pd 98059 has been researched along with Astrocytoma in 9 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 7.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 3.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "Phenserine treatment resulted in decreased secretion of soluble betaAPP and Abeta into the conditioned media of human neuroblastoma cells without cellular toxicity." | 1.31 | Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. ( Brossi, A; Ge, YW; Greig, NH; Lahiri, DK; Rogers, J; Sambamurti, K; Shaw, KT; Utsuki, T; Yu, QS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, MS | 1 |
| Jo, H | 1 |
| Um, JY | 1 |
| Yi, JM | 1 |
| Kim, DK | 1 |
| Choi, SC | 1 |
| Kim, TH | 1 |
| Nah, YH | 1 |
| Kim, HM | 1 |
| Lee, YM | 1 |
| Zaheer, A | 1 |
| Sahu, SK | 1 |
| Ryken, TC | 1 |
| Traynelis, VC | 1 |
| Belsey, MJ | 1 |
| Davies, AR | 1 |
| Witchel, HJ | 1 |
| Kozlowski, RZ | 1 |
| Kambe, A | 1 |
| Iguchi, G | 1 |
| Moon, Y | 1 |
| Kamitani, H | 1 |
| Watanabe, T | 1 |
| Eling, TE | 1 |
| Luo, W | 1 |
| Sharif, TR | 1 |
| Sharif, M | 1 |
| Navarro, L | 1 |
| David, M | 1 |
| Shaw, KT | 1 |
| Utsuki, T | 1 |
| Rogers, J | 1 |
| Yu, QS | 1 |
| Sambamurti, K | 1 |
| Brossi, A | 1 |
| Ge, YW | 1 |
| Lahiri, DK | 1 |
| Greig, NH | 1 |
| Hernández-Angeles, A | 1 |
| Soria-Jasso, LE | 1 |
| Ortega, A | 1 |
| Arias-Montaño, JA | 1 |
| Kuruganti, PA | 1 |
| Wurster, RD | 1 |
| Lucchesi, PA | 1 |
9 other studies available for pd 98059 and Astrocytoma
| Article | Year |
|---|---|
Agonists of proteinase-activated receptor 2 induce TNF-alpha secretion from astrocytoma cells.
Topics: Astrocytoma; Blotting, Western; Calcium; Central Nervous System; Chymases; Cytokines; Enzyme Activat | 2002 |
Cis-parinaric acid effects, cytotoxicity, c-Jun N-terminal protein kinase, forkhead transcription factor and Mn-SOD differentially in malignant and normal astrocytes.
Topics: Animals; Astrocytes; Astrocytoma; Cell Line, Tumor; Cell Survival; Curcumin; Fatty Acids, Unsaturate | 2007 |
Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anthracenes; Apoptosis; Astrocytoma; Cell | 2007 |
Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.
Topics: Antineoplastic Agents; Astrocytoma; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; | 2008 |
Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway.
Topics: Amino Acid Sequence; Animals; Astrocytoma; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein | 1996 |
p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide.
Topics: Astrocytoma; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regu | 1999 |
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.
Topics: 5' Untranslated Regions; Amyloid beta-Protein Precursor; Astrocytoma; Cell Survival; Chloramphenicol | 2001 |
Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.
Topics: Astrocytoma; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Ac | 2001 |
Mitogen activated protein kinase activation and oxidant signaling in astrocytoma cells.
Topics: Antioxidants; Astrocytoma; Central Nervous System Neoplasms; Cystine; DNA; Enzyme Activation; Enzyme | 2002 |