pd 98059 has been researched along with Asystole in 5 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation activation and necroptosis involved in CA/CPR-induced CIRI were regulated by the ERK/calpain-2 signaling pathway." | 8.02 | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. ( Chen, MH; Li, N; Tian, XY; Wang, WY; Wu, ZJ; Xie, L; Yang, YG; Zhao, GY; Zou, XS, 2021) |
| "Inflammation activation and necroptosis involved in CA/CPR-induced CIRI were regulated by the ERK/calpain-2 signaling pathway." | 4.02 | Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest. ( Chen, MH; Li, N; Tian, XY; Wang, WY; Wu, ZJ; Xie, L; Yang, YG; Zhao, GY; Zou, XS, 2021) |
| "The clinical and experimental postcardiac arrest treatment has not reached therapeutic success." | 1.43 | PD98059 Protects Brain against Cells Death Resulting from ROS/ERK Activation in a Cardiac Arrest Rat Model. ( Chen, MH; Li, N; Nguyen Thi, PA; Xie, L; Zhuo, XJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, JH | 2 |
| Chen, MH | 4 |
| Fu, ZY | 2 |
| Li, N | 5 |
| Xie, L | 5 |
| Wang, WY | 1 |
| Zou, XS | 1 |
| Yang, YG | 1 |
| Wu, ZJ | 1 |
| Tian, XY | 1 |
| Zhao, GY | 1 |
| Tan, XF | 1 |
| Tao, R | 1 |
| Qin, T | 1 |
| Zhuo, X | 1 |
| Shi, FR | 1 |
| Chen, X | 1 |
| Chen, M | 1 |
| Nguyen Thi, PA | 1 |
| Zhuo, XJ | 1 |
5 other studies available for pd 98059 and Asystole
| Article | Year |
|---|---|
PD98059 Protects Cerebral Cortex Mitochondrial Structure and Function at 48 h Post-Resuscitation in a Rat Model of Cardiac Arrest.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Flavonoids; Hear | 2020 |
Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest.
Topics: Animals; Brain Ischemia; Calpain; Dipeptides; Disease Models, Animal; Extracellular Signal-Regulated | 2021 |
PD98059 protects the brain against mitochondrial-mediated apoptosis and autophagy in a cardiac arrest rat model.
Topics: Animals; Apoptosis; Autophagy; Brain; Cardiopulmonary Resuscitation; Cerebral Cortex; Disease Models | 2019 |
The benefits of respective and combined use of green tea polyphenols and ERK inhibitor on the survival and neurologic outcomes in cardiac arrest rats induced by ventricular fibrillation.
Topics: Animals; Brain Injuries; Cardiopulmonary Resuscitation; Disease Models, Animal; Female; Flavonoids; | 2016 |
PD98059 Protects Brain against Cells Death Resulting from ROS/ERK Activation in a Cardiac Arrest Rat Model.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; DNA Fragmentation; Down-Regulation; Flavonoids; H | 2016 |