pd 98059 has been researched along with Cardiac Hypertrophy in 26 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate the role of angiotensin II (Ang II), a major inducer of cardiac hypertrophy, in the reexpression of T-type channel in left ventricular hypertrophied myocytes." | 3.72 | Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels. ( Capuano, V; Coulombe, A; Deroubaix, E; Ferron, L; Renaud, JF; Ruchon, Y, 2003) |
| "We showed before that in neonatal rat cardiac myocytes partial inhibition of Na+/K+-ATPase by nontoxic concentrations of ouabain causes hypertrophic growth and transcriptional regulations of genes that are markers of cardiac hypertrophy." | 3.70 | Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. ( Askari, A; Gnudi, L; Kahn, BB; Kometiani, P; Li, J; Xie, Z, 1998) |
| "In an in vitro model of PE-induced cardiac hypertrophy, Selumetinib significantly inhibited the ERK activation and prevented enlargement of cardiomyocytes or reactivation of certain fetal genes." | 1.43 | Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway. ( Cai, H; Chen, L; Chen, Z; Li, C; Li, S; Li, Y; Long, D; Luo, F; Rao, L; Yang, H; You, G; Zhang, Q, 2016) |
| "PD98059 attenuates PTH induced cardiac hypertrophy in vitro via inhibiting the expression of ERK1/2 and p-ERK1/2." | 1.35 | [Parathyroid hormone 1-34 induce cardiac myocytes hypertrophy via extracellular regulated protein kinase 1/2 pathway]. ( An, HX; Liu, SY; Liu, XG; Ren, YP; Zhang, WB, 2008) |
| "Cardiac hypertrophy is associated with specific alterations in myocardial gene expression; however, the exact mechanisms responsible for altered gene expression are poorly defined." | 1.31 | Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. ( Babu, GJ; Lalli, MJ; Periasamy, M; Sadoshima, J; Sussman, MA, 2000) |
| "Many hormones and growth factors induce cardiac hypertrophy via activation of members of the phospholipase C (PLC) family." | 1.31 | Differential regulation of phospholipase C-beta isozymes in cardiomyocyte hypertrophy. ( Böhm, M; Geisler, M; Mies, F; Nohr, T; Schnabel, P, 2000) |
| "Cardiac hypertrophy is characterized by increased cardiomyocyte protein synthesis, increased cell volume, and a shift in cardiac-specific gene expression to fetal isoforms." | 1.31 | Role and relation of p70 S6 and extracellular signal-regulated kinases in the phenotypic changes of hypertrophy of cardiac myocytes. ( Abe, S; Adachi, S; Hiroe, M; Ito, H; Marumo, F; Nozato, T; Ono, Y; Tamamori, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (38.46) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 6 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, Y | 1 |
| Liang, C | 1 |
| Luo, Y | 1 |
| Xing, W | 1 |
| Zhang, T | 1 |
| Ding, F | 1 |
| Yu, L | 1 |
| Wang, M | 1 |
| Xu, S | 2 |
| Xia, Q | 1 |
| Fu, G | 1 |
| Abdelhamid, G | 1 |
| El-Kadi, AO | 1 |
| Huang, Q | 1 |
| Huang, J | 1 |
| Zeng, Z | 1 |
| Luo, J | 1 |
| Liu, P | 1 |
| Chen, S | 1 |
| Liu, B | 1 |
| Pan, X | 1 |
| Zang, L | 1 |
| Zhou, S | 1 |
| Xie, F | 1 |
| Liu, W | 1 |
| Feng, F | 1 |
| Li, X | 1 |
| He, L | 1 |
| Lv, D | 1 |
| Qin, X | 1 |
| Li, L | 2 |
| Chen, L | 2 |
| Li, C | 1 |
| Chen, Z | 1 |
| Yang, H | 1 |
| Luo, F | 1 |
| Cai, H | 1 |
| Li, Y | 1 |
| You, G | 1 |
| Long, D | 1 |
| Li, S | 1 |
| Zhang, Q | 1 |
| Rao, L | 1 |
| Liu, XG | 1 |
| An, HX | 1 |
| Liu, SY | 1 |
| Ren, YP | 1 |
| Zhang, WB | 1 |
| Javadov, S | 1 |
| Rajapurohitam, V | 1 |
| Kilić, A | 1 |
| Zeidan, A | 1 |
| Choi, A | 1 |
| Karmazyn, M | 1 |
| Ferron, L | 1 |
| Capuano, V | 1 |
| Ruchon, Y | 1 |
| Deroubaix, E | 1 |
| Coulombe, A | 1 |
| Renaud, JF | 1 |
| Takahashi, N | 1 |
| Saito, Y | 1 |
| Kuwahara, K | 1 |
| Harada, M | 1 |
| Tanimoto, K | 1 |
| Nakagawa, Y | 1 |
| Kawakami, R | 1 |
| Nakanishi, M | 1 |
| Yasuno, S | 1 |
| Usami, S | 1 |
| Yoshimura, A | 1 |
| Nakao, K | 1 |
| Kumbar, DH | 1 |
| VanBergen, A | 1 |
| Ocampo, C | 1 |
| Muangmingsuk, S | 1 |
| Griffin, AJ | 1 |
| Gupta, M | 1 |
| Post, GR | 1 |
| Goldstein, D | 1 |
| Thuerauf, DJ | 1 |
| Glembotski, CC | 1 |
| Brown, JH | 1 |
| Thorburn, J | 1 |
| Thorburn, A | 3 |
| Lavandero, S | 1 |
| Foncea, R | 1 |
| Pérez, V | 1 |
| Sapag-Hagar, M | 1 |
| Yamazaki, T | 1 |
| Komuro, I | 1 |
| Kudoh, S | 1 |
| Zou, Y | 1 |
| Nagai, R | 1 |
| Aikawa, R | 1 |
| Uozumi, H | 1 |
| Yazaki, Y | 1 |
| Hines, WA | 1 |
| Kometiani, P | 1 |
| Li, J | 1 |
| Gnudi, L | 1 |
| Kahn, BB | 1 |
| Askari, A | 1 |
| Xie, Z | 1 |
| Choukroun, G | 1 |
| Hajjar, R | 1 |
| Kyriakis, JM | 1 |
| Bonventre, JV | 1 |
| Rosenzweig, A | 1 |
| Force, T | 1 |
| Murata, M | 2 |
| Fukuda, K | 2 |
| Ishida, H | 1 |
| Miyoshi, S | 1 |
| Koura, T | 1 |
| Kodama, H | 2 |
| Nakazawa, HK | 1 |
| Ogawa, S | 2 |
| Montessuit, C | 1 |
| Schlüter, KD | 1 |
| Simm, A | 1 |
| Schäfer, M | 1 |
| Taimor, G | 1 |
| Piper, HM | 1 |
| Babu, GJ | 1 |
| Lalli, MJ | 1 |
| Sussman, MA | 1 |
| Sadoshima, J | 1 |
| Periasamy, M | 1 |
| Schnabel, P | 1 |
| Mies, F | 1 |
| Nohr, T | 1 |
| Geisler, M | 1 |
| Böhm, M | 1 |
| Ono, Y | 1 |
| Ito, H | 1 |
| Tamamori, M | 1 |
| Nozato, T | 1 |
| Adachi, S | 1 |
| Abe, S | 1 |
| Marumo, F | 1 |
| Hiroe, M | 1 |
| Pan, J | 1 |
| Sano, M | 1 |
| Takahashi, T | 1 |
| Kato, T | 1 |
| Makino, S | 1 |
| Manabe, T | 1 |
| Xiao, L | 1 |
| Pimental, DR | 1 |
| Amin, JK | 1 |
| Singh, K | 1 |
| Sawyer, DB | 1 |
| Colucci, WS | 1 |
26 other studies available for pd 98059 and Cardiac Hypertrophy
| Article | Year |
|---|---|
Possible mechanism of GATA4 inhibiting myocardin activity during cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cells, Cultured; Chlorocebus aethiops; C | 2019 |
O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2.
Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Cardiomegaly; Cyclin D2; Diabetes Mellitus, Exper | 2013 |
Buthionine sulfoximine, an inhibitor of glutathione biosynthesis, induces expression of soluble epoxide hydrolase and markers of cellular hypertrophy in a rat cardiomyoblast cell line: roles of the NF-κB and MAPK signaling pathways.
Topics: Animals; Antioxidants; Atrial Natriuretic Factor; Butadienes; Buthionine Sulfoximine; Cardiomegaly; | 2015 |
Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Topics: Animals; Animals, Newborn; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Ac | 2015 |
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
Topics: Animals; Apelin; Autophagy; Cardiomegaly; Cell Line; Chromones; Enzyme Inhibitors; Extracellular Sig | 2015 |
Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Aorta; Apoptosis; Benzimidazoles; Cardiomegaly | 2016 |
[Parathyroid hormone 1-34 induce cardiac myocytes hypertrophy via extracellular regulated protein kinase 1/2 pathway].
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Flavonoids; Gene Expression Regul | 2008 |
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cardiomegaly; | 2009 |
Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Bosentan; Butadienes; C | 2003 |
Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes.
Topics: Animals; Cardiomegaly; Cells, Cultured; Cytokines; DNA-Binding Proteins; Flavonoids; MAP Kinase Kina | 2005 |
Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals | 2007 |
Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes.
Topics: Actin Cytoskeleton; Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Animals, Newborn; At | 1996 |
MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells.
Topics: 3T3 Cells; Actins; ADP Ribose Transferases; Animals; Atrial Natriuretic Factor; Botulinum Toxins; Ca | 1997 |
Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegal | 1998 |
Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy.
Topics: Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Ki | 1998 |
Ras and rho are required for galphaq-induced hypertrophic gene expression in neonatal rat cardiac myocytes.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; | 1998 |
Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases.
Topics: Actins; Atrial Natriuretic Factor; Calcium; Calmodulin; Cardiomegaly; Cell Division; Cells, Cultured | 1998 |
Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.
Topics: Adenoviridae; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; | 1998 |
Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, enhances L-type Ca2+ current and [Ca2+]i transient in cardiomyocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protei | 1999 |
Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists.
Topics: Animals; Cardiomegaly; Cell Cycle Proteins; Cells, Cultured; Dual Specificity Phosphatase 1; Dual Sp | 1999 |
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Carcino | 1999 |
Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cell Nucleus; | 2000 |
Differential regulation of phospholipase C-beta isozymes in cardiomyocyte hypertrophy.
Topics: Androstadienes; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavono | 2000 |
Role and relation of p70 S6 and extracellular signal-regulated kinases in the phenotypic changes of hypertrophy of cardiac myocytes.
Topics: Actins; Animals; Cardiomegaly; Cell Culture Techniques; Cell Size; Enzyme Inhibitors; Flavonoids; Ge | 2000 |
Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy.
Topics: Androstadienes; Animals; Antigens, CD; Cardiomegaly; Cell Size; Cells, Cultured; Cytokine Receptor g | 2000 |
MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Cells, Cultured; Enzy | 2001 |