pd 98059 has been researched along with Asthma in 9 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Montelukast and ketotifen are oral anti-allergy medications in asthmatic children." | 9.12 | Regulation of stromal cell-derived factor-1 and exhaled nitric oxide in asthmatic children following montelukast and ketotifen treatment. ( Chang, HC; Hua, YM; Hung, CH; Jong, YJ; Lai, YS; Li, CY; Yang, KD, 2007) |
| "Montelukast and ketotifen are oral anti-allergy medications in asthmatic children." | 5.12 | Regulation of stromal cell-derived factor-1 and exhaled nitric oxide in asthmatic children following montelukast and ketotifen treatment. ( Chang, HC; Hua, YM; Hung, CH; Jong, YJ; Lai, YS; Li, CY; Yang, KD, 2007) |
| "Vanadium pentoxide (V(2)O(5)) is a cause of occupational asthma and chronic bronchitis, yet the molecular mechanisms through which V(2)O(5) exerts its effects on cell function are unclear." | 3.70 | Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts. ( Bonner, JC; Wang, YZ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, YY | 1 |
| Liu, XS | 1 |
| Liu, C | 1 |
| Xu, YJ | 1 |
| Xiong, WN | 1 |
| Page, K | 1 |
| Hughes, VS | 1 |
| Bennett, GW | 1 |
| Wong, HR | 1 |
| Koch, A | 1 |
| Raidl, M | 1 |
| Lux, M | 1 |
| Müller, K | 1 |
| Büning, H | 1 |
| Humme, S | 1 |
| Erdmann, E | 1 |
| Hung, CH | 1 |
| Jong, YJ | 1 |
| Hua, YM | 1 |
| Li, CY | 1 |
| Lai, YS | 1 |
| Yang, KD | 1 |
| Chang, HC | 1 |
| Hu, CP | 1 |
| Feng, JT | 1 |
| Tang, YL | 1 |
| Zhu, JQ | 1 |
| Lin, MJ | 1 |
| Yu, ME | 1 |
| Tsang, F | 1 |
| Koh, AH | 1 |
| Ting, WL | 1 |
| Wong, PT | 1 |
| Wong, WS | 1 |
| Wang, YZ | 1 |
| Bonner, JC | 1 |
| Hallsworth, MP | 1 |
| Moir, LM | 1 |
| Lai, D | 1 |
| Hirst, SJ | 1 |
| Moore, PE | 1 |
| Church, TL | 1 |
| Chism, DD | 1 |
| Panettieri, RA | 1 |
| Shore, SA | 1 |
1 trial available for pd 98059 and Asthma
| Article | Year |
|---|---|
Regulation of stromal cell-derived factor-1 and exhaled nitric oxide in asthmatic children following montelukast and ketotifen treatment.
Topics: Acetates; Administration, Oral; Adolescent; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Bud | 2007 |
8 other studies available for pd 98059 and Asthma
| Article | Year |
|---|---|
Role of extracellular signal-regulated kinase in regulating expression of interleukin 13 in lymphocytes from an asthmatic rat model.
Topics: Animals; Asthma; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Extrace | 2010 |
German cockroach proteases regulate matrix metalloproteinase-9 in human bronchial epithelial cells.
Topics: Animals; Asthma; Blattellidae; Bronchi; Cell Line, Transformed; Epithelial Cells; Extracellular Sign | 2006 |
IL-12-induced T-bet expression and IFNgamma release in lymphocytes from asthmatics--role of MAPkinases ERK-1/-2, p38(MAPK) and effect of dexamethasone.
Topics: Adult; Asthma; Cells, Cultured; Dexamethasone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; | 2007 |
LIF upregulates expression of NK-1R in NHBE cells.
Topics: Animals; Asthma; Base Sequence; Bronchi; Cells, Cultured; Epithelial Cells; Flavonoids; Humans; Janu | 2006 |
Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro.
Topics: Analysis of Variance; Animals; Asthma; Bronchi; Bronchoconstriction; Dose-Response Relationship, Dru | 1998 |
Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts.
Topics: Acetylcysteine; Animals; Asthma; Bronchitis; Carbon; Coal Ash; Colforsin; Enzyme Activation; ErbB Re | 2000 |
Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Butadienes | 2001 |
IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK.
Topics: Antineoplastic Agents; Asthma; Butadienes; Cells, Cultured; Chemokine CCL11; Chemokines, CC; Enzyme | 2002 |