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pd 98059 and B16 Melanoma

pd 98059 has been researched along with B16 Melanoma in 18 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Research Excerpts

ExcerptRelevanceReference
"Migration in gastric cancer cells, SNU638 and SNU668, was dependent on a relative expression level of Tβ4."1.38Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration. ( Kim, YS; Lee, GH; Lee, YS; Moon, EY; Ryu, YK; Song, KS, 2012)
"Acteoside is a phenylpropanoid glycoside extracted from the leaves of Rehmannia glutinosa that displays various biological activities."1.37Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation. ( Chun, JC; Jang, YS; Kim, SS; Lee, JC; Lee, SA; Son, YO, 2011)
"The nanoparticles are taken up by cancer cells through endocytosis and demonstrate sustained release of the active agent, resulting in the inhibition of phosphorylation of downstream extracellular signal regulated kinase."1.35Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy. ( Basu, S; Chimote, G; Harfouche, R; Mashelkar, RA; Sengupta, S; Soni, S, 2009)
"Melanoma is a malignant skin cancer that displays a high rate of tumor cell migration and metastasis."1.34Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10. ( Bang, SI; Cho, D; Kim, TS; Park, H; Yang, Y, 2007)
"Importantly, in vivo treatment of human melanoma xenograft tumors in athymic nude mice with LeTx results in significant or complete tumor regression without apparent side effects, suggesting that inhibiting the MAPK signaling pathway may be a useful strategy for treating melanoma."1.31Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. ( Duesbery, NS; Koo, HM; Leppla, SH; McWilliams, MJ; VanBrocklin, M; Vande Woude, GF, 2002)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.56)18.2507
2000's5 (27.78)29.6817
2010's12 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nakashima, S1
Matsuda, H1
Oda, Y1
Nakamura, S1
Xu, F1
Yoshikawa, M1
Lim, JW1
Ha, JH1
Jeong, YJ1
Park, SN1
Kim, JY1
Lee, EJ1
Ahn, Y1
Park, S1
Kim, SH1
Oh, SH1
Yan, G1
Zhu, J1
Zhang, L1
Xu, Z1
Wang, G1
Zhu, W1
Hou, A1
Wang, H1
Liu, J1
Li, J1
Zeng, X1
Rao, Z1
Gao, J1
Zhang, B1
Zhao, Y1
Yang, B1
Wang, Z1
Yu, L1
Wang, W1
Ng, LT1
Lin, LT1
Chen, CL1
Chen, HW1
Wu, SJ1
Lin, CC1
Basu, S1
Harfouche, R1
Soni, S1
Chimote, G1
Mashelkar, RA1
Sengupta, S1
Jang, JY1
Lee, JH1
Shin, HK1
Choi, YH1
Lee, JD1
Choi, BT1
Chang, SP1
Shen, SC1
Lee, WR1
Yang, LL1
Chen, YC1
Son, YO1
Lee, SA1
Kim, SS1
Jang, YS1
Chun, JC1
Lee, JC1
Ryu, YK1
Lee, YS1
Lee, GH1
Song, KS1
Kim, YS1
Moon, EY1
Kawaguchi, M1
Valencia, JC1
Namiki, T1
Suzuki, T1
Hearing, VJ1
Kim, HE1
Ishihara, A1
Lee, SG1
Jung, MK1
Song, HK1
Kim, KE1
Hur, DY1
Kim, T1
Bang, S1
Park, H2
Cho, DH1
Yang, Y2
Kim, TS1
Bang, SI1
Cho, D1
Hayashi, C1
Rittling, S1
Hayata, T1
Amagasa, T1
Denhardt, D1
Ezura, Y1
Nakashima, K1
Noda, M1
Englaro, W1
Bertolotto, C1
Buscà, R1
Brunet, A1
Pagès, G1
Ortonne, JP1
Ballotti, R1
Koo, HM1
VanBrocklin, M1
McWilliams, MJ1
Leppla, SH1
Duesbery, NS1
Vande Woude, GF1

Other Studies

18 other studies available for pd 98059 and B16 Melanoma

ArticleYear
Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Agaricales; Animals; Antineoplastic Agents; Brassicaceae; Cell Proliferation; Cell Survival; Drug Sc

2010
Anti-melanogenesis effect of dehydroglyasperin C through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16F1 melanoma cells.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:5

    Topics: alpha-MSH; Animals; Benzopyrans; Cell Line, Tumor; Cell Survival; Cyclic AMP; Dose-Response Relation

2018
A chemical compound from fruit extract of Juglans mandshurica inhibits melanogenesis through p-ERK-associated MITF degradation.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 57

    Topics: Animals; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fruit

2019
Dodoviscin a inhibits melanogenesis in mouse b16-f10 melanoma cells.
    Planta medica, 2013, Volume: 79, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-B

2013
Formyl peptide receptor suppresses melanoma development and promotes NK cell migration.
    Inflammation, 2014, Volume: 37, Issue:3

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Activation; Extracellular Signa

2014
Anti-melanogenic effects of δ-tocotrienol are associated with tyrosinase-related proteins and MAPK signaling pathway in B16 melanoma cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Jun-15, Volume: 21, Issue:7

    Topics: Animals; Cell Line, Tumor; Cell Survival; Flavonoids; Indoles; Intramolecular Oxidoreductases; MAP K

2014
Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, May-12, Volume: 106, Issue:19

    Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Delivery Systems; Endocytosis; Enzyme Inhibitors; Fl

2009
Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells.
    International journal of molecular medicine, 2010, Volume: 25, Issue:2

    Topics: Animals; Araceae; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; MAP Kina

2010
Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells.
    Journal of dermatological science, 2011, Volume: 62, Issue:3

    Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Benzamides; Flavonoids; Flow Cytometry; Imat

2011
Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation.
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:10

    Topics: alpha-MSH; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Extracellular Si

2011
Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.
    International journal of cancer, 2012, Nov-01, Volume: 131, Issue:9

    Topics: Animals; beta Catenin; Butadienes; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Lin

2012
Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes.
    The Journal of investigative dermatology, 2012, Volume: 132, Issue:12

    Topics: Adenoviridae; alpha-MSH; Animals; Cell Line, Tumor; Diacylglycerol Kinase; Endoplasmic Reticulum; En

2012
The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells.
    BMB reports, 2012, Volume: 45, Issue:12

    Topics: alpha-MSH; Animals; Caffeic Acids; Cell Differentiation; Cell Line, Tumor; Cyclic AMP; Down-Regulati

2012
IL-18 enhances the migration ability of murine melanoma cells through the generation of ROI and the MAPK pathway.
    Immunology letters, 2006, Nov-15, Volume: 107, Issue:2

    Topics: Acetylcysteine; Animals; Cell Movement; Flavonoids; Free Radical Scavengers; Interleukin-18; Melanom

2006
Enhancement of cell migration by corticotropin-releasing hormone through ERK1/2 pathway in murine melanoma cell line, B16F10.
    Experimental dermatology, 2007, Volume: 16, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Movement; Corticotropin-Releasing Hormone; Dose-Response Relationshi

2007
Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration.
    Journal of cellular biochemistry, 2007, Jul-01, Volume: 101, Issue:4

    Topics: 3T3 Cells; Animals; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Flavonoids;

2007
Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation.
    The Journal of biological chemistry, 1998, Apr-17, Volume: 273, Issue:16

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Colforsin; Cyclic AMP;

1998
Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Mar-05, Volume: 99, Issue:5

    Topics: Adenylyl Cyclases; Animals; Antigens, Bacterial; Apoptosis; Bacillus anthracis; Bacterial Toxins; Ce

2002