pd 98059 has been researched along with Chronic Disease in 6 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Angiotensin II (Ang II), acting via angiotensin type 1 receptors in the brain, activates the sympathetic nervous system in heart failure (HF)." | 7.74 | Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats. ( Felder, RB; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH, 2008) |
| "Angiotensin II (Ang II), acting via angiotensin type 1 receptors in the brain, activates the sympathetic nervous system in heart failure (HF)." | 3.74 | Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats. ( Felder, RB; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH, 2008) |
| " All experimental conditions were determined by dose-response and time-course experiments." | 1.35 | Regulation of matrix contraction in chronic venous disease. ( Durán, WN; Lal, BK; Ohara, N; Pappas, PJ; Saito, S; Zapiach, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, C | 1 |
| Li, N | 1 |
| Yuan, Y | 1 |
| Wang, R | 1 |
| Chen, J | 1 |
| Yang, J | 1 |
| Guo, Z | 1 |
| Wang, S | 1 |
| Zhang, Y | 1 |
| Liu, Y | 1 |
| Dong, J | 1 |
| Wei, SG | 1 |
| Yu, Y | 1 |
| Zhang, ZH | 1 |
| Weiss, RM | 1 |
| Felder, RB | 1 |
| Chang, K | 1 |
| Xiao, D | 1 |
| Huang, X | 1 |
| Longo, LD | 1 |
| Zhang, L | 1 |
| Pappas, PJ | 1 |
| Lal, BK | 1 |
| Ohara, N | 1 |
| Saito, S | 1 |
| Zapiach, L | 1 |
| Durán, WN | 1 |
| Wang, HT | 1 |
| Han, F | 1 |
| Gao, JL | 1 |
| Shi, YX | 1 |
| Aoki, K | 1 |
| Zubkov, AY | 1 |
| Tibbs, RE | 1 |
| Zhang, JH | 1 |
6 other studies available for pd 98059 and Chronic Disease
| Article | Year |
|---|---|
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pres | 2018 |
Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats.
Topics: Acute Disease; Analysis of Variance; Angiotensin II; Animals; Chronic Disease; Disease Models, Anima | 2008 |
Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway.
Topics: Altitude; Animals; Arteries; Blood Pressure; Calcium; Carcinogens; Chronic Disease; Enzyme Inhibitor | 2009 |
Regulation of matrix contraction in chronic venous disease.
Topics: Actins; Case-Control Studies; Cells, Cultured; Chronic Disease; Collagen; Dose-Response Relationship | 2009 |
Increased phosphorylation of extracellular signal-regulated kinase in the medial prefrontal cortex of the single-prolonged stress rats.
Topics: Animals; Anxiety; Behavior, Animal; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Extr | 2010 |
Role of MAPK in chronic cerebral vasospasm.
Topics: Animals; Blood Pressure; Chronic Disease; Dimethyl Sulfoxide; Dogs; Female; Flavonoids; Male; Mitoge | 2002 |