pd 98059 has been researched along with B16 Melanoma in 18 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Migration in gastric cancer cells, SNU638 and SNU668, was dependent on a relative expression level of Tβ4." | 1.38 | Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration. ( Kim, YS; Lee, GH; Lee, YS; Moon, EY; Ryu, YK; Song, KS, 2012) |
| "Acteoside is a phenylpropanoid glycoside extracted from the leaves of Rehmannia glutinosa that displays various biological activities." | 1.37 | Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation. ( Chun, JC; Jang, YS; Kim, SS; Lee, JC; Lee, SA; Son, YO, 2011) |
| "The nanoparticles are taken up by cancer cells through endocytosis and demonstrate sustained release of the active agent, resulting in the inhibition of phosphorylation of downstream extracellular signal regulated kinase." | 1.35 | Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy. ( Basu, S; Chimote, G; Harfouche, R; Mashelkar, RA; Sengupta, S; Soni, S, 2009) |
| "Melanoma is a malignant skin cancer that displays a high rate of tumor cell migration and metastasis." | 1.34 | Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10. ( Bang, SI; Cho, D; Kim, TS; Park, H; Yang, Y, 2007) |
| "Importantly, in vivo treatment of human melanoma xenograft tumors in athymic nude mice with LeTx results in significant or complete tumor regression without apparent side effects, suggesting that inhibiting the MAPK signaling pathway may be a useful strategy for treating melanoma." | 1.31 | Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. ( Duesbery, NS; Koo, HM; Leppla, SH; McWilliams, MJ; VanBrocklin, M; Vande Woude, GF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 12 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakashima, S | 1 |
| Matsuda, H | 1 |
| Oda, Y | 1 |
| Nakamura, S | 1 |
| Xu, F | 1 |
| Yoshikawa, M | 1 |
| Lim, JW | 1 |
| Ha, JH | 1 |
| Jeong, YJ | 1 |
| Park, SN | 1 |
| Kim, JY | 1 |
| Lee, EJ | 1 |
| Ahn, Y | 1 |
| Park, S | 1 |
| Kim, SH | 1 |
| Oh, SH | 1 |
| Yan, G | 1 |
| Zhu, J | 1 |
| Zhang, L | 1 |
| Xu, Z | 1 |
| Wang, G | 1 |
| Zhu, W | 1 |
| Hou, A | 1 |
| Wang, H | 1 |
| Liu, J | 1 |
| Li, J | 1 |
| Zeng, X | 1 |
| Rao, Z | 1 |
| Gao, J | 1 |
| Zhang, B | 1 |
| Zhao, Y | 1 |
| Yang, B | 1 |
| Wang, Z | 1 |
| Yu, L | 1 |
| Wang, W | 1 |
| Ng, LT | 1 |
| Lin, LT | 1 |
| Chen, CL | 1 |
| Chen, HW | 1 |
| Wu, SJ | 1 |
| Lin, CC | 1 |
| Basu, S | 1 |
| Harfouche, R | 1 |
| Soni, S | 1 |
| Chimote, G | 1 |
| Mashelkar, RA | 1 |
| Sengupta, S | 1 |
| Jang, JY | 1 |
| Lee, JH | 1 |
| Shin, HK | 1 |
| Choi, YH | 1 |
| Lee, JD | 1 |
| Choi, BT | 1 |
| Chang, SP | 1 |
| Shen, SC | 1 |
| Lee, WR | 1 |
| Yang, LL | 1 |
| Chen, YC | 1 |
| Son, YO | 1 |
| Lee, SA | 1 |
| Kim, SS | 1 |
| Jang, YS | 1 |
| Chun, JC | 1 |
| Lee, JC | 1 |
| Ryu, YK | 1 |
| Lee, YS | 1 |
| Lee, GH | 1 |
| Song, KS | 1 |
| Kim, YS | 1 |
| Moon, EY | 1 |
| Kawaguchi, M | 1 |
| Valencia, JC | 1 |
| Namiki, T | 1 |
| Suzuki, T | 1 |
| Hearing, VJ | 1 |
| Kim, HE | 1 |
| Ishihara, A | 1 |
| Lee, SG | 1 |
| Jung, MK | 1 |
| Song, HK | 1 |
| Kim, KE | 1 |
| Hur, DY | 1 |
| Kim, T | 1 |
| Bang, S | 1 |
| Park, H | 2 |
| Cho, DH | 1 |
| Yang, Y | 2 |
| Kim, TS | 1 |
| Bang, SI | 1 |
| Cho, D | 1 |
| Hayashi, C | 1 |
| Rittling, S | 1 |
| Hayata, T | 1 |
| Amagasa, T | 1 |
| Denhardt, D | 1 |
| Ezura, Y | 1 |
| Nakashima, K | 1 |
| Noda, M | 1 |
| Englaro, W | 1 |
| Bertolotto, C | 1 |
| Buscà, R | 1 |
| Brunet, A | 1 |
| Pagès, G | 1 |
| Ortonne, JP | 1 |
| Ballotti, R | 1 |
| Koo, HM | 1 |
| VanBrocklin, M | 1 |
| McWilliams, MJ | 1 |
| Leppla, SH | 1 |
| Duesbery, NS | 1 |
| Vande Woude, GF | 1 |
18 other studies available for pd 98059 and B16 Melanoma
| Article | Year |
|---|---|
Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.
Topics: Agaricales; Animals; Antineoplastic Agents; Brassicaceae; Cell Proliferation; Cell Survival; Drug Sc | 2010 |
Anti-melanogenesis effect of dehydroglyasperin C through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16F1 melanoma cells.
Topics: alpha-MSH; Animals; Benzopyrans; Cell Line, Tumor; Cell Survival; Cyclic AMP; Dose-Response Relation | 2018 |
A chemical compound from fruit extract of Juglans mandshurica inhibits melanogenesis through p-ERK-associated MITF degradation.
Topics: Animals; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fruit | 2019 |
Dodoviscin a inhibits melanogenesis in mouse b16-f10 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-B | 2013 |
Formyl peptide receptor suppresses melanoma development and promotes NK cell migration.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Activation; Extracellular Signa | 2014 |
Anti-melanogenic effects of δ-tocotrienol are associated with tyrosinase-related proteins and MAPK signaling pathway in B16 melanoma cells.
Topics: Animals; Cell Line, Tumor; Cell Survival; Flavonoids; Indoles; Intramolecular Oxidoreductases; MAP K | 2014 |
Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Delivery Systems; Endocytosis; Enzyme Inhibitors; Fl | 2009 |
Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells.
Topics: Animals; Araceae; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; MAP Kina | 2010 |
Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Benzamides; Flavonoids; Flow Cytometry; Imat | 2011 |
Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation.
Topics: alpha-MSH; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Extracellular Si | 2011 |
Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.
Topics: Animals; beta Catenin; Butadienes; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Lin | 2012 |
Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes.
Topics: Adenoviridae; alpha-MSH; Animals; Cell Line, Tumor; Diacylglycerol Kinase; Endoplasmic Reticulum; En | 2012 |
The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells.
Topics: alpha-MSH; Animals; Caffeic Acids; Cell Differentiation; Cell Line, Tumor; Cyclic AMP; Down-Regulati | 2012 |
IL-18 enhances the migration ability of murine melanoma cells through the generation of ROI and the MAPK pathway.
Topics: Acetylcysteine; Animals; Cell Movement; Flavonoids; Free Radical Scavengers; Interleukin-18; Melanom | 2006 |
Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10.
Topics: Animals; Cell Line, Tumor; Cell Movement; Corticotropin-Releasing Hormone; Dose-Response Relationshi | 2007 |
Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration.
Topics: 3T3 Cells; Animals; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Flavonoids; | 2007 |
Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Colforsin; Cyclic AMP; | 1998 |
Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase.
Topics: Adenylyl Cyclases; Animals; Antigens, Bacterial; Apoptosis; Bacillus anthracis; Bacterial Toxins; Ce | 2002 |