pd 98059 has been researched along with Cancer of Prostate in 39 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "EMT in prostate cancer induced by FGF8b can be mediated by ERK kinase pathway, in which mitogen-activated/extraceluer signal regulated kinase 1 (MEK1) may be a key factor." | 1.38 | [Molecular mechanism of FGF8b regulation of epithelial-mesenchymal transition in prostate cancer cells]. ( Fan, B; Li, Z; Liu, H; Qi, F; Wang, G, 2012) |
| "Since prostate cancer gradually progresses to an androgen-independent state despite the stress caused by various therapeutic agents, we hypothesized the stress-activated protein kinases (SAPKs) involvement in androgen-independent growth or IL-6 secretion of prostate cancer cells." | 1.34 | p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. ( Hakariya, T; Igawa, T; Kanetake, H; Sakai, H; Shida, Y, 2007) |
| "ATP stimulated prostate cancer cell invasion." | 1.33 | [ERK1/2 and p38 kinases are important regulators in P2Y receptor-mediated prostate cancer invasion]. ( Chen, L; Fang, WG; He, HY; Heng, WJ; Li, HM; Li, Y; You, JF, 2005) |
| " The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors." | 1.32 | Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells. ( Cohen, P; Francis, MJ; Moore, MG; Peehl, DM; Wetterau, LA, 2003) |
| "Radiation-induced Fas sensitization in prostate cancer cell was mediated through p53-dependent transactivation of the Fas gene, which can be blocked by androgen stimulation mainly through induction of c-jun." | 1.32 | Androgen and the blocking of radiation-induced sensitization to Fas-mediated apoptosis through c-jun induction in prostate cancer cells. ( Ishida, E; Kishi, M; Konishi, N; Nakamura, M; Shimada, K, 2003) |
| " In those cells in the presence of PD98059, the ERK activation and NSE elevation were abolished, following a dose-response fashion." | 1.32 | Receptor protein tyrosine phosphatase alpha signaling is involved in androgen depletion-induced neuroendocrine differentiation of androgen-sensitive LNCaP human prostate cancer cells. ( Hansen, J; Kondrikov, D; Lin, FF; Lin, MF; Yuan, TC; Zhang, XQ, 2003) |
| "Addition of PGE(2) to PC-3ML human prostate cancer cells had no effect on HIF-1alpha mRNA levels." | 1.31 | Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line. ( Dosoretz, A; Holland, JF; Kirschenbaum, A; Levine, AC; Liu, XH; Lu, M; Yao, S, 2002) |
| "We reported previously that human prostate cancer cell line TSU-Pr1 can differentiate into microglia-like cells by 12-O-tetra-decanoylphorbol-13-acetate (TPA) treatment." | 1.31 | Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1. ( Hamada, H; Shimizu, T; Sugibayashi, R; Suzuki, T; Takeda, K; Yamamoto, N, 2001) |
| "Interleukin-6 (IL-6) induces prostate cancer (CaP) cell proliferation in vitro." | 1.31 | Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression. ( Keller, ET; Lin, DL; Whitney, MC; Yao, Z, 2001) |
| "Here we demonstrate that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2/Neu." | 1.30 | From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. ( Chang, C; Kang, HY; Lin, HK; Lin, MF; Thin, TH; Yeh, S, 1999) |
| "Treatment of androgen responsive prostate cancer cells with dihydrotestosterone leads to a rapid and reversible activation of mitogen-activated protein kinases MAPKs (also called extracellular signal-regulated kinases or Erks)." | 1.30 | Rapid signalling by androgen receptor in prostate cancer cells. ( Becker, M; Cato, AC; Klocker, H; Mink, S; Peterziel, H; Schonert, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (7.69) | 18.2507 |
| 2000's | 30 (76.92) | 29.6817 |
| 2010's | 6 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Zhu, G | 1 |
| Getzenberg, RH | 1 |
| Veltri, RW | 1 |
| Davis, JE | 1 |
| Xie, X | 1 |
| Guo, J | 1 |
| Huang, W | 1 |
| Chu, WM | 1 |
| Huang, S | 1 |
| Teng, Y | 1 |
| Wu, G | 1 |
| Tian, H | 1 |
| Zhou, Y | 1 |
| Yang, G | 1 |
| Geng, Y | 1 |
| Wu, S | 1 |
| Hu, Y | 1 |
| Lin, K | 1 |
| Wu, W | 1 |
| Zhang, L | 2 |
| Davis, JS | 1 |
| Zelivianski, S | 2 |
| Lin, FF | 2 |
| Schutte, R | 1 |
| Davis, TL | 2 |
| Hauke, R | 2 |
| Batra, SK | 1 |
| Lin, MF | 4 |
| Chan, QK | 1 |
| Lam, HM | 1 |
| Ng, CF | 1 |
| Lee, AY | 1 |
| Chan, ES | 1 |
| Ng, HK | 1 |
| Ho, SM | 1 |
| Lau, KM | 1 |
| Puhr, M | 1 |
| Santer, FR | 1 |
| Neuwirt, H | 2 |
| Marcias, G | 1 |
| Hobisch, A | 3 |
| Culig, Z | 3 |
| Fan, B | 1 |
| Wang, G | 1 |
| Qi, F | 1 |
| Li, Z | 1 |
| Liu, H | 1 |
| Godoy-Tundidor, S | 1 |
| Pfeil, K | 1 |
| Bartsch, G | 1 |
| Liu, XH | 1 |
| Kirschenbaum, A | 1 |
| Lu, M | 1 |
| Yao, S | 1 |
| Dosoretz, A | 1 |
| Holland, JF | 1 |
| Levine, AC | 1 |
| Tyagi, A | 1 |
| Agarwal, R | 1 |
| Agarwal, C | 1 |
| Shimada, K | 3 |
| Nakamura, M | 3 |
| Ishida, E | 3 |
| Kishi, M | 3 |
| Konishi, N | 3 |
| Yacoub, A | 1 |
| McKinstry, R | 1 |
| Hinman, D | 1 |
| Chung, T | 1 |
| Dent, P | 1 |
| Hagan, MP | 1 |
| Moore, MG | 1 |
| Wetterau, LA | 1 |
| Francis, MJ | 1 |
| Peehl, DM | 1 |
| Cohen, P | 1 |
| Chieffi, P | 1 |
| Kisslinger, A | 1 |
| Sinisi, AA | 1 |
| Abbondanza, C | 1 |
| Tramontano, D | 1 |
| Spellman, M | 1 |
| Kellerman, M | 1 |
| Kakitelashvilli, V | 1 |
| Zhou, XW | 1 |
| Lugo, E | 1 |
| Lee, MS | 1 |
| Taylor, R | 1 |
| Zhang, XQ | 1 |
| Kondrikov, D | 1 |
| Yuan, TC | 1 |
| Hansen, J | 1 |
| Matsuyoshi, S | 1 |
| Chen, L | 1 |
| He, HY | 1 |
| Li, HM | 1 |
| You, JF | 1 |
| Heng, WJ | 1 |
| Li, Y | 1 |
| Fang, WG | 1 |
| Kim, BY | 1 |
| Kim, KA | 1 |
| Kwon, O | 1 |
| Kim, SO | 1 |
| Kim, MS | 1 |
| Kim, BS | 1 |
| Oh, WK | 1 |
| Kim, GD | 1 |
| Jung, M | 1 |
| Ahn, JS | 1 |
| Annabi, B | 1 |
| Bouzeghrane, M | 1 |
| Currie, JC | 1 |
| Dulude, H | 1 |
| Daigneault, L | 1 |
| Garde, S | 1 |
| Rabbani, SA | 1 |
| Panchal, C | 1 |
| Wu, JJ | 1 |
| Béliveau, R | 1 |
| Suthiphongchai, T | 1 |
| Phimsen, S | 1 |
| Sakulkhu, U | 1 |
| Tohtong, R | 1 |
| Ricote, M | 1 |
| García-Tuñón, I | 1 |
| Fraile, B | 1 |
| Fernández, C | 1 |
| Aller, P | 1 |
| Paniagua, R | 1 |
| Royuela, M | 1 |
| Cavarretta, IT | 1 |
| Untergasser, G | 1 |
| Moser, PL | 1 |
| Zaki, MH | 1 |
| Steiner, H | 1 |
| Rumpold, H | 1 |
| Fuchs, D | 1 |
| Nemeth, JA | 1 |
| Chen, HJ | 1 |
| Wang, H | 1 |
| Wang, QY | 1 |
| Wang, GM | 1 |
| Takahashi, Y | 1 |
| Perkins, SN | 1 |
| Hursting, SD | 1 |
| Wang, TT | 2 |
| Shida, Y | 1 |
| Igawa, T | 1 |
| Hakariya, T | 1 |
| Sakai, H | 1 |
| Kanetake, H | 1 |
| Trasino, SE | 1 |
| Harrison, EH | 1 |
| Albrecht, DS | 1 |
| Clubbs, EA | 1 |
| Ferruzzi, M | 1 |
| Bomser, JA | 1 |
| Zhang, YX | 1 |
| Kong, CZ | 1 |
| Chang, NS | 1 |
| Yeh, S | 1 |
| Lin, HK | 1 |
| Kang, HY | 1 |
| Thin, TH | 1 |
| Chang, C | 1 |
| Peterziel, H | 1 |
| Mink, S | 1 |
| Schonert, A | 1 |
| Becker, M | 1 |
| Klocker, H | 1 |
| Cato, AC | 1 |
| Guo, C | 1 |
| Luttrell, LM | 1 |
| Price, DT | 1 |
| Park, BJ | 1 |
| Park, JI | 1 |
| Byun, DS | 1 |
| Park, JH | 1 |
| Chi, SG | 1 |
| Velasco, L | 1 |
| Ruiz, L | 1 |
| Sánchez, MG | 1 |
| Díaz-Laviada, I | 1 |
| Sugibayashi, R | 1 |
| Shimizu, T | 1 |
| Suzuki, T | 1 |
| Yamamoto, N | 1 |
| Hamada, H | 1 |
| Takeda, K | 1 |
| Lin, DL | 1 |
| Whitney, MC | 1 |
| Yao, Z | 1 |
| Keller, ET | 1 |
| Sauer, H | 1 |
| Klimm, B | 1 |
| Hescheler, J | 1 |
| Wartenberg, M | 1 |
39 other studies available for pd 98059 and Cancer of Prostate
| Article | Year |
|---|---|
The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Targeting Drugs in Prostate Cancer.
Topics: Cell Line, Tumor; Cell Survival; Chromones; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fl | 2015 |
ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling.
Topics: ADP-Ribosylation Factor 1; Animals; Butadienes; Carcinogenesis; Cell Line, Tumor; Cell Proliferation | 2016 |
Sulforaphane-cysteine suppresses invasion via downregulation of galectin-1 in human prostate cancer DU145 and PC3 cells.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine; Down-Regulat | 2016 |
Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment.
Topics: Androgens; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosi | 2009 |
Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cycl | 2010 |
SOCS-3 antagonises the proliferative and migratory effects of fibroblast growth factor-2 in prostate cancer by inhibition of p44/p42 MAPK signalling.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Fi | 2010 |
[Molecular mechanism of FGF8b regulation of epithelial-mesenchymal transition in prostate cancer cells].
Topics: Epithelial-Mesenchymal Transition; Fibroblast Growth Factor 8; Flavonoids; Humans; Male; MAP Kinase | 2012 |
Acquisition of agonistic properties of nonsteroidal antiandrogens after treatment with oncostatin M in prostate cancer cells.
Topics: Androgen Antagonists; Anilides; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; | 2002 |
Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.
Topics: Active Transport, Cell Nucleus; Arachidonic Acid; Catalysis; Cell Nucleus; Culture Media, Serum-Free | 2002 |
Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenocarcinoma; Anthrac | 2003 |
Requirement of c-jun for testosterone-induced sensitization to N-(4-hydroxyphenyl)retinamide-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Enzyme Inhibitors; Fenretinide; Flavonoids; Humans; JNK Mitogen-Ac | 2003 |
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
Topics: Adenocarcinoma; Autocrine Communication; Cobalt Radioisotopes; DNA Damage; DNA Repair; DNA-Binding P | 2003 |
Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.
Topics: Androstadienes; Cell Division; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme I | 2003 |
17beta-estradiol-induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor alpha-Src complex in human prostate cells.
Topics: Blotting, Western; Cell Division; Cell Line; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; | 2003 |
Androgen and the blocking of radiation-induced sensitization to Fas-mediated apoptosis through c-jun induction in prostate cancer cells.
Topics: Androgens; Apoptosis; Cell Survival; Chromatin; Cosmids; Dihydrotestosterone; DNA Fragmentation; Dos | 2003 |
ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells.
Topics: Apoptosis; bcl-X Protein; Butadienes; Docetaxel; Drug Synergism; Enzyme Inhibitors; Flavonoids; Huma | 2003 |
Receptor protein tyrosine phosphatase alpha signaling is involved in androgen depletion-induced neuroendocrine differentiation of androgen-sensitive LNCaP human prostate cancer cells.
Topics: Androgens; Blotting, Western; Cell Differentiation; Cell Division; DNA, Complementary; Electrophores | 2003 |
The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells.
Topics: 2-Methoxyestradiol; Apoptosis; Arabidopsis Proteins; Carrier Proteins; CASP8 and FADD-Like Apoptosis | 2004 |
[ERK1/2 and p38 kinases are important regulators in P2Y receptor-mediated prostate cancer invasion].
Topics: Cell Line, Tumor; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Male; Mitogen-Activated Protein | 2005 |
NF-kappaB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation.
Topics: Apoptosis; Cell Line, Transformed; Cell Line, Tumor; Chromones; Dose-Response Relationship, Radiatio | 2005 |
Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling.
Topics: Antigens, Surface; Bone Neoplasms; Cell Line, Tumor; ELAV Proteins; ELAV-Like Protein 1; Flavonoids; | 2006 |
PD98059-inhibited invasion of Dunning rat prostate cancer cells involves suppression of motility but not MMP-2 or uPA secretion.
Topics: Adenocarcinoma; Animals; Cell Adhesion; Cell Line, Tumor; Cell Movement; Extracellular Matrix; Extra | 2006 |
P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells.
Topics: Anthracenes; Apoptosis; Blotting, Western; Cell Line, Tumor; Dose-Response Relationship, Drug; Extra | 2006 |
The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1.
Topics: Antibodies, Monoclonal; Apoptosis; Autocrine Communication; Disease Progression; Flavonoids; Gene Ex | 2007 |
[Effect of epidermal growth factor signal pathway on integrin alpha5 beta1 in prostate cancer cell line DU145].
Topics: Cell Adhesion; Cell Line, Tumor; Epidermal Growth Factor; Flavonoids; Humans; Integrin alpha5beta1; | 2006 |
17beta-Estradiol differentially regulates androgen-responsive genes through estrogen receptor-beta- and extracellular-signal regulated kinase-dependent pathways in LNCaP human prostate cancer cells.
Topics: Androgens; Base Sequence; Cell Line, Tumor; DNA Primers; Estradiol; Estrogen Receptor beta; Extracel | 2007 |
p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion.
Topics: Androgens; Anthracenes; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Extracellular Signa | 2007 |
Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP.
Topics: Aldehyde Dehydrogenase; Androgens; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; C | 2007 |
Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation.
Topics: Anticarcinogenic Agents; Catechin; Cell Line; Cell Line, Tumor; Cell Proliferation; Chromones; Enzym | 2008 |
[The role of mitogen-activated protein kinase cascades in inhibition of proliferation in human prostate carcinoma cells by raloxifene: an in vitro experiment].
Topics: Apoptosis; Blotting, Western; Bone Density Conservation Agents; Caspase 3; Cell Cycle; Cell Line, Tu | 2008 |
Hyaluronidase enhancement of TNF-mediated cell death is reversed by TGF-beta 1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases | 1997 |
From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.
Topics: Androgen Antagonists; Androgens; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Flavon | 1999 |
Rapid signalling by androgen receptor in prostate cancer cells.
Topics: Adenocarcinoma; Androgen Antagonists; Cell Nucleus; Cytoplasm; Dihydrotestosterone; DNA-Binding Prot | 1999 |
Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.
Topics: Cell Division; Dihydrotestosterone; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; | 2000 |
Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer.
Topics: Cell Cycle; Cell Division; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; F | 2000 |
delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1.
Topics: Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Huma | 2001 |
Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.
Topics: Adenoviridae; Blotting, Northern; Blotting, Western; Carcinogens; Cell Differentiation; Cyclin-Depen | 2001 |
Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.
Topics: Anilides; Blotting, Western; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flav | 2001 |
Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP.
Topics: Acetylcysteine; Adenosine Triphosphate; Calcium; Cell Division; Dose-Response Relationship, Drug; En | 2001 |