pd 98059 has been researched along with Cancer of Esophagus in 7 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in esophageal squamous cell carcinoma xenografts in nude mice." | 3.83 | [Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice]. ( Ding, Y; Liu, XJ; Liu, YP; Wang, XL; Yang, HC; Yue, M, 2016) |
| " In addition to mitogenic ability, we demonstrate in this report that EGF protects a human esophageal carcinoma (CE) cell line, CE81T/VGH, from staurosporine-induced apoptosis." | 3.70 | Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. ( Chang, C; Hu, C; Leu, CM, 2000) |
| "A panel of gastric and esophageal cancer cell lines was treated with wortmannin as an Akt-signal inhibitor; the MAPK signal inhibitor PD98059; lapatinib, which inhibits both the epidermal growth factor receptor and HER2 tyrosine kinase; or siRNA for MAPK." | 1.39 | The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. ( Fujii, H; Izawa, S; Kiessling, R; Kono, K; Kua, LF; Mimura, K; Mueller, A; Seliger, B; Shiraishi, K; So, J; Yong, WP, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, D | 1 |
| Liu, Y | 1 |
| Qi, B | 1 |
| Gu, C | 1 |
| Huo, S | 1 |
| Zhao, B | 1 |
| Cao, W | 3 |
| Zhang, B | 1 |
| Ding, F | 1 |
| Zhang, W | 1 |
| Sun, B | 1 |
| Liu, Z | 1 |
| Mimura, K | 1 |
| Shiraishi, K | 1 |
| Mueller, A | 1 |
| Izawa, S | 1 |
| Kua, LF | 1 |
| So, J | 1 |
| Yong, WP | 1 |
| Fujii, H | 1 |
| Seliger, B | 1 |
| Kiessling, R | 1 |
| Kono, K | 1 |
| Yue, M | 1 |
| Liu, XJ | 1 |
| Ding, Y | 1 |
| Wang, XL | 1 |
| Yang, HC | 1 |
| Liu, YP | 1 |
| Zhou, X | 1 |
| Li, D | 1 |
| Resnick, MB | 1 |
| Behar, J | 2 |
| Wands, J | 2 |
| Si, J | 1 |
| Beer, DG | 1 |
| Lambeth, D | 1 |
| Chin, YE | 1 |
| Leu, CM | 1 |
| Chang, C | 1 |
| Hu, C | 1 |
7 other studies available for pd 98059 and Cancer of Esophagus
| Article | Year |
|---|---|
Trichostatin A promotes esophageal squamous cell carcinoma cell migration and EMT through BRD4/ERK1/2-dependent pathway.
Topics: beta Catenin; Butadienes; Cadherins; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Shap | 2021 |
Expression of SLP-2 was associated with invasion of esophageal squamous cell carcinoma.
Topics: Blood Proteins; Blotting, Western; Butadienes; Carcinoma, Squamous Cell; Esophageal Neoplasms; Flavo | 2013 |
The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
Topics: Androstadienes; Antigen Presentation; Antigens, Neoplasm; Cell Line, Tumor; Epidermal Growth Factor; | 2013 |
[Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice].
Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2016 |
Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells.
Topics: Adenocarcinoma; Barrett Esophagus; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Enzyme I | 2011 |
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells.
Topics: Adenocarcinoma; Arachidonic Acids; Barrett Esophagus; Cell Line, Tumor; Enzyme Inhibitors; Esophagea | 2008 |
Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway.
Topics: Androstadienes; Apoptosis; Carcinoma; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, | 2000 |