pd 98059 has been researched along with Brain Injuries in 4 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dexmedetomidine showed a protective effect on traumatically injured hippocampal cells with a maximum effect at a dosage of 1 μM." | 1.38 | Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury. ( Coburn, M; Eberhardt, G; Fahlenkamp, AV; Loetscher, PD; Rex, S; Rossaint, R; Schoeler, M; Weis, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhuo, X | 1 |
| Xie, L | 1 |
| Shi, FR | 1 |
| Li, N | 1 |
| Chen, X | 1 |
| Chen, M | 1 |
| Franke, H | 1 |
| Sauer, C | 1 |
| Rudolph, C | 1 |
| Krügel, U | 1 |
| Hengstler, JG | 1 |
| Illes, P | 1 |
| Schoeler, M | 1 |
| Loetscher, PD | 1 |
| Rossaint, R | 1 |
| Fahlenkamp, AV | 1 |
| Eberhardt, G | 1 |
| Rex, S | 1 |
| Weis, J | 1 |
| Coburn, M | 1 |
| Mori, T | 1 |
| Wang, X | 1 |
| Jung, JC | 1 |
| Sumii, T | 1 |
| Singhal, AB | 1 |
| Fini, ME | 1 |
| Dixon, CE | 1 |
| Alessandrini, A | 1 |
| Lo, EH | 1 |
4 other studies available for pd 98059 and Brain Injuries
| Article | Year |
|---|---|
The benefits of respective and combined use of green tea polyphenols and ERK inhibitor on the survival and neurologic outcomes in cardiac arrest rats induced by ventricular fibrillation.
Topics: Animals; Brain Injuries; Cardiopulmonary Resuscitation; Disease Models, Animal; Female; Flavonoids; | 2016 |
P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo.
Topics: Adenosine Diphosphate; Androstadienes; Animals; Apoptosis; Astrocytes; Brain Injuries; Disease Model | 2009 |
Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Injuries; Cell Count; Dexmedetomidine; Diseas | 2012 |
Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects.
Topics: Animals; Brain; Brain Injuries; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imida | 2002 |