Page last updated: 2024-11-02

pd 98059 and Cancer of Mouth

pd 98059 has been researched along with Cancer of Mouth in 11 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Research Excerpts

ExcerptRelevanceReference
"Licochalcone A (Lico-A) is a natural phenol licorice compound with multiple bioactivities, including anti-inflammatory, anti-microbial, anti-fungal and osteogenesis-inducing properties."1.40Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway. ( Cho, SS; Im, HJ; Kim, CS; Kim, DK; Kim, JS; Kim, SG; Lee, SY; Moon, SM; Oh, JS; Park, MR; Yoon, G; You, JS, 2014)
"Oral squamous cell carcinoma (OSCC) has a striking tendency to migrate and metastasize."1.38Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells. ( Chiang, IP; Chuang, JY; Lai, CH; Lin, CD; Tang, CH; Yu, NY, 2012)
"Arecoline was found to elevate HSP27 expression in a dose- and time-dependent manner (P < 0."1.38Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yu, CC, 2012)
"Arecoline was found to elevate HIF-1α expression in a dose- and time-dependent manner (P<0."1.36Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yang, SF, 2010)
"Oral cancer is a prevalent type of cancer in Asian countries."1.35S-allylcysteine modulates the expression of E-cadherin and inhibits the malignant progression of human oral cancer. ( Chiang, EP; Chung, JG; Hsu, CY; Lee, HZ; Tang, FY, 2009)
"Arecoline was found to elevate HSP70 expression in a dose- and time-dependent manner (p<0."1.35The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas. ( Chang, YC; Ho, YC; Lee, SS; Tsai, CH, 2008)
" This was to study the signal transduction pathways that might exert the apoptotic effects of bleomycin A5 on tumor cells, as well as to examine the possibility of lower dosing of such drug in combinative treatment with other compounds in vitro."1.32MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. ( Chou, MY; Tai, KW; Yang, JJ; Yang, LC; Yang, SH, 2004)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (36.36)29.6817
2010's7 (63.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yu, HJ1
Shin, JA1
Lee, SO1
Kwon, KH1
Cho, SD1
Kim, JS1
Park, MR1
Lee, SY1
Kim, DK1
Moon, SM1
Kim, CS1
Cho, SS1
Yoon, G1
Im, HJ1
You, JS1
Oh, JS1
Kim, SG1
Ko, SY1
Ko, HA1
Shieh, TM1
Chang, WC1
Chen, HI1
Chang, SS1
Lin, IH1
Tang, FY1
Chiang, EP1
Chung, JG1
Lee, HZ1
Hsu, CY1
Lee, SS3
Tsai, CH3
Yang, SF1
Ho, YC3
Chang, YC3
Chuang, JY1
Yu, NY1
Chiang, IP1
Lai, CH1
Lin, CD1
Tang, CH1
Yu, CC1
Yang, SH2
Liao, PH1
Pan, YF1
Chen, SL1
Chou, SS1
Chou, MY2
Yang, LC1
Tai, KW1
Yang, JJ1
Lee, SK2
Jang, HJ1
Lee, HJ1
Lee, J1
Jeon, BH1
Jun, CD1
Kim, EC1

Other Studies

11 other studies available for pd 98059 and Cancer of Mouth

ArticleYear
Extracellular signal‑regulated kinase inhibition is required for methanol extract of Smilax china L.‑induced apoptosis through death receptor 5 in human oral mucoepidermoid carcinoma cells.
    Molecular medicine reports, 2014, Volume: 9, Issue:2

    Topics: Apoptosis; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases;

2014
Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway.
    Oncology reports, 2014, Volume: 31, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 3; Caspase 8; Caspase Inhibitors; Cell Line, Tum

2014
Cell migration is regulated by AGE-RAGE interaction in human oral cancer cells in vitro.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Adult; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diabetes Complications; Diabetes Mellitu

2014
S-allylcysteine modulates the expression of E-cadherin and inhibits the malignant progression of human oral cancer.
    The Journal of nutritional biochemistry, 2009, Volume: 20, Issue:12

    Topics: Adherens Junctions; Cadherins; Cell Proliferation; Cysteine; Disease Progression; Enzyme Activation;

2009
Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.
    Oral diseases, 2010, Volume: 16, Issue:7

    Topics: Acetylcysteine; Areca; Arecoline; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; C

2010
Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells.
    Journal of cellular biochemistry, 2012, Volume: 113, Issue:6

    Topics: Antibodies, Monoclonal; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cyste

2012
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
    Oral diseases, 2012, Volume: 18, Issue:7

    Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Catechin; Cyclooxy

2012
The novel p53-dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells.
    Phytotherapy research : PTR, 2013, Volume: 27, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apigenin; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles;

2013
MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2004, Volume: 33, Issue:1

    Topics: Antibiotics, Antineoplastic; Apoptosis; Bleomycin; Calcium-Calmodulin-Dependent Protein Kinases; Car

2004
p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.
    Life sciences, 2006, Sep-05, Volume: 79, Issue:15

    Topics: Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Differentiation; Cell Proliferation; Cytochromes c;

2006
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
    Oral oncology, 2008, Volume: 44, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Areca; Arecoline; Blotting, Western; Carcinoma, Squamous Cell; C

2008