pd 98059 has been researched along with Brain Neoplasms in 16 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously demonstrated that sulforaphane (SFN) inhibited invasion via sustained activation of ERK1/2 in human glioblastoma cells." | 7.85 | Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells. ( Geng, Y; Hu, Y; Lin, K; Tian, H; Wu, S; Wu, W; Yang, G; Zhou, Y, 2017) |
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 7.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "We have recently shown that endothelin-1 activates two types of Ca2+-permeable nonselective cation channels (NSCC-1 and NSCC-2) in C6 glioma cells." | 7.71 | Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells. ( Hashimoto, N; Kawanabe, Y; Masaki, T, 2002) |
| "Notably, co-treatment of C6 glioma cells with 400 µmol/l NaHS and AOAA (an inhibitor of CBS) largely suppressed the above NaHS-induced effects." | 5.42 | Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways. ( Chen, J; Feng, J; Guo, R; He, J; Liu, C; Lu, Y; Zhang, W; Zhang, Y; Zhen, Y, 2015) |
| "We previously demonstrated that sulforaphane (SFN) inhibited invasion via sustained activation of ERK1/2 in human glioblastoma cells." | 3.85 | Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells. ( Geng, Y; Hu, Y; Lin, K; Tian, H; Wu, S; Wu, W; Yang, G; Zhou, Y, 2017) |
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 3.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "We have recently shown that endothelin-1 activates two types of Ca2+-permeable nonselective cation channels (NSCC-1 and NSCC-2) in C6 glioma cells." | 3.71 | Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells. ( Hashimoto, N; Kawanabe, Y; Masaki, T, 2002) |
| "Notably, co-treatment of C6 glioma cells with 400 µmol/l NaHS and AOAA (an inhibitor of CBS) largely suppressed the above NaHS-induced effects." | 1.42 | Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways. ( Chen, J; Feng, J; Guo, R; He, J; Liu, C; Lu, Y; Zhang, W; Zhang, Y; Zhen, Y, 2015) |
| "We previously reported that BC brain metastases, in a rat syngeneic model developed in our laboratory, have high expression and activity of MMP2." | 1.34 | MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. ( Kim, HT; Lungu, G; Mendes, O; Stoica, G, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, S | 1 |
| Zhou, Y | 1 |
| Yang, G | 1 |
| Tian, H | 1 |
| Geng, Y | 1 |
| Hu, Y | 1 |
| Lin, K | 1 |
| Wu, W | 1 |
| Zhen, Y | 1 |
| Zhang, W | 1 |
| Liu, C | 1 |
| He, J | 1 |
| Lu, Y | 1 |
| Guo, R | 1 |
| Feng, J | 1 |
| Zhang, Y | 1 |
| Chen, J | 1 |
| Tencheva, TsS | 2 |
| Panov, IR | 2 |
| Kambe, A | 1 |
| Yoshioka, H | 1 |
| Kamitani, H | 1 |
| Watanabe, T | 1 |
| Baek, SJ | 1 |
| Eling, TE | 1 |
| Hueng, DY | 1 |
| Lin, GJ | 1 |
| Huang, SH | 1 |
| Liu, LW | 1 |
| Ju, DT | 1 |
| Chen, YW | 1 |
| Sytwu, HK | 1 |
| Chang, C | 1 |
| Huang, SM | 1 |
| Yeh, YS | 1 |
| Lee, HM | 1 |
| Ma, HI | 1 |
| Yanamandra, N | 1 |
| Gumidyala, KV | 1 |
| Waldron, KG | 1 |
| Gujrati, M | 1 |
| Olivero, WC | 1 |
| Dinh, DH | 1 |
| Rao, JS | 2 |
| Mohanam, S | 1 |
| Zhan, Y | 1 |
| O'Rourke, DM | 1 |
| Song, H | 1 |
| Moon, A | 1 |
| Mendes, O | 1 |
| Kim, HT | 1 |
| Lungu, G | 1 |
| Stoica, G | 1 |
| Hung, JJ | 1 |
| Cheng, TJ | 1 |
| Lai, YK | 1 |
| Chang, MD | 1 |
| Castigli, E | 1 |
| Arcuri, C | 1 |
| Giovagnoli, L | 2 |
| Luciani, R | 1 |
| Secca, T | 1 |
| Gianfranceschi, GL | 1 |
| Bocchini, V | 1 |
| Lakka, SS | 1 |
| Jasti, SL | 1 |
| Kyritsis, AP | 1 |
| Yung, WK | 1 |
| Ali-Osman, F | 1 |
| Nicolson, GL | 1 |
| Ramer, R | 1 |
| Brune, K | 1 |
| Pahl, A | 1 |
| Hinz, B | 1 |
| Hernández-Angeles, A | 1 |
| Soria-Jasso, LE | 1 |
| Ortega, A | 1 |
| Arias-Montaño, JA | 1 |
| Kawanabe, Y | 1 |
| Hashimoto, N | 1 |
| Masaki, T | 1 |
16 other studies available for pd 98059 and Brain Neoplasms
| Article | Year |
|---|---|
Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells.
Topics: Apoptosis; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine | 2017 |
Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways.
Topics: Animals; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclo | 2015 |
Intracerebral development of transplanted glioblastoma C6 cells in rats after preliminary exposure to neuropeptides and an MAPK inhibitor.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cell Prolife | 2008 |
The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells.
Topics: Activating Transcription Factor 3; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain | 2009 |
Inhibition of Nodal suppresses angiogenesis and growth of human gliomas.
Topics: Analysis of Variance; Animals; Benzamides; Brain Neoplasms; Cell Line, Transformed; Cell Proliferati | 2011 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; | 2004 |
SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival.
Topics: Brain Neoplasms; Cell Line, Tumor; Chromones; Enzyme Activation; ErbB Receptors; Flavonoids; Gliobla | 2004 |
Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Flavonoids; | 2006 |
MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2.
Topics: Animals; Astrocytes; Brain Neoplasms; Culture Media, Conditioned; Disease Models, Animal; Female; Fl | 2007 |
[Intracerebral progression of the transplanted rat C6 glioblastoma cells pretreated with neuropeptides and MAPK inhibitor].
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Brain Neoplasms; Cell Line, Tu | 2007 |
Differential activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases confers cadmium-induced HSP70 expression in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Cadmium Chloride; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucle | 1998 |
Interleukin-1beta induces apoptosis in GL15 glioblastoma-derived human cell line.
Topics: Antigens, Polyomavirus Transforming; Apoptosis; Brain Neoplasms; Cytoskeleton; DNA Fragmentation; En | 2000 |
Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.
Topics: Brain Neoplasms; Enzyme Inhibitors; Flavonoids; Glioma; Humans; JNK Mitogen-Activated Protein Kinase | 2000 |
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Recepto | 2001 |
Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.
Topics: Astrocytoma; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Ac | 2001 |
Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells.
Topics: Acetamides; Animals; Brain Neoplasms; Calcium; Calcium Channel Blockers; Calcium Channels; DNA; Drug | 2002 |