pd 98059 has been researched along with Carcinoma, Epidermoid in 27 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in esophageal squamous cell carcinoma xenografts in nude mice." | 3.83 | [Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice]. ( Ding, Y; Liu, XJ; Liu, YP; Wang, XL; Yang, HC; Yue, M, 2016) |
| "In this study we have investigated the role of mitogen-induced and stress-activated MAP kinase pathways in the cellular response to taxol, etoposide and ceramide in three different human cancer cell lines: HeLa cervical carcinoma, MCF7 breast cancer and A431 squamous carcinoma cells." | 3.71 | The role of MAPK pathways in the action of chemotherapeutic drugs. ( Boldt, S; Kolch, W; Weidle, UH, 2002) |
| "Using UT-SCC5 and SAS head and neck cancer cells we established a differential phosphoproteomic approach for quantitative analysis of DNA repair proteins by stable isotope labeling with amino acids." | 1.42 | Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1. ( Dikomey, E; Gleißner, L; Hoffer, K; Kriegs, M; Kwiatkowski, M; Myllynen, L; Petersen, C; Riepen, B; Rothkamm, K; Schlüter, H; Wurlitzer, M, 2015) |
| "Oral squamous cell carcinoma (OSCC) has a striking tendency to migrate and metastasize." | 1.38 | Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells. ( Chiang, IP; Chuang, JY; Lai, CH; Lin, CD; Tang, CH; Yu, NY, 2012) |
| "Arecoline was found to elevate HSP27 expression in a dose- and time-dependent manner (P < 0." | 1.38 | Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yu, CC, 2012) |
| "Stimulation of HNSCC cells with EGF caused a significant increase in migration (p < 0." | 1.37 | Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways. ( Arnold, W; Beck, C; Boulesteix, AL; Knopf, A; Margraf, J; Pickhard, AC; Pigorsch, S; Piontek, G; Reiter, R; Scherer, EQ; Schlegel, J; Stark, T, 2011) |
| "Arecoline was found to elevate HIF-1α expression in a dose- and time-dependent manner (P<0." | 1.36 | Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yang, SF, 2010) |
| "Arecoline was found to elevate HSP70 expression in a dose- and time-dependent manner (p<0." | 1.35 | The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH, 2008) |
| " This was to study the signal transduction pathways that might exert the apoptotic effects of bleomycin A5 on tumor cells, as well as to examine the possibility of lower dosing of such drug in combinative treatment with other compounds in vitro." | 1.32 | MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. ( Chou, MY; Tai, KW; Yang, JJ; Yang, LC; Yang, SH, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 13 (48.15) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, W | 1 |
| Zhang, B | 1 |
| Ding, F | 1 |
| Zhang, W | 1 |
| Sun, B | 1 |
| Liu, Z | 1 |
| Toulany, M | 1 |
| Minjgee, M | 1 |
| Saki, M | 1 |
| Holler, M | 1 |
| Meier, F | 1 |
| Eicheler, W | 1 |
| Rodemann, HP | 1 |
| Huang, L | 1 |
| Chen, C | 1 |
| Zhang, G | 1 |
| Ju, Y | 1 |
| Zhang, J | 1 |
| Wang, H | 1 |
| Li, J | 1 |
| Myllynen, L | 1 |
| Kwiatkowski, M | 1 |
| Gleißner, L | 1 |
| Riepen, B | 1 |
| Hoffer, K | 1 |
| Wurlitzer, M | 1 |
| Petersen, C | 1 |
| Dikomey, E | 1 |
| Rothkamm, K | 1 |
| Schlüter, H | 1 |
| Kriegs, M | 1 |
| Yue, M | 1 |
| Liu, XJ | 1 |
| Ding, Y | 1 |
| Wang, XL | 1 |
| Yang, HC | 1 |
| Liu, YP | 1 |
| Singh, R | 1 |
| Lei, P | 1 |
| Andreadis, ST | 1 |
| Zhang, X | 1 |
| Makino, T | 1 |
| Muchemwa, FC | 1 |
| Lin, T | 1 |
| Wakasugi, S | 1 |
| Egawa, K | 1 |
| Ihn, H | 1 |
| Lu, J | 1 |
| Zhao, J | 2 |
| Liu, K | 1 |
| Yang, H | 1 |
| Huang, Y | 1 |
| Qin, Z | 1 |
| Bai, R | 1 |
| Li, P | 1 |
| Ma, J | 1 |
| Yan, W | 1 |
| Zhao, M | 1 |
| Dong, Z | 1 |
| Lee, SS | 3 |
| Tsai, CH | 3 |
| Yang, SF | 1 |
| Ho, YC | 3 |
| Chang, YC | 3 |
| Pickhard, AC | 1 |
| Margraf, J | 1 |
| Knopf, A | 1 |
| Stark, T | 1 |
| Piontek, G | 1 |
| Beck, C | 1 |
| Boulesteix, AL | 1 |
| Scherer, EQ | 1 |
| Pigorsch, S | 1 |
| Schlegel, J | 1 |
| Arnold, W | 1 |
| Reiter, R | 1 |
| Chuang, JY | 1 |
| Yu, NY | 1 |
| Chiang, IP | 1 |
| Lai, CH | 1 |
| Lin, CD | 1 |
| Tang, CH | 1 |
| Yu, CC | 1 |
| Kim, YN | 1 |
| Dam, P | 1 |
| Bertics, PJ | 1 |
| Boldt, S | 1 |
| Weidle, UH | 1 |
| Kolch, W | 1 |
| Yang, LC | 1 |
| Yang, SH | 1 |
| Tai, KW | 1 |
| Chou, MY | 1 |
| Yang, JJ | 1 |
| Shen, SC | 1 |
| Ko, CH | 1 |
| Hsu, KC | 1 |
| Chen, YC | 1 |
| Kim, CH | 1 |
| Song, KS | 1 |
| Kim, KS | 1 |
| Kim, JY | 1 |
| Lee, BJ | 1 |
| Lee, JG | 1 |
| Yoon, JH | 1 |
| Crowe, DL | 1 |
| Nguyen, DC | 1 |
| Ohannessian, A | 1 |
| Lamm, W | 1 |
| Vormittag, L | 1 |
| Turhani, D | 1 |
| Erovic, BM | 1 |
| Czembirek, C | 1 |
| Eder-Czembirek, C | 1 |
| Thurnher, D | 1 |
| Kim, AL | 1 |
| Zhu, Y | 1 |
| Zhu, H | 1 |
| Han, L | 1 |
| Kopelovich, L | 1 |
| Bickers, DR | 1 |
| Athar, M | 1 |
| Sah, NK | 1 |
| Munshi, A | 1 |
| Hobbs, M | 1 |
| Carter, BZ | 1 |
| Andreeff, M | 1 |
| Meyn, RE | 1 |
| Simon, C | 2 |
| Juarez, J | 1 |
| Nicolson, GL | 1 |
| Boyd, D | 2 |
| Goepfert, H | 1 |
| Carter, S | 1 |
| Auer, KL | 1 |
| Reardon, DB | 1 |
| Birrer, M | 1 |
| Fisher, PB | 1 |
| Valerie, K | 1 |
| Schmidt-Ullrich, R | 1 |
| Mikkelsen, R | 1 |
| Dent, P | 1 |
| Matsuura, H | 1 |
| Sakaue, M | 1 |
| Subbaramaiah, K | 1 |
| Kamitani, H | 1 |
| Eling, TE | 1 |
| Dannenberg, AJ | 1 |
| Tanabe, T | 1 |
| Inoue, H | 1 |
| Arata, J | 1 |
| Jetten, AM | 1 |
| Perrais, M | 1 |
| Pigny, P | 1 |
| Copin, MC | 1 |
| Aubert, JP | 1 |
| Van Seuningen, I | 1 |
27 other studies available for pd 98059 and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Expression of SLP-2 was associated with invasion of esophageal squamous cell carcinoma.
Topics: Blood Proteins; Blotting, Western; Butadienes; Carcinoma, Squamous Cell; Esophageal Neoplasms; Flavo | 2013 |
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell | 2014 |
STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Flavonoids; Gene Expressi | 2015 |
Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1.
Topics: Carcinoma, Squamous Cell; DNA; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Enzyme | 2015 |
[Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice].
Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2016 |
PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering.
Topics: Amino Acid Substitution; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamou | 2009 |
Activation of the extracellular signal-regulated kinases signaling pathway in squamous cell carcinoma of the skin.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP K | 2007 |
MAPK/ERK1/2 signaling mediates endothelial-like differentiation of immature DCs in the microenvironment of esophageal squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Dendrit | 2010 |
Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; C | 2010 |
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Radiation; Ep | 2011 |
Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells.
Topics: Antibodies, Monoclonal; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cyste | 2012 |
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Catechin; Cyclooxy | 2012 |
Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.
Topics: Androstadienes; Carcinoma, Squamous Cell; Caveolae; Caveolin 1; Caveolins; Cell Line; Chromones; Col | 2002 |
The role of MAPK pathways in the action of chemotherapeutic drugs.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Squamous Cell; Cell C | 2002 |
MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities.
Topics: Antibiotics, Antineoplastic; Apoptosis; Bleomycin; Calcium-Calmodulin-Dependent Protein Kinases; Car | 2004 |
3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E2 production.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; Cell Division; Colony-Forming Uni | 2004 |
Sulindac sulfide-induced apoptosis in sinonasal cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinoma, Squa | 2005 |
Mechanism of telomerase repression during terminal differentiation of normal epithelial cells and squamous carcinoma lines.
Topics: Binding Sites; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous | 2005 |
The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines.
Topics: Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Line | 2005 |
Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways.
Topics: Antineoplastic Agents, Phytogenic; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Cyc | 2006 |
Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells.
Topics: Carcinoma, Squamous Cell; CDC2 Protein Kinase; Cell Line, Tumor; Down-Regulation; Flavonoids; Genes, | 2006 |
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Adult; Aged; Antineoplastic Agents; Areca; Arecoline; Blotting, Western; Carcinoma, Squamous Cell; C | 2008 |
Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion.
Topics: Carcinoma, Squamous Cell; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulatio | 1996 |
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Collagenases; Enzyme Activat | 1998 |
Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell De | 1998 |
Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases.
Topics: Amphiregulin; Carcinoma, Squamous Cell; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; EGF Family | 1999 |
Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1.
Topics: Base Sequence; Carcinoma, Squamous Cell; DNA Primers; Enzyme Inhibitors; Epidermal Growth Factor; Er | 2002 |