pd 98059 has been researched along with Benign Neoplasms in 17 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After treating the ovarian cancer cells with 11." | 1.37 | The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro. ( Borrelli, A; Capasso, C; De Luca, V; Gori, E; Mancini, A; Mancini, R; Morelli, F; Schiattarella, A, 2011) |
| "The nanoparticles are taken up by cancer cells through endocytosis and demonstrate sustained release of the active agent, resulting in the inhibition of phosphorylation of downstream extracellular signal regulated kinase." | 1.35 | Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy. ( Basu, S; Chimote, G; Harfouche, R; Mashelkar, RA; Sengupta, S; Soni, S, 2009) |
| "Tumorigenic breast cancer cells, BT474, Cama, MCF-7, MDA-MB-231 and SKBR3, did not show inhibition of MAP kinase phosphorylation but rather enhanced MAP kinase phosphorylation when cultured at high density on fibronectin-coated substrates." | 1.31 | Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase. ( Bewick, M; Lafrenie, RM; Zhang, L, 2002) |
| "However, NSAIDs produce gastroduodenal ulcers in about 25% of users (often with bleeding and/or perforations) and delay ulcer healing, presumably by blocking prostaglandin synthesis from cyclooxygenase (COX)-1 and COX-2 (ref." | 1.30 | Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. ( Itani, RM; Jones, MK; Levin, E; Peskar, BM; Sarfeh, IJ; Tarnawski, AS; Wang, H, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Chang, WW | 1 |
| Lai, CH | 1 |
| Chen, MC | 1 |
| Liu, CF | 1 |
| Kuan, YD | 1 |
| Lin, ST | 1 |
| Lee, CH | 1 |
| Noh, KH | 1 |
| Kim, SH | 1 |
| Kim, JH | 1 |
| Song, KH | 1 |
| Lee, YH | 1 |
| Kang, TH | 1 |
| Han, HD | 1 |
| Sood, AK | 1 |
| Ng, J | 1 |
| Kim, K | 1 |
| Sonn, CH | 1 |
| Kumar, V | 1 |
| Yee, C | 1 |
| Lee, KM | 1 |
| Kim, TW | 1 |
| Tanimura, S | 2 |
| Uchiyama, A | 1 |
| Watanabe, K | 2 |
| Yasunaga, M | 1 |
| Inada, Y | 1 |
| Kawabata, T | 1 |
| Iwashita, K | 1 |
| Noda, S | 1 |
| Ozaki, K | 1 |
| Kohno, M | 3 |
| Basu, S | 1 |
| Harfouche, R | 1 |
| Soni, S | 1 |
| Chimote, G | 1 |
| Mashelkar, RA | 1 |
| Sengupta, S | 1 |
| Borrelli, A | 1 |
| Schiattarella, A | 1 |
| Mancini, R | 1 |
| Morelli, F | 1 |
| Capasso, C | 1 |
| De Luca, V | 1 |
| Gori, E | 1 |
| Mancini, A | 1 |
| Larroque-Lombard, AL | 1 |
| Todorova, M | 1 |
| Qiyu, Q | 1 |
| Jean-Claude, B | 1 |
| Jeon, HW | 1 |
| Lee, KJ | 1 |
| Lee, SH | 1 |
| Kim, WH | 1 |
| Lee, YM | 1 |
| Tothova, V | 1 |
| Isola, J | 1 |
| Parkkila, S | 1 |
| Kopacek, J | 1 |
| Pastorek, J | 1 |
| Pastorekova, S | 1 |
| Gibadulinova, A | 1 |
| Zhang, L | 1 |
| Bewick, M | 1 |
| Lafrenie, RM | 1 |
| Yanamandra, N | 1 |
| Gumidyala, KV | 1 |
| Waldron, KG | 1 |
| Gujrati, M | 1 |
| Olivero, WC | 1 |
| Dinh, DH | 1 |
| Rao, JS | 1 |
| Mohanam, S | 1 |
| Hu, JG | 1 |
| Hou, YQ | 1 |
| Li, BQ | 1 |
| Strickland, LA | 1 |
| Jubb, AM | 1 |
| Hongo, JA | 1 |
| Zhong, F | 1 |
| Burwick, J | 1 |
| Fu, L | 1 |
| Frantz, GD | 1 |
| Koeppen, H | 1 |
| Jones, MK | 1 |
| Wang, H | 1 |
| Peskar, BM | 1 |
| Levin, E | 1 |
| Itani, RM | 1 |
| Sarfeh, IJ | 1 |
| Tarnawski, AS | 1 |
| Samid, D | 1 |
| Wells, M | 1 |
| Greene, ME | 1 |
| Shen, W | 1 |
| Palmer, CN | 1 |
| Thibault, A | 1 |
| Hoshino, R | 2 |
| Kataoka, T | 1 |
1 review available for pd 98059 and Benign Neoplasms
| Article | Year |
|---|---|
[Constitutive activation of the ERK-MAP kinase pathway in human tumors].
Topics: Apoptosis; Cell Division; Enzyme Inhibitors; Flavonoids; G1 Phase; Humans; MAP Kinase Signaling Syst | 2000 |
16 other studies available for pd 98059 and Benign Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Salmonella enhance chemosensitivity in tumor through connexin 43 upregulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Therapy; Cell Communication; Cell Line, Tumor; | 2013 |
API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; CD8-Positive T-Lymphocytes | 2014 |
Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells.
Topics: Apoptosis; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Microtu | 2009 |
Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Delivery Systems; Endocytosis; Enzyme Inhibitors; Fl | 2009 |
The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro.
Topics: Antineoplastic Agents; bcl-2-Associated X Protein; Cell Line, Tumor; Cisplatin; Drug Carriers; Extra | 2011 |
Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK.
Topics: Acetylation; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chromatography, L | 2011 |
Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways.
Topics: Anthracenes; Cell Hypoxia; Cell Line, Tumor; Down-Regulation; Flavonoids; GPI-Linked Proteins; HEK29 | 2011 |
Glucocorticoid receptor-mediated transcriptional activation of S100P gene coding for cancer-related calcium-binding protein.
Topics: Base Sequence; Blotting, Western; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kin | 2011 |
Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase.
Topics: Antigens, CD; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Communication; Cell | 2002 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; | 2004 |
[The role of MAPK signal transduction pathway in killing tumor cells by Mtb-Ag activated gammadelta T cells].
Topics: Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Cell Line, Tumor; Cell P | 2005 |
Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF).
Topics: Carrier Proteins; Cell Line, Tumor; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors | 2005 |
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase | 1999 |
Peroxisome proliferator-activated receptor gamma as a novel target in cancer therapy: binding and activation by an aromatic fatty acid with clinical antitumor activity.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibito | 2000 |
Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1).
Topics: Antineoplastic Agents; Apoptosis; Butadienes; Enzyme Inhibitors; Flavonoids; G1 Phase; Humans; Mitog | 2001 |