cells.
    Chinese medical journal, 2010, Volume: 123, Issue:24

    Topics: Cells, Cultured; Connective Tissue Growth Factor; Cyclic AMP-Dependent Protein Kinases; Extracellula

2010
Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT.
    Cellular signalling, 2012, Volume: 24, Issue:5

    Topics: Animals; Benzamides; Cell Transdifferentiation; Cells, Cultured; Dioxoles; Endothelial Cells; Extrac

2012
Fluorofenidone inhibits transforming growth factor-beta1-induced cardiac myofibroblast differentiation.
    Die Pharmazie, 2012, Volume: 67, Issue:5

    Topics: Actins; Animals; Animals, Newborn; Blotting, Western; Cell Differentiation; Cell Separation; Cells,

2012
Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:2

    Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Blotting, Western; Cell Division; Coll

2002
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:2

    Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors;

2003
Air pollution particles produce airway wall remodeling in rat tracheal explants.
    American journal of respiratory cell and molecular biology, 2003, Volume: 29, Issue:3 Pt 1

    Topics: Air Pollution; alpha-Fetoproteins; Animals; Cells, Cultured; Chelating Agents; Collagen; Deferoxamin

2003
Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells.
    The Tohoku journal of experimental medicine, 2003, Volume: 199, Issue:2

    Topics: Animals; Becaplermin; Blotting, Western; Cell Division; Cell Movement; Chemotaxis; Enzyme Activation

2003
B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation.
    Circulation research, 2004, Mar-05, Volume: 94, Issue:4

    Topics: Adolescent; Blotting, Western; Butadienes; Cell Division; Cells, Cultured; Cyclic GMP; Enzyme Inhibi

2004
Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.
    Biochemical and biophysical research communications, 2005, Apr-01, Volume: 329, Issue:1

    Topics: Animals; Apoptosis; Blotting, Western; Cell Adhesion; Cell Line; Cell Survival; Cells, Cultured; Chr

2005
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.
    The Journal of biological chemistry, 2006, Mar-24, Volume: 281, Issue:12

    Topics: Animals; Bronchoalveolar Lavage; Caspases; Cell Death; Collagen; DNA; Early Growth Response Protein

2006
Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma.
    Journal of cellular biochemistry, 2007, Oct-01, Volume: 102, Issue:2

    Topics: Animals; Cells, Cultured; Collagenases; Corneal Stroma; Enzyme Activation; Extracellular Signal-Regu

2007
Inhibition of human cardiac fibroblast mitogenesis by blockade of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
    Clinical and experimental pharmacology & physiology, 1999, Volume: 26, Issue:7

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromones; Culture Med

1999
CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:10

    Topics: Adult; Aged; Animals; Animals, Newborn; Biomarkers; Blotting, Northern; Cells, Cultured; Colforsin;

2000
Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: role of TGF-beta and MAPK.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:6

    Topics: Animals; Aorta; Bradykinin; Collagen; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Expression; Male

2000