pd 98059 has been researched along with Bone Loss, Osteoclastic in 9 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bradykinin (BK) is involved in bone resorption in chronic inflammatory diseases." | 1.38 | Chronic bradykinin treatment alters 1α,25-dihydroxyvitamin D3-induced calcium current modulation in pre-osteoblasts. ( Endoh, T; Sueishi, K; Tazaki, M; Uchida, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Russo, R | 1 |
| Mallia, S | 1 |
| Zito, F | 1 |
| Lampiasi, N | 1 |
| Iwasawa, M | 1 |
| Miyazaki, T | 1 |
| Nagase, Y | 1 |
| Akiyama, T | 1 |
| Kadono, Y | 1 |
| Nakamura, M | 1 |
| Oshima, Y | 1 |
| Yasui, T | 1 |
| Matsumoto, T | 1 |
| Nakamura, T | 1 |
| Kato, S | 1 |
| Hennighausen, L | 1 |
| Nakamura, K | 2 |
| Tanaka, S | 1 |
| Chen, W | 1 |
| Ma, Y | 1 |
| Ye, H | 1 |
| He, Y | 1 |
| Li, X | 1 |
| Li, J | 1 |
| Zhu, Z | 1 |
| Wang, H | 1 |
| Uchida, Y | 1 |
| Endoh, T | 1 |
| Tazaki, M | 1 |
| Sueishi, K | 1 |
| Collin-Osdoby, P | 1 |
| Rothe, L | 1 |
| Bekker, S | 1 |
| Anderson, F | 1 |
| Huang, Y | 1 |
| Osdoby, P | 1 |
| Bai, XC | 1 |
| Lu, D | 1 |
| Liu, AL | 1 |
| Zhang, ZM | 1 |
| Li, XM | 1 |
| Zou, ZP | 1 |
| Zeng, WS | 1 |
| Cheng, BL | 1 |
| Luo, SQ | 1 |
| Ahlstrom, M | 1 |
| Pekkinen, M | 1 |
| Riehle, U | 1 |
| Lamberg-Allardt, C | 1 |
| Katagiri, M | 1 |
| Hakeda, Y | 2 |
| Chikazu, D | 1 |
| Ogasawara, T | 1 |
| Takato, T | 1 |
| Kumegawa, M | 2 |
| Kawaguchi, H | 1 |
| Sobue, T | 1 |
| Kobayashi, Y | 1 |
| Hayakawa, H | 1 |
| Yamashita, K | 1 |
| Aoki, T | 1 |
| Noguchi, T | 1 |
| Hayakawa, T | 1 |
9 other studies available for pd 98059 and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Long-Lasting Activity of ERK Kinase Depends on NFATc1 Induction and Is Involved in Cell Migration-Fusion in Murine Macrophages RAW264.7.
Topics: Animals; Bone Resorption; Cell Differentiation; Cell Movement; Flavonoids; Macrophage Colony-Stimula | 2020 |
The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice.
Topics: Animals; bcl-X Protein; Biphenyl Compounds; Bone and Bones; Bone Resorption; Cell Survival; Cells, C | 2009 |
ERK1/2 is involved in cyclic compressive force-induced IL-6 secretion in MLO-Y4 cells.
Topics: Animals; Bone Resorption; Cell Line; Cell Survival; Compressive Strength; Flavonoids; Interleukin-6; | 2010 |
Chronic bradykinin treatment alters 1α,25-dihydroxyvitamin D3-induced calcium current modulation in pre-osteoblasts.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Barium; Bone Resorption; Bradykinin; Calcit | 2012 |
Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro.
Topics: Allantois; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Chick Embryo; Chorion; C | 2002 |
Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast.
Topics: Animals; Bone Resorption; Carrier Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Cells | 2005 |
Extracellular calcium regulates parathyroid hormone-related peptide expression in osteoblasts and osteoblast progenitor cells.
Topics: Bone Resorption; Calcium; Core Binding Factor Alpha 1 Subunit; Dactinomycin; Female; Flavonoids; Gen | 2008 |
Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts.
Topics: Animals; Blotting, Northern; Blotting, Western; Bone Marrow Cells; Bone Resorption; Cell Differentia | 2001 |
Tissue inhibitor of metalloproteinases 1 and 2 directly stimulate the bone-resorbing activity of isolated mature osteoclasts.
Topics: Acetamides; Animals; Benzoquinones; Bone Resorption; Butadienes; Cells, Cultured; Dipeptides; Flavon | 2001 |