pd 98059 has been researched along with Carcinoma in 30 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin, one of the main bioactive components extracted from a traditional Chinese medicinal herb, exhibits potent anticancer activity against many types of cancer cells including nasopharyngeal carcinoma (NPC)." | 7.80 | Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin. ( Hahn, SS; Tang, G; Tang, Q; Wu, J; Wu, Y; Zhao, S; Zheng, F, 2014) |
| " Wogonin, a flavonoid compound derived from the traditional Chinese medicine of Huang-Qin, has anticancer activity in many cancer cells including human nasopharyngeal carcinoma (NPC)." | 7.78 | Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. ( Chen, YW; Chow, SE; Huang, YK; Liang, CA; Wang, JS, 2012) |
| "Tamoxifen (Tam) is widely used in chemotherapy of breast cancer." | 7.74 | Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen. ( Härkönen, P; Kallio, A; Zheng, A, 2007) |
| "We previously reported that the PPARgamma agonist troglitazone (TRO) inhibits proliferation and induces apoptosis in human MCF-7 breast carcinoma cells." | 7.72 | Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. ( Blaschke, F; Bruemmer, D; Herle, AJ; Hsueh, WA; Law, RE; Yin, F, 2004) |
| "Curcumin, one of the main bioactive components extracted from a traditional Chinese medicinal herb, exhibits potent anticancer activity against many types of cancer cells including nasopharyngeal carcinoma (NPC)." | 3.80 | Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin. ( Hahn, SS; Tang, G; Tang, Q; Wu, J; Wu, Y; Zhao, S; Zheng, F, 2014) |
| " Wogonin, a flavonoid compound derived from the traditional Chinese medicine of Huang-Qin, has anticancer activity in many cancer cells including human nasopharyngeal carcinoma (NPC)." | 3.78 | Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. ( Chen, YW; Chow, SE; Huang, YK; Liang, CA; Wang, JS, 2012) |
| "Tamoxifen (Tam) is widely used in chemotherapy of breast cancer." | 3.74 | Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen. ( Härkönen, P; Kallio, A; Zheng, A, 2007) |
| "We previously reported that the PPARgamma agonist troglitazone (TRO) inhibits proliferation and induces apoptosis in human MCF-7 breast carcinoma cells." | 3.72 | Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. ( Blaschke, F; Bruemmer, D; Herle, AJ; Hsueh, WA; Law, RE; Yin, F, 2004) |
| " In addition to mitogenic ability, we demonstrate in this report that EGF protects a human esophageal carcinoma (CE) cell line, CE81T/VGH, from staurosporine-induced apoptosis." | 3.70 | Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. ( Chang, C; Hu, C; Leu, CM, 2000) |
| "Human cervical cancer cell lines C-33A and HeLa were transiently cotransfected with pSG5-HPV-16 E6 or 16 E7 constructs along with HIF-1 alpha small interfering RNA (siRNA) or nonspecific siRNA." | 1.34 | Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. ( Brown, J; Le, AD; Nishitani, J; Shi, S; Tang, X; Zhang, Q, 2007) |
| "To study the role of PKCdelta in thyroid cancer cells, we used a replication-deficient adenovirus (PKCdeltaAdV), to tightly control PKCdelta expression." | 1.33 | Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase. ( Fujii, T; Koike, K; Kuwano, M; Nakamura, AM; Shirouzu, K; Yamana, H; Yokoyama, G, 2006) |
| "The human breast carcinoma cell line MCF7 and its derivatives, MCF7/HER-2 and MDD2, were used in the study." | 1.31 | Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. ( Bacus, SS; Gudkov, AV; Keyomarsi, K; Komarov, AP; Lowe, M; Lyass, L; Seger, R; Yarden, Y; Yung, Y, 2001) |
| "Human colon cancer cells (Caco-2) were stimulated with increasing concentrations of sodium chloride (NaCl) or LPS." | 1.31 | Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer. ( Arbabi, S; Garcia, I; Jelacic, S; Maier, RV; Rosengart, MR, 2001) |
| "Exposure of MDA-MB-231 human mammary carcinoma cells to an ionizing radiation dose of 2 Gy results in immediate activation and Tyr phosphorylation of the epidermal growth factor receptor (EGFR)." | 1.30 | Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells. ( Amir, C; Contessa, JN; Dent, P; Mikkelsen, RB; Reardon, DB; Schmidt-Ullrich, RK; Valerie, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 20 (66.67) | 29.6817 |
| 2010's | 7 (23.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, Y | 1 |
| Lu, H | 1 |
| Yang, X | 1 |
| Song, W | 1 |
| Wu, J | 2 |
| Tang, Q | 1 |
| Zhao, S | 1 |
| Zheng, F | 1 |
| Wu, Y | 1 |
| Tang, G | 1 |
| Hahn, SS | 1 |
| Mühlen, S | 1 |
| Behren, A | 1 |
| Iftner, T | 1 |
| Plinkert, PK | 1 |
| Simon, C | 1 |
| Park, YS | 1 |
| Cho, NJ | 1 |
| Xu, LL | 1 |
| Mei, JH | 1 |
| Chen, JX | 1 |
| Xu, S | 1 |
| Qin, HY | 1 |
| Wang, SS | 1 |
| Habashy, HO | 1 |
| Powe, DG | 1 |
| Staka, CM | 1 |
| Rakha, EA | 1 |
| Ball, G | 1 |
| Green, AR | 1 |
| Aleskandarany, M | 1 |
| Paish, EC | 1 |
| Douglas Macmillan, R | 1 |
| Nicholson, RI | 1 |
| Ellis, IO | 1 |
| Gee, JM | 1 |
| Han, F | 1 |
| Zhu, HG | 1 |
| Puhr, M | 1 |
| Santer, FR | 1 |
| Neuwirt, H | 1 |
| Marcias, G | 1 |
| Hobisch, A | 1 |
| Culig, Z | 1 |
| McClaine, RJ | 1 |
| Marshall, AM | 1 |
| Wagh, PK | 1 |
| Waltz, SE | 1 |
| Liu, H | 1 |
| Duan, Z | 1 |
| Zheng, H | 1 |
| Hu, D | 1 |
| Li, M | 1 |
| Tao, Y | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Cao, Y | 1 |
| Chow, SE | 1 |
| Chen, YW | 1 |
| Liang, CA | 1 |
| Huang, YK | 1 |
| Wang, JS | 1 |
| Kobayashi, H | 1 |
| Suzuki, M | 1 |
| Kanayama, N | 1 |
| Nishida, T | 1 |
| Takigawa, M | 1 |
| Terao, T | 1 |
| Bondar, VM | 1 |
| Sweeney-Gotsch, B | 1 |
| Andreeff, M | 1 |
| Mills, GB | 1 |
| McConkey, DJ | 1 |
| Siddiqui, FA | 1 |
| Siddiqui, TF | 1 |
| Francis, JL | 1 |
| Jikuhara, A | 2 |
| Yoshii, M | 2 |
| Iwagaki, H | 2 |
| Mori, S | 2 |
| Nishibori, M | 2 |
| Tanaka, N | 2 |
| Yin, F | 1 |
| Bruemmer, D | 1 |
| Blaschke, F | 1 |
| Hsueh, WA | 1 |
| Law, RE | 1 |
| Herle, AJ | 1 |
| Rieger-Christ, KM | 1 |
| Lee, P | 1 |
| Zagha, R | 1 |
| Kosakowski, M | 1 |
| Moinzadeh, A | 1 |
| Stoffel, J | 1 |
| Ben-Ze'ev, A | 1 |
| Libertino, JA | 1 |
| Summerhayes, IC | 1 |
| Takahashi, HK | 1 |
| Kim, IA | 1 |
| Bae, SS | 1 |
| Fernandes, A | 1 |
| Muschel, RJ | 1 |
| McKenna, WG | 1 |
| Birnbaum, MJ | 1 |
| Bernhard, EJ | 1 |
| Koike, K | 1 |
| Fujii, T | 1 |
| Nakamura, AM | 1 |
| Yokoyama, G | 1 |
| Yamana, H | 1 |
| Kuwano, M | 1 |
| Shirouzu, K | 1 |
| Zheng, A | 1 |
| Kallio, A | 1 |
| Härkönen, P | 1 |
| Tang, X | 1 |
| Zhang, Q | 1 |
| Nishitani, J | 1 |
| Brown, J | 1 |
| Shi, S | 1 |
| Le, AD | 1 |
| Klemke, RL | 1 |
| Cai, S | 1 |
| Giannini, AL | 1 |
| Gallagher, PJ | 1 |
| de Lanerolle, P | 1 |
| Cheresh, DA | 1 |
| Reardon, DB | 1 |
| Contessa, JN | 1 |
| Mikkelsen, RB | 1 |
| Valerie, K | 1 |
| Amir, C | 1 |
| Dent, P | 1 |
| Schmidt-Ullrich, RK | 1 |
| Okajima, E | 1 |
| Thorgeirsson, UP | 1 |
| Leu, CM | 1 |
| Chang, C | 1 |
| Hu, C | 1 |
| Boucher, MJ | 1 |
| Morisset, J | 1 |
| Vachon, PH | 1 |
| Reed, JC | 1 |
| Lainé, J | 1 |
| Rivard, N | 1 |
| Yang, CP | 1 |
| Horwitz, SB | 1 |
| Bacus, SS | 1 |
| Gudkov, AV | 1 |
| Lowe, M | 1 |
| Lyass, L | 1 |
| Yung, Y | 1 |
| Komarov, AP | 1 |
| Keyomarsi, K | 1 |
| Yarden, Y | 1 |
| Seger, R | 1 |
| Arbabi, S | 1 |
| Rosengart, MR | 1 |
| Garcia, I | 1 |
| Jelacic, S | 1 |
| Maier, RV | 1 |
30 other studies available for pd 98059 and Carcinoma
| Article | Year |
|---|---|
BarH-like homeobox 1 induces the progression of cell malignant phenotype in endometrial carcinoma through the regulation of ERK/MEK signaling pathway.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Survival; Endometrial Neoplasms; Extracellular Sign | 2021 |
Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Re | 2014 |
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Topics: Animals; Anthracenes; Binding Sites; Carcinoma; Cell Line; Cell Line, Tumor; Cottontail rabbit papil | 2009 |
Enhanced proliferation of SNU-407 human colon cancer cells by muscarinic acetylcholine receptors.
Topics: Atropine; Carbachol; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Flavonoids; | 2008 |
[Study the role of PD98059 in ovarian carcinoma cell line HO-8910].
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma; Cell Cycle; Cell Line; Cell Line, Tumor; En | 2008 |
Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen.
Topics: Adult; Antigens, CD; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Carcinoma | 2010 |
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
Topics: Carcinoma; Caveolin 1; Cell Line, Tumor; Chromones; Epithelial Cells; Extracellular Signal-Regulated | 2010 |
SOCS-3 antagonises the proliferative and migratory effects of fibroblast growth factor-2 in prostate cancer by inhibition of p44/p42 MAPK signalling.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Fi | 2010 |
Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Surviv | 2010 |
EBV-encoded LMP1 upregulates Igκ 3'enhancer activity and Igκ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling.
Topics: Binding Sites; Carcinoma; Cell Line, Tumor; DNA Mutational Analysis; Enzyme Inhibitors; Extracellula | 2012 |
Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells.
Topics: Adenine; Apoptosis; Autophagy; Carcinoma; Cell Line, Tumor; Drugs, Chinese Herbal; Extracellular Sig | 2012 |
Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade.
Topics: Bone Neoplasms; Butadienes; Carcinoma; Chondrosarcoma; Depression, Chemical; Enzyme Activation; Enzy | 2002 |
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Topics: Androstadienes; Animals; Apoptosis; Carcinoma; Chromones; Collagen; Dose-Response Relationship, Drug | 2002 |
Hemoglobin induces the production and release of matrix metalloproteinase-9 from human malignant cells.
Topics: Carcinoma; Cycloheximide; Enzyme Inhibitors; Flavonoids; Genistein; Hemoglobins; Humans; Leukemia, M | 2003 |
MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2.
Topics: Calcium; Carcinoma; Cell Division; Colonic Neoplasms; Cytosol; Flavonoids; Humans; Immunoblotting; I | 2003 |
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Cell Cycle; Chromans; Enzyme Inhibito | 2004 |
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Co | 2004 |
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxyg | 2005 |
Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.
Topics: Animals; Carcinoma; Cell Survival; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Huma | 2005 |
Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase.
Topics: Adenoviridae; Breast Neoplasms; Carcinoma; Carcinoma, Papillary; Cell Cycle; Cell Line, Tumor; Cycli | 2006 |
Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen.
Topics: Breast Neoplasms; Carcinoma; Cell Death; Cell Line, Tumor; Cell Nucleus; ErbB Receptors; Estrogens; | 2007 |
Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.
Topics: Anticarcinogenic Agents; Carcinoma; Chromones; Female; Flavonoids; HeLa Cells; Humans; Hypoxia-Induc | 2007 |
Regulation of cell motility by mitogen-activated protein kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma; Cell Movement; Collagen; COS Cells | 1997 |
Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells.
Topics: Alkyl and Aryl Transferases; Apoptosis; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinas | 1999 |
Different regulation of vascular endothelial growth factor expression by the ERK and p38 kinase pathways in v-ras, v-raf, and v-myc transformed cells.
Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma; Cell Line; Cell | 2000 |
Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway.
Topics: Androstadienes; Apoptosis; Carcinoma; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, | 2000 |
MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells.
Topics: Apoptosis; bcl-X Protein; Carcinoma; Caspases; Cell Cycle; Cell Survival; Cysteine Endopeptidases; C | 2000 |
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antineoplastic Agents, | 2000 |
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Carcinoma; CDC2-CDC28 Kinas | 2001 |
Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer.
Topics: Carcinoma; Colonic Neoplasms; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2001 |