pd 98059 has been researched along with Cell Transformation, Neoplastic in 45 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The actin remodeling effect was more prominent at lower dosage levels (1/8-1/4 of IC(50)), which was accompanied by an increased cell adhesion and decreased motility." | 1.33 | Effect of an epidermal growth factor receptor tyrosine kinase inhibitor on actin remodeling in an in vitro bladder cancer carcinogenesis model. ( Belldegrun, A; Figlin, R; Iwata, KK; Jin, Y; Lieberman, R; Pantuck, A; Rao, J; Zhang, ZF, 2006) |
| "Human hepatocellular carcinoma (HCC) is associated with increased expression and activity of mitogen-activated protein kinase (MAPK) signaling intermediates (ie, MEK, ERK)." | 1.32 | Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma. ( Schmidt, CM; Wang, Y; Wiesenauer, CA; Yip-Schneider, MT, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (13.33) | 18.2507 |
| 2000's | 33 (73.33) | 29.6817 |
| 2010's | 6 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rho, O | 1 |
| Kiguchi, K | 1 |
| Jiang, G | 1 |
| DiGiovanni, J | 1 |
| Rao, W | 1 |
| Xie, G | 1 |
| Zhang, Y | 3 |
| Wang, S | 1 |
| Wang, Y | 3 |
| Zhang, H | 1 |
| Song, F | 1 |
| Zhang, R | 2 |
| Yin, Q | 1 |
| Shen, L | 1 |
| Ge, H | 1 |
| Fukazawa, H | 2 |
| Ikeda, Y | 1 |
| Fukuyama, M | 1 |
| Suzuki, T | 3 |
| Hori, H | 1 |
| Okuda, T | 1 |
| Uehara, Y | 2 |
| Song, EJ | 1 |
| Kang, MJ | 1 |
| Kim, YS | 1 |
| Kim, SM | 1 |
| Lee, SE | 1 |
| Kim, CH | 1 |
| Kim, DJ | 1 |
| Park, JH | 1 |
| Li, L | 1 |
| Guo, X | 1 |
| Jin, X | 1 |
| Sun, W | 1 |
| Zhang, X | 1 |
| Xu, RC | 1 |
| Wu, R | 1 |
| Duan, L | 1 |
| Ye, L | 1 |
| Wang, H | 1 |
| Yang, X | 1 |
| Chen, X | 1 |
| Weng, Y | 1 |
| Luo, J | 1 |
| Tang, M | 1 |
| Shi, Q | 1 |
| He, T | 1 |
| Zhou, L | 1 |
| Ino, K | 1 |
| Kikkawa, F | 1 |
| Uehara, C | 1 |
| Kajiyama, H | 1 |
| Shibata, K | 1 |
| Mizutani, S | 1 |
| Sanna, B | 1 |
| Debidda, M | 1 |
| Pintus, G | 1 |
| Tadolini, B | 1 |
| Posadino, AM | 1 |
| Bennardini, F | 1 |
| Sava, G | 1 |
| Ventura, C | 1 |
| Santibáñez, JF | 2 |
| Guerrero, J | 2 |
| Quintanilla, M | 1 |
| Fabra, A | 1 |
| Martínez, J | 2 |
| Katsanakis, KD | 1 |
| Gorgoulis, V | 1 |
| Papavassiliou, AG | 1 |
| Zoumpourlis, VK | 1 |
| Agazie, YM | 1 |
| Movilla, N | 1 |
| Ischenko, I | 1 |
| Hayman, MJ | 1 |
| Olivares, D | 1 |
| Wiesenauer, CA | 1 |
| Yip-Schneider, MT | 1 |
| Schmidt, CM | 1 |
| Tchernitsa, OI | 1 |
| Sers, C | 1 |
| Zuber, J | 1 |
| Hinzmann, B | 1 |
| Grips, M | 1 |
| Schramme, A | 1 |
| Lund, P | 1 |
| Schwendel, A | 1 |
| Rosenthal, A | 1 |
| Schäfer, R | 1 |
| Drosopoulos, KG | 1 |
| Roberts, ML | 1 |
| Cermak, L | 1 |
| Sasazuki, T | 1 |
| Shirasawa, S | 1 |
| Andera, L | 1 |
| Pintzas, A | 1 |
| Moissoglu, K | 1 |
| Sachdev, S | 1 |
| Gelman, IH | 1 |
| Pruitt, K | 2 |
| Ulkü, AS | 1 |
| Frantz, K | 1 |
| Rojas, RJ | 1 |
| Muniz-Medina, VM | 1 |
| Rangnekar, VM | 2 |
| Der, CJ | 3 |
| Shields, JM | 1 |
| Jin, Y | 1 |
| Iwata, KK | 1 |
| Belldegrun, A | 1 |
| Figlin, R | 1 |
| Pantuck, A | 1 |
| Zhang, ZF | 1 |
| Lieberman, R | 1 |
| Rao, J | 1 |
| Puppala, D | 1 |
| Gairola, CG | 1 |
| Swanson, HI | 1 |
| Grossoni, VC | 1 |
| Falbo, KB | 1 |
| Mauro, LV | 1 |
| Krasnapolski, MA | 1 |
| Kazanietz, MG | 1 |
| Bal De Kier Joffé, ED | 1 |
| Urtreger, AJ | 1 |
| Liang, FP | 1 |
| Lin, CH | 1 |
| Kuo, CD | 1 |
| Chao, HP | 1 |
| Fu, SL | 1 |
| Grossi, M | 1 |
| La Rocca, SA | 1 |
| Pierluigi, G | 1 |
| Vannucchi, S | 1 |
| Ruaro, EM | 1 |
| Schneider, C | 1 |
| Tatò, F | 1 |
| Edamatsu, H | 1 |
| Kaziro, Y | 1 |
| Itoh, H | 1 |
| Bergman, AC | 1 |
| Alaiya, AA | 1 |
| Wendler, W | 1 |
| Binetruy, B | 1 |
| Shoshan, M | 1 |
| Sakaguchi, K | 1 |
| Bergman, T | 1 |
| Kronenwett, U | 1 |
| Auer, G | 1 |
| Appella, E | 1 |
| Jörnvall, H | 1 |
| Linder, S | 1 |
| Hartkamp, J | 1 |
| Troppmair, J | 1 |
| Rapp, UR | 1 |
| Quilliam, LA | 1 |
| Castro, AF | 1 |
| Rogers-Graham, KS | 1 |
| Martin, CB | 1 |
| Bi, C | 1 |
| Qiu, SG | 1 |
| Krishnan, S | 1 |
| el-Guendy, N | 1 |
| Rak, J | 1 |
| Mitsuhashi, Y | 1 |
| Sheehan, C | 1 |
| Tamir, A | 1 |
| Viloria-Petit, A | 1 |
| Filmus, J | 1 |
| Mansour, SJ | 1 |
| Ahn, NG | 1 |
| Kerbel, RS | 1 |
| Blalock, WL | 1 |
| Pearce, M | 1 |
| Steelman, LS | 1 |
| Franklin, RA | 1 |
| McCarthy, SA | 1 |
| Cherwinski, H | 1 |
| McMahon, M | 2 |
| McCubrey, JA | 1 |
| Kim, YN | 1 |
| Wiepz, GJ | 1 |
| Guadarrama, AG | 1 |
| Bertics, PJ | 1 |
| Okajima, E | 1 |
| Thorgeirsson, UP | 1 |
| Tan, Z | 1 |
| Liang, P | 1 |
| Mirza, AM | 1 |
| Kohn, AD | 1 |
| Roth, RA | 1 |
| Cristofanelli, B | 1 |
| Valentinis, B | 1 |
| Soddu, S | 1 |
| Rizzo, MG | 1 |
| Marchetti, A | 1 |
| Bossi, G | 1 |
| Morena, AR | 1 |
| Dews, M | 1 |
| Baserga, R | 1 |
| Sacchi, A | 1 |
| Silvany, RE | 1 |
| Eliazer, S | 1 |
| Wolff, NC | 1 |
| Ilaria, RL | 1 |
| Nguyen, KT | 2 |
| Wang, WJ | 1 |
| Chan, JL | 2 |
| Wang, LH | 2 |
| Reuveni, H | 1 |
| Geiger, T | 1 |
| Geiger, B | 1 |
| Levitzki, A | 1 |
| Su, Z | 1 |
| Shi, Y | 1 |
| Friedman, R | 1 |
| Qiao, L | 1 |
| McKinstry, R | 1 |
| Hinman, D | 1 |
| Dent, P | 1 |
| Fisher, PB | 1 |
| Joseph, P | 2 |
| Muchnok, TK | 1 |
| Klishis, ML | 1 |
| Roberts, JR | 1 |
| Antonini, JM | 1 |
| Whong, WZ | 1 |
| Ong , T | 1 |
| Muchnok, T | 1 |
| Ong, T | 1 |
| Zong, CS | 1 |
| Uttamsingh, S | 1 |
| Sachdev, P | 1 |
| Bhanot, M | 1 |
| Le, MT | 1 |
| Hirayama, E | 1 |
| Isobe, A | 1 |
| Kajihara, Y | 1 |
| Kim, J | 1 |
| Hamaguchi, M | 1 |
| K-Tsuzuku, J | 1 |
| Ajima, R | 1 |
| Nakamura, T | 1 |
| Yoshida, Y | 1 |
| Yamamoto, T | 1 |
| Pruitt, WM | 1 |
| Bilter, GK | 1 |
| Westwick, JK | 1 |
45 other studies available for pd 98059 and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell | 2014 |
OVA66, a tumor associated protein, induces oncogenic transformation of NIH3T3 cells.
Topics: Animals; Antigens, Neoplasm; Cell Transformation, Neoplastic; Chromones; Flavonoids; HeLa Cells; Hum | 2014 |
The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells.
Topics: Animals; Butadienes; Cell Line, Tumor; Cell Transformation, Neoplastic; Extracellular Signal-Regulat | 2010 |
Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5.
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Flagellin; Flavonoids; Humans; Interleukin-8; MAP | 2011 |
Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells.
Topics: Androstadienes; Apoptosis; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Tra | 2012 |
S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway.
Topics: Animals; Calgranulin B; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transf | 2013 |
Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway.
Topics: Antigens, Differentiation; Cell Membrane; Cell Transformation, Neoplastic; Choriocarcinoma; Chorioni | 2002 |
The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Transformation, Neop | 2002 |
Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Curcumin; Dipeptides; Enzyme Inhib | 2002 |
The progression in the mouse skin carcinogenesis model correlates with ERK1/2 signaling.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Flavonoids; Genes, ras; Immunohist | 2002 |
The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinas | 2003 |
Cyclic AMP inhibits TGFbeta1-induced cell-scattering and invasiveness in murine-transformed keratinocytes.
Topics: Animals; Cell Line, Transformed; Cell Movement; Cell Transformation, Neoplastic; Colforsin; Cyclic A | 2003 |
Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma.
Topics: Apoptosis; Blotting, Western; Butadienes; Carcinoma, Hepatocellular; Cell Count; Cell Division; Cell | 2004 |
Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells.
Topics: Animals; Cell Transformation, Neoplastic; Chromones; Enzyme Inhibitors; Epithelial Cells; Female; Fl | 2004 |
Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.
Topics: Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Separation; Cell Su | 2005 |
Enhanced v-Src-induced oncogenic transformation in the absence of focal adhesion kinase is mediated by phosphatidylinositol 3-kinase.
Topics: Animals; Cell Adhesion; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Enzyme Activ | 2005 |
Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.
Topics: Agar; Alleles; Animals; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Blotting, Northern; B | 2005 |
Effect of an epidermal growth factor receptor tyrosine kinase inhibitor on actin remodeling in an in vitro bladder cancer carcinogenesis model.
Topics: Actins; Anticarcinogenic Agents; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Tra | 2006 |
Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation.
Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Transformation, Neoplasti | 2007 |
Protein kinase C delta inhibits the production of proteolytic enzymes in murine mammary cells.
Topics: Animals; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Down-Regulation; Flavonoids; Mam | 2007 |
Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.
Topics: Antiviral Agents; Butadienes; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; | 2008 |
Role of Gas1 down-regulation in mitogenic stimulation of quiescent NIH3T3 cells by v-Src.
Topics: 3T3 Cells; Animals; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Chromones; | 1998 |
Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Transformation, Neoplastic; E | 1998 |
Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Line, Transformed; Cel | 1999 |
The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion.
Topics: 3T3 Cells; Animals; Antigens, Polyomavirus Transforming; Binding Sites; Calcium-Calmodulin-Dependent | 1999 |
M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cell Differen | 1999 |
Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation.
Topics: 3T3 Cells; Animals; Apoptosis Regulatory Proteins; Carrier Proteins; Cell Transformation, Neoplastic | 1999 |
Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chromones; Endothelia | 2000 |
A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.
Topics: Animals; Antibodies, Monoclonal; Autocrine Communication; Cell Division; Cell Line; Cell Transformat | 2000 |
Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status.
Topics: Animals; Caveolin 1; Caveolins; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Rela | 2000 |
Different regulation of vascular endothelial growth factor expression by the ERK and p38 kinase pathways in v-ras, v-raf, and v-myc transformed cells.
Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma; Cell Line; Cell | 2000 |
U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways.
Topics: Animals; Butadienes; Cell Line, Transformed; Cell Size; Cell Transformation, Neoplastic; Contact Inh | 2000 |
Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Line; Cell Transformation, Neopl | 2000 |
Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB.
Topics: Animals; Apoptosis; Blotting, Western; Cell Adhesion; Cell Cycle; Cell Cycle Proteins; Cell Line; Ce | 2000 |
Cooperative transformation of 32D cells by the combined expression of IRS-1 and V-Ha-Ras.
Topics: Androstadienes; Animals; Cell Differentiation; Cell Survival; Cell Transformation, Neoplastic; Chrom | 2000 |
Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.
Topics: 3T3 Cells; Animals; Binding Sites; Bone Neoplasms; Butadienes; Cell Transformation, Neoplastic; Colo | 2000 |
Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Tra | 2000 |
Reversal of the Ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway.
Topics: 3T3 Cells; Adherens Junctions; Alkyl and Aryl Transferases; Animals; Calcium-Calmodulin-Dependent Pr | 2000 |
PEA3 sites within the progression elevated gene-3 (PEG-3) promoter and mitogen-activated protein kinase contribute to differential PEG-3 expression in Ha-ras and v-raf oncogene transformed rat embryo cells.
Topics: Animals; Antigens, Differentiation; Base Sequence; Cell Line, Transformed; Cell Transformation, Neop | 2001 |
Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species.
Topics: 3T3 Cells; Analysis of Variance; Animals; Blotting, Northern; Cadmium; Calcium; Cell Transformation, | 2001 |
Gene expression profile in BALB/c-3T3 cells transformed with beryllium sulfate.
Topics: 3T3 Cells; Animals; Beryllium; Calcium-Calmodulin-Dependent Protein Kinases; Catalase; Cell Transfor | 2001 |
The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Chr | 2002 |
Ras/MAP kinase pathway is associated with the control of myotube formation but not myofibril assembly in quail myoblasts transformed with Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultur | 2001 |
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
Topics: 3T3 Cells; Alanine; Animals; Carrier Proteins; Cell Cycle; Cell Division; Cell Transformation, Neopl | 2002 |
Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; | 2002 |