pd 98059 has been researched along with Blood Pressure, High in 24 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Angiotensin II (AngII) is the most important component of angiotensin, which has been regarded as a major contributor to the incidence of hypertension and vascular endothelial dysfunction." | 7.85 | Adipokine CTRP6 improves PPARγ activation to alleviate angiotensin II-induced hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats. ( Bai, T; Chi, L; Guo, R; Hu, X; Tian, H; Zeng, H; Zhang, L; Zhang, W; Zhang, Y, 2017) |
| "We investigated if extracellular signal-regulated kinases (ERK) and oxidative stress are involved in the pathogenesis of arterial hypertension induced by chronic leptin administration in the rat." | 7.74 | Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension. ( Bełtowski, J; Jamroz-Wiśniewska, A; Ksiazek, M; Widomska, S; Wójcicka, G, 2008) |
| "Angiotensin II (AngII) is the most important component of angiotensin, which has been regarded as a major contributor to the incidence of hypertension and vascular endothelial dysfunction." | 3.85 | Adipokine CTRP6 improves PPARγ activation to alleviate angiotensin II-induced hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats. ( Bai, T; Chi, L; Guo, R; Hu, X; Tian, H; Zeng, H; Zhang, L; Zhang, W; Zhang, Y, 2017) |
| "We investigated if extracellular signal-regulated kinases (ERK) and oxidative stress are involved in the pathogenesis of arterial hypertension induced by chronic leptin administration in the rat." | 3.74 | Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension. ( Bełtowski, J; Jamroz-Wiśniewska, A; Ksiazek, M; Widomska, S; Wójcicka, G, 2008) |
| "Hypertension was induced in Sprague-Dawley rats by infusing angiotensin II (200 ng/kg per min) through osmotic pumps for 12 days." | 3.72 | NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells. ( de Champlain, J; El Midaoui, A; Laplante, MA; Wu, R, 2003) |
| "We investigated whether p42/p44 mitogen-activated protein kinase (MAPK) and/or p38 MAPK participates in the regulation of vascular smooth muscle contraction by endothelin-1 (ET-1) in Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR)." | 3.72 | p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats. ( Ahn, HY; Fang, LH; Ha, TS; Kim, B; Kwon, S; Lee, SJ, 2004) |
| " PD 098,059 does not alter the responses evoked by microinjection of glutamate into the RVLM or brief apnea." | 3.71 | Differential role of kinases in brain stem of hypertensive and normotensive rats. ( Goodchild, AK; Pilowsky, PM; Seyedabadi, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 16 (66.67) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, C | 1 |
| Li, N | 1 |
| Yuan, Y | 1 |
| Wang, R | 1 |
| Chen, J | 1 |
| Yang, J | 1 |
| Guo, Z | 1 |
| Wang, S | 1 |
| Zhang, Y | 2 |
| Liu, Y | 2 |
| Dong, J | 1 |
| Tang, X | 1 |
| Xiao, Q | 1 |
| Yao, Q | 1 |
| Allen, M | 1 |
| Wang, Y | 1 |
| Gao, L | 1 |
| Qi, Y | 1 |
| Zhang, P | 1 |
| Chi, L | 1 |
| Hu, X | 1 |
| Zhang, W | 1 |
| Bai, T | 1 |
| Zhang, L | 1 |
| Zeng, H | 1 |
| Guo, R | 1 |
| Tian, H | 1 |
| Cheng, WH | 1 |
| Lu, PJ | 1 |
| Ho, WY | 1 |
| Tung, CS | 1 |
| Cheng, PW | 1 |
| Hsiao, M | 1 |
| Tseng, CJ | 1 |
| Ljuca, F | 1 |
| Drevenšek, G | 1 |
| Zerem, E | 1 |
| Jing, L | 1 |
| Zhang, J | 1 |
| Sun, J | 1 |
| Guo, F | 1 |
| An, X | 1 |
| Yang, K | 1 |
| Li, PA | 1 |
| Carter, RW | 1 |
| Kanagy, NL | 1 |
| Laplante, MA | 1 |
| Wu, R | 1 |
| El Midaoui, A | 1 |
| de Champlain, J | 1 |
| Kim, B | 4 |
| Kim, J | 4 |
| Bae, YM | 2 |
| Cho, SI | 1 |
| Kwon, SC | 1 |
| Jung, JY | 1 |
| Park, JC | 1 |
| Ahn, HY | 2 |
| Kwon, S | 1 |
| Fang, LH | 1 |
| Ha, TS | 1 |
| Lee, SJ | 1 |
| Lee, YR | 1 |
| Lee, CH | 1 |
| Choi, WH | 1 |
| Lee, CK | 2 |
| Cho, S | 1 |
| Lappas, G | 1 |
| Daou, GB | 1 |
| Anand-Srivastava, MB | 1 |
| Ryu, SK | 1 |
| Ahn, DS | 1 |
| Cho, YE | 1 |
| Choi, SK | 1 |
| Kim, YH | 1 |
| Morgan, KG | 1 |
| Lee, YH | 1 |
| Won, KJ | 1 |
| Lee, HM | 1 |
| Kim, HJ | 1 |
| Roh, HY | 1 |
| Park, HJ | 1 |
| Shin, HS | 1 |
| Park, TK | 1 |
| Lee, SM | 1 |
| Ding, L | 1 |
| Chapman, A | 1 |
| Boyd, R | 1 |
| Wang, HD | 1 |
| Wójcicka, G | 1 |
| Jamroz-Wiśniewska, A | 1 |
| Widomska, S | 1 |
| Ksiazek, M | 1 |
| Bełtowski, J | 1 |
| Touyz, RM | 3 |
| El Mabrouk, M | 2 |
| He, G | 3 |
| Wu, XH | 1 |
| Schiffrin, EL | 3 |
| Hamaguchi, A | 1 |
| Kim, S | 1 |
| Izumi, Y | 1 |
| Zhan, Y | 1 |
| Yamanaka, S | 1 |
| Iwao, H | 1 |
| Samain, E | 1 |
| Bouillier, H | 1 |
| Miserey, S | 1 |
| Perret, C | 1 |
| Renaud, JF | 1 |
| Safar, M | 1 |
| Dagher, G | 1 |
| Muthalif, MM | 2 |
| Benter, IF | 2 |
| Khandekar, Z | 2 |
| Gaber, L | 2 |
| Estes, A | 2 |
| Malik, S | 1 |
| Parmentier, JH | 2 |
| Manne, V | 1 |
| Malik, KU | 2 |
| Karzoun, NA | 1 |
| Saeed, AE | 1 |
| Diep, Q | 1 |
| Mardigyan, V | 1 |
| Seyedabadi, M | 1 |
| Goodchild, AK | 1 |
| Pilowsky, PM | 1 |
| Deschepper, C | 1 |
| Park, JB | 1 |
| Chen, X | 1 |
| Neves, MF | 1 |
| Virdis, A | 1 |
24 other studies available for pd 98059 and Blood Pressure, High
| Article | Year |
|---|---|
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pres | 2018 |
Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway.
Topics: Adrenocorticotropic Hormone; Animals; Biomechanical Phenomena; Cell Proliferation; Disease Models, A | 2018 |
Adipokine CTRP6 improves PPARγ activation to alleviate angiotensin II-induced hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats.
Topics: Adipokines; Angiotensin II; Animals; Apoptosis; Blood Pressure; Brain; Cell Separation; Coronary Ves | 2017 |
Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Antioxida | 2010 |
Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension.
Topics: Alkyl and Aryl Transferases; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme Syst | 2011 |
Inhibition of extracellular signal-regulated kinases ameliorates hypertension-induced renal vascular remodeling in rat models.
Topics: Animals; Endothelium, Vascular; Female; Flavonoids; Hypertension; Male; MAP Kinase Signaling System; | 2011 |
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavono | 2002 |
NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Disease Model | 2003 |
p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats.
Topics: Animals; Aorta; Calmodulin-Binding Proteins; Desoxycorticosterone; Endothelin-1; Flavonoids; Hyperte | 2004 |
p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats.
Topics: Animals; Endothelin-1; Enzyme Inhibitors; Flavonoids; Hypertension; Imidazoles; Mitogen-Activated Pr | 2004 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, | 2005 |
Oxidative stress contributes to the enhanced expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Acetylcysteine; Adenylyl Cyclases; Animals; Antioxidants; Cells, Cultured; Colforsin; Flavonoids; GT | 2005 |
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.
Topics: Amides; Animals; Calcium; Flavonoids; Hypertension; Mesenteric Arteries; Mitogen-Activated Protein K | 2006 |
Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Desoxycorticosterone; Enzyme Inhibitors; Flav | 2006 |
ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Butadienes; Disease Models, Animal; Endoth | 2007 |
Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension.
Topics: Animals; Aorta; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Drug Administration Schedul | 2008 |
Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enz | 1999 |
Contribution of extracellular signal-regulated kinase to angiotensin II-induced transforming growth factor-beta1 expression in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Calcium-Calmodulin-Dependent Prote | 1999 |
Extracellular signal-regulated kinase pathway is involved in basic fibroblast growth factor effect on angiotensin II-induced Ca(2+) transient in vascular smooth muscle cell from Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Calcium; Calcium Signaling; Cell Size; DNA; Enzyme Inhibitors; Fibroblast G | 2000 |
Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.
Topics: Alkyl and Aryl Transferases; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Desoxycorticos | 2000 |
Angiotensin II-induced hypertension: contribution of Ras GTPase/Mitogen-activated protein kinase and cytochrome P450 metabolites.
Topics: Alkyl and Aryl Transferases; Angiotensin II; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Cytoch | 2000 |
Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hypertension; Imidazoles; | 2001 |
Differential role of kinases in brain stem of hypertensive and normotensive rats.
Topics: Androstadienes; Angiotensin II; Animals; Apnea; Blood Pressure; Brain Stem; Enzyme Inhibitors; Flavo | 2001 |
Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Hyper | 2002 |