pd 98059 has been researched along with Arthritis, Rheumatoid in 19 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this research is to study the effect of genistein on cytokines or growth factor-induced proliferation and transformation phenotype of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)." | 7.78 | Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis. ( Dong, J; He, P; Li, N; Li, W; Sun, T; Zhang, Q; Zhang, Y, 2012) |
| "The purpose of this research is to study the effect of genistein on cytokines or growth factor-induced proliferation and transformation phenotype of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)." | 3.78 | Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis. ( Dong, J; He, P; Li, N; Li, W; Sun, T; Zhang, Q; Zhang, Y, 2012) |
| "Melatonin has been shown to have potent anti-proliferative effect in various cancer cells such as breast and prostate cancer cells." | 1.35 | Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21(CIP1)/P27(KIP1) pathways. ( Baik, HH; Cho, HY; Chung, JH; Ha, E; Nah, SS; Park, HJ; Won, HJ, 2009) |
| "Apigenin treatment resulted in activation of the mitogen-activated protein kinase (MAPK) ERK1/2, and pretreatment with an ERK inhibitor PD98059 dramatically reduced apigenin-induced apoptosis." | 1.35 | Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. ( Cho, J; Cho, WS; Jeong, M; Kim, C; Lee, JM; Lee, K; Lee, SG; Shin, GC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 12 (63.16) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, K | 1 |
| Fu, W | 1 |
| Zhao, S | 1 |
| Jiao, T | 1 |
| Wu, D | 1 |
| Wang, Y | 1 |
| Tang, C | 1 |
| Li, Y | 1 |
| Lin, X | 1 |
| Ye, J | 1 |
| Li, W | 2 |
| He, Z | 1 |
| Li, F | 2 |
| Cai, X | 1 |
| Liu, Y | 1 |
| Wang, D | 1 |
| Shi, G | 1 |
| Xing, R | 1 |
| Jin, Y | 1 |
| Sun, L | 1 |
| Yang, L | 1 |
| Li, C | 1 |
| Li, Z | 1 |
| Liu, X | 1 |
| Zhao, J | 1 |
| Hashizume, M | 1 |
| Hayakawa, N | 1 |
| Mihara, M | 1 |
| Gang, C | 1 |
| Jiahui, Y | 1 |
| Huaizhou, W | 1 |
| Qing, C | 1 |
| Dongbao, Z | 1 |
| Qian, S | 1 |
| Nah, SS | 1 |
| Won, HJ | 1 |
| Park, HJ | 1 |
| Ha, E | 1 |
| Chung, JH | 1 |
| Cho, HY | 1 |
| Baik, HH | 1 |
| Shin, GC | 1 |
| Kim, C | 1 |
| Lee, JM | 1 |
| Cho, WS | 1 |
| Lee, SG | 1 |
| Jeong, M | 1 |
| Cho, J | 1 |
| Lee, K | 1 |
| Westra, J | 1 |
| Brouwer, E | 1 |
| Bouwman, E | 1 |
| Doornbos-van der Meer, B | 1 |
| Posthumus, MD | 1 |
| van Leeuwen, MA | 1 |
| Limburg, PC | 1 |
| Ueda, Y | 1 |
| Kallenberg, CG | 1 |
| Zhang, Y | 1 |
| Dong, J | 1 |
| He, P | 1 |
| Zhang, Q | 1 |
| Li, N | 1 |
| Sun, T | 1 |
| Yasuda, T | 1 |
| Shimizu, M | 1 |
| Nakagawa, T | 1 |
| Julovi, SM | 1 |
| Nakamura, T | 1 |
| Hsieh, MS | 1 |
| Ho, HC | 1 |
| Chou, DT | 1 |
| Pan, S | 1 |
| Liang, YC | 1 |
| Hsieh, TY | 1 |
| Lan, JL | 1 |
| Tsai, SH | 1 |
| Kim, KW | 1 |
| Cho, ML | 1 |
| Park, MK | 1 |
| Yoon, CH | 1 |
| Park, SH | 1 |
| Lee, SH | 1 |
| Kim, HY | 1 |
| Wang, CH | 1 |
| Chen, LN | 1 |
| Zhu, P | 1 |
| Fan, CM | 1 |
| Wang, YH | 1 |
| Jia, JF | 1 |
| Li, WQ | 1 |
| Zafarullah, M | 1 |
| Miyazawa, K | 1 |
| Mori, A | 1 |
| Okudaira, H | 1 |
| Vincenti, MP | 1 |
| Brinckerhoff, CE | 1 |
| Neff, L | 1 |
| Zeisel, M | 1 |
| Sibilia, J | 1 |
| Schöller-Guinard, M | 1 |
| Klein, JP | 1 |
| Wachsmann, D | 1 |
| Kitasato, H | 1 |
| Noda, M | 1 |
| Akahoshi, T | 1 |
| Okamoto, R | 1 |
| Koshino, T | 1 |
| Murakami, Y | 1 |
| Inoue, M | 1 |
| Kawai, S | 1 |
19 other studies available for pd 98059 and Arthritis, Rheumatoid
| Article | Year |
|---|---|
miR-483-3p Promotes IL-33 Production from Fibroblast-Like Synoviocytes by Regulating ERK Signaling in Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Cell Line; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoid | 2021 |
Prolactin increases tumor necrosis factor alpha expression in peripheral CD14 monocytes of patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Flavonoids; Gene Expression Regulation; Gene Silencing; Humans; Lipopolysacch | 2014 |
Gαq controls rheumatoid arthritis via regulation of Th17 differentiation.
Topics: Animals; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Dendritic Cells; Flavonoids; Gene Expres | 2015 |
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cadherins; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cul | 2016 |
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Blotting, Western; | 2008 |
Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4(+) and CD8(+) T-cell dysfunction in patients with active SLE.
Topics: Adult; Aged; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Arthritis, Rheumatoid; | 2009 |
Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21(CIP1)/P27(KIP1) pathways.
Topics: Aged; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor | 2009 |
Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes.
Topics: Apigenin; Apoptosis; Arthritis, Rheumatoid; Caspases; Cell Line; Cell Survival; Enzyme Activation; F | 2009 |
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase | 2009 |
Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis.
Topics: Anthracenes; Arthritis, Rheumatoid; Cell Cycle; Cell Proliferation; Cells, Cultured; Epidermal Growt | 2012 |
Matrix metalloproteinase production by COOH-terminal heparin-binding fibronectin fragment in rheumatoid synovial cells.
Topics: Arthritis, Rheumatoid; Carrier Proteins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Fibro | 2003 |
Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages.
Topics: Animals; Arthritis, Gouty; Arthritis, Rheumatoid; Blotting, Western; Enzyme Inhibitors; Enzyme Precu | 2003 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Compl | 2005 |
[CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].
Topics: Adult; Aged; Anthracenes; Arthritis, Rheumatoid; Basigin; Calcium-Calmodulin-Dependent Protein Kinas | 2007 |
Oncostatin M up-regulates tissue inhibitor of metalloproteinases-3 gene expression in articular chondrocytes via de novo transcription, protein synthesis, and tyrosine kinase- and mitogen-activated protein kinase-dependent mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinas | 1998 |
Establishment and characterization of a novel human rheumatoid fibroblast-like synoviocyte line, MH7A, immortalized with SV40 T antigen.
Topics: Antigens, Polyomavirus Transforming; Antigens, Surface; Arthritis, Rheumatoid; Calcium-Calmodulin-De | 1998 |
The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Collagenases; Enzyme Inhibi | 2001 |
NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci.
Topics: Anti-Bacterial Agents; Apigenin; Arthritis, Rheumatoid; Bacterial Proteins; Cells, Cultured; Curcumi | 2001 |
Activated Ras modifies the proliferative response of rheumatoid synovial cells to TNF-alpha and TGF-alpha.
Topics: Apoptosis; Arthritis, Rheumatoid; Blotting, Northern; Cell Division; Cell Survival; Cells, Cultured; | 2001 |