pd 98059 has been researched along with Choriocarcinoma in 4 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leptin and glucose effect on cell growth has been investigated in the JAr human choriocarcinoma cells." | 7.72 | Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion. ( Beguinot, F; Bifulco, G; Caruso, M; di Carlo, C; Miele, C; Nappi, C; Tommaselli, GA; Trencia, A, 2003) |
| "Leptin and glucose effect on cell growth has been investigated in the JAr human choriocarcinoma cells." | 3.72 | Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion. ( Beguinot, F; Bifulco, G; Caruso, M; di Carlo, C; Miele, C; Nappi, C; Tommaselli, GA; Trencia, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maymó, JL | 1 |
| Pérez Pérez, A | 1 |
| Sánchez-Margalet, V | 1 |
| Dueñas, JL | 1 |
| Calvo, JC | 1 |
| Varone, CL | 1 |
| Suzuki, T | 1 |
| Ino, K | 1 |
| Kikkawa, F | 1 |
| Uehara, C | 1 |
| Kajiyama, H | 1 |
| Shibata, K | 1 |
| Mizutani, S | 1 |
| Bifulco, G | 1 |
| Trencia, A | 1 |
| Caruso, M | 1 |
| Tommaselli, GA | 1 |
| Miele, C | 1 |
| di Carlo, C | 1 |
| Beguinot, F | 1 |
| Nappi, C | 1 |
| Al-Shami, R | 1 |
| Sorensen, ES | 1 |
| Ek-Rylander, B | 1 |
| Andersson, G | 1 |
| Carson, DD | 1 |
| Farach-Carson, MC | 1 |
4 other studies available for pd 98059 and Choriocarcinoma
| Article | Year |
|---|---|
Up-regulation of placental leptin by human chorionic gonadotropin.
Topics: Androstadienes; Cell Line, Tumor; Cesarean Section; Choriocarcinoma; Chorionic Gonadotropin; Deliver | 2009 |
Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway.
Topics: Antigens, Differentiation; Cell Membrane; Cell Transformation, Neoplastic; Choriocarcinoma; Chorioni | 2002 |
Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion.
Topics: Cell Division; Choriocarcinoma; DNA; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inh | 2003 |
Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway.
Topics: Blotting, Western; Cell Line, Tumor; Choriocarcinoma; Chromones; Enzyme Activation; Enzyme Inhibitor | 2005 |