pd 98059 has been researched along with Carcinoma, Non-Small Cell Lung in 16 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperthermia is a promising treatment for human lung cancer, but recurrence of the primary lesion is common, as the residual tumor becomes adapted to heat treatment and growth is induced by hypoxia-triggered HIF-1a expression." | 1.43 | Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways. ( Wan, J; Wu, W, 2016) |
| "Methadone treatment suggests a novel therapeutic approach for patients presenting 'variant' SCLC and non-SCLC morphologies, since they respond less to conventional therapy." | 1.30 | Effects of bombesin on methadone-induced apoptosis of human lung cancer cells. ( Heusch, WL; Maneckjee, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, C | 1 |
| Tang, W | 1 |
| Fan, X | 1 |
| Wang, X | 1 |
| Wu, H | 1 |
| Xu, H | 1 |
| Xu, W | 1 |
| Gao, W | 1 |
| Wu, G | 1 |
| Toulany, M | 1 |
| Minjgee, M | 1 |
| Saki, M | 1 |
| Holler, M | 1 |
| Meier, F | 1 |
| Eicheler, W | 1 |
| Rodemann, HP | 1 |
| Zhao, S | 1 |
| Wu, J | 1 |
| Zheng, F | 1 |
| Tang, Q | 1 |
| Yang, L | 1 |
| Li, L | 1 |
| Wu, W | 2 |
| Hann, SS | 1 |
| Liu, F | 1 |
| Lin, B | 1 |
| Liu, X | 1 |
| Zhang, W | 1 |
| Zhang, E | 1 |
| Hu, L | 1 |
| Ma, Y | 1 |
| Li, X | 1 |
| Tang, X | 1 |
| Wan, J | 1 |
| Peter, Y | 1 |
| Comellas, A | 1 |
| Levantini, E | 1 |
| Ingenito, EP | 1 |
| Shapiro, SD | 1 |
| Guo, W | 1 |
| Wei, X | 1 |
| Wu, S | 1 |
| Wang, L | 1 |
| Peng, H | 1 |
| Wang, J | 1 |
| Fang, B | 1 |
| Lin, LC | 1 |
| Hsu, SL | 1 |
| Wu, CL | 1 |
| Liu, WC | 1 |
| Hsueh, CM | 1 |
| Han, S | 2 |
| Rivera, HN | 1 |
| Roman, J | 2 |
| Hurbin, A | 1 |
| Coll, JL | 1 |
| Dubrez-Daloz, L | 1 |
| Mari, B | 1 |
| Auberger, P | 1 |
| Brambilla, C | 1 |
| Favrot, MC | 1 |
| Lee, HY | 1 |
| Oh, SH | 1 |
| Suh, YA | 1 |
| Baek, JH | 1 |
| Papadimitrakopoulou, V | 1 |
| Huang, S | 1 |
| Hong, WK | 1 |
| Hemström, TH | 1 |
| Sandström, M | 1 |
| Zhivotovsky, B | 1 |
| Heusch, WL | 1 |
| Maneckjee, R | 1 |
| Ruhland, A | 1 |
| de Villiers, EM | 1 |
| Hirschowitz, E | 1 |
| Hidalgo, G | 1 |
| Doherty, D | 1 |
16 other studies available for pd 98059 and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Tra | 2018 |
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell | 2014 |
β-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1.
Topics: AMP-Activated Protein Kinases; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; | 2015 |
ERK Signaling Pathway Is Involved in HPV-16 E6 but not E7 Oncoprotein-Induced HIF-1α Protein Accumulation in NSCLC Cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Flavonoids; Gene Expression Regulation, Neoplastic | 2016 |
Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways.
Topics: Androstadienes; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell | 2016 |
Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization.
Topics: Base Sequence; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; C | 2009 |
Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; D | 2010 |
Peroxisome proliferator-activated receptor γ (PPARγ) plays a critical role in the development of TGFβ resistance of H460 cell.
Topics: Anilides; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor | 2011 |
Peroxisome proliferator-activated receptor-gamma ligands inhibit alpha5 integrin gene transcription in non-small cell lung carcinoma cells.
Topics: Base Sequence; Benzophenones; Binding Sites; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA, | 2005 |
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
Topics: Amphiregulin; Androstadienes; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; C | 2005 |
Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer.
Topics: Adenoviridae; Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspase 3; Casp | 2005 |
COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals.
Topics: Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase Inhibitors; Flavonoids; | 2006 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell S | 2006 |
Effects of bombesin on methadone-induced apoptosis of human lung cancer cells.
Topics: Apoptosis; Blotting, Western; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Non | 1999 |
Opposite regulation of the HPV 20-URR and HPV 27-URR promoters by ultraviolet irradiation and cytokines.
Topics: Androstadienes; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Chloramphenicol O-Acetyltransfera | 2001 |
Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with DeltaE1, DeltaE3 recombinant adenovirus vectors.
Topics: Adenoviridae; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Fla | 2002 |