pd 98059 has been researched along with Angiogenesis, Pathologic in 33 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "MKN28 human gastric cancer cells were treated with trypsin, a PAR-2 activator, and subjected to real-time reverse transcription polymerase chain reaction (qRT-PCR), western blotting and ELISA for gene expression analyses." | 1.38 | Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells. ( Gao, GR; Lv, CG; Zhang, BL; Zhang, C; Zhang, XF; Zhang, ZL, 2012) |
| "Human cervical cancer cell lines C-33A and HeLa were transiently cotransfected with pSG5-HPV-16 E6 or 16 E7 constructs along with HIF-1 alpha small interfering RNA (siRNA) or nonspecific siRNA." | 1.34 | Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. ( Brown, J; Le, AD; Nishitani, J; Shi, S; Tang, X; Zhang, Q, 2007) |
| "Release of VEGF from a breast cancer cell line (T47D) was quantitated by enzyme linked immunosorbent assay (ELISA)." | 1.34 | Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells. ( Bingle, L; Corke, KP; Fang, WG; Gong, LH; Shi, YH; Wang, YX, 2007) |
| "However, NSAIDs produce gastroduodenal ulcers in about 25% of users (often with bleeding and/or perforations) and delay ulcer healing, presumably by blocking prostaglandin synthesis from cyclooxygenase (COX)-1 and COX-2 (ref." | 1.30 | Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. ( Itani, RM; Jones, MK; Levin, E; Peskar, BM; Sarfeh, IJ; Tarnawski, AS; Wang, H, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 22 (66.67) | 29.6817 |
| 2010's | 9 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qiu, F | 1 |
| Shi, CH | 1 |
| Zheng, J | 1 |
| Liu, YB | 1 |
| Chang, LH | 1 |
| Pan, SL | 1 |
| Lai, CY | 1 |
| Tsai, AC | 1 |
| Teng, CM | 1 |
| Lee, KH | 1 |
| Koh, SA | 1 |
| Kim, JR | 1 |
| Liu, F | 1 |
| Lin, B | 1 |
| Liu, X | 1 |
| Zhang, W | 1 |
| Zhang, E | 1 |
| Hu, L | 1 |
| Ma, Y | 1 |
| Li, X | 1 |
| Tang, X | 2 |
| Zhou, J | 1 |
| Ni, X | 1 |
| Huang, X | 1 |
| Yao, J | 1 |
| He, Q | 1 |
| Wang, K | 1 |
| Duan, T | 1 |
| Chen, HX | 1 |
| Xu, XX | 1 |
| Tan, BZ | 1 |
| Zhang, Z | 1 |
| Zhou, XD | 1 |
| Hueng, DY | 1 |
| Lin, GJ | 1 |
| Huang, SH | 1 |
| Liu, LW | 1 |
| Ju, DT | 1 |
| Chen, YW | 1 |
| Sytwu, HK | 1 |
| Chang, C | 1 |
| Huang, SM | 1 |
| Yeh, YS | 1 |
| Lee, HM | 1 |
| Ma, HI | 1 |
| Zhang, C | 1 |
| Gao, GR | 1 |
| Lv, CG | 1 |
| Zhang, BL | 1 |
| Zhang, ZL | 1 |
| Zhang, XF | 1 |
| Yang, XJ | 1 |
| Chen, GL | 1 |
| Yu, SC | 1 |
| Xu, C | 1 |
| Xin, YH | 1 |
| Li, TT | 1 |
| Shi, Y | 1 |
| Gu, A | 1 |
| Duan, JJ | 1 |
| Qian, C | 1 |
| Cui, YH | 1 |
| Zhang, X | 1 |
| Bian, XW | 1 |
| Steinle, JJ | 1 |
| Meininger, CJ | 1 |
| Forough, R | 1 |
| Wu, G | 1 |
| Wu, MH | 1 |
| Granger, HJ | 1 |
| Okamoto, T | 1 |
| Yamagishi, S | 1 |
| Inagaki, Y | 1 |
| Amano, S | 1 |
| Takeuchi, M | 1 |
| Kikuchi, S | 1 |
| Ohno, S | 1 |
| Yoshimura, A | 1 |
| Alavi, A | 1 |
| Hood, JD | 1 |
| Frausto, R | 1 |
| Stupack, DG | 1 |
| Cheresh, DA | 1 |
| Mariano-Oliveira, A | 1 |
| Coelho, AL | 1 |
| Terruggi, CH | 1 |
| Selistre-de-Araújo, HS | 1 |
| Barja-Fidalgo, C | 1 |
| De Freitas, MS | 1 |
| Wang, FS | 1 |
| Wang, CJ | 1 |
| Chen, YJ | 1 |
| Chang, PR | 1 |
| Huang, YT | 1 |
| Sun, YC | 1 |
| Huang, HC | 1 |
| Yang, YJ | 1 |
| Yang, KD | 1 |
| Yanamandra, N | 1 |
| Gumidyala, KV | 1 |
| Waldron, KG | 1 |
| Gujrati, M | 1 |
| Olivero, WC | 1 |
| Dinh, DH | 1 |
| Rao, JS | 1 |
| Mohanam, S | 1 |
| Giuliani, N | 1 |
| Lunghi, P | 1 |
| Morandi, F | 1 |
| Colla, S | 1 |
| Bonomini, S | 1 |
| Hojden, M | 1 |
| Rizzoli, V | 1 |
| Bonati, A | 1 |
| Menu, E | 1 |
| Kooijman, R | 1 |
| Van Valckenborgh, E | 1 |
| Asosingh, K | 1 |
| Bakkus, M | 1 |
| Van Camp, B | 1 |
| Vanderkerken, K | 1 |
| Watanabe, D | 1 |
| Takagi, H | 1 |
| Suzuma, K | 1 |
| Suzuma, I | 1 |
| Oh, H | 1 |
| Ohashi, H | 1 |
| Kemmochi, S | 1 |
| Uemura, A | 1 |
| Ojima, T | 1 |
| Suganami, E | 1 |
| Miyamoto, N | 1 |
| Sato, Y | 1 |
| Honda, Y | 1 |
| Zhao, B | 1 |
| Cai, J | 1 |
| Boulton, M | 1 |
| Miura, S | 1 |
| Matsuo, Y | 1 |
| Kawamura, A | 1 |
| Saku, K | 1 |
| He, Z | 1 |
| Opland, DM | 1 |
| Way, KJ | 1 |
| Ueki, K | 1 |
| Bodyak, N | 1 |
| Kang, PM | 1 |
| Izumo, S | 1 |
| Kulkarni, RN | 1 |
| Wang, B | 1 |
| Liao, R | 1 |
| Kahn, CR | 1 |
| King, GL | 1 |
| Mousa, SA | 1 |
| O'Connor, L | 1 |
| Rossman, TG | 1 |
| Block, E | 1 |
| Zhang, Q | 1 |
| Nishitani, J | 1 |
| Brown, J | 1 |
| Shi, S | 1 |
| Le, AD | 1 |
| Wang, CH | 1 |
| Chen, LN | 1 |
| Zhu, P | 1 |
| Fan, CM | 1 |
| Wang, YH | 1 |
| Jia, JF | 1 |
| Shi, YH | 1 |
| Bingle, L | 1 |
| Gong, LH | 1 |
| Wang, YX | 1 |
| Corke, KP | 1 |
| Fang, WG | 1 |
| Zhou, JN | 1 |
| Ljungdahl, S | 1 |
| Shoshan, MC | 1 |
| Swedenborg, J | 1 |
| Linder, S | 1 |
| Jones, MK | 1 |
| Wang, H | 1 |
| Peskar, BM | 1 |
| Levin, E | 1 |
| Itani, RM | 1 |
| Sarfeh, IJ | 1 |
| Tarnawski, AS | 2 |
| Rak, J | 1 |
| Mitsuhashi, Y | 1 |
| Sheehan, C | 1 |
| Tamir, A | 1 |
| Viloria-Petit, A | 1 |
| Filmus, J | 1 |
| Mansour, SJ | 1 |
| Ahn, NG | 1 |
| Kerbel, RS | 1 |
| Okajima, E | 1 |
| Thorgeirsson, UP | 1 |
| Sodhi, A | 1 |
| Montaner, S | 1 |
| Patel, V | 1 |
| Zohar, M | 1 |
| Bais, C | 1 |
| Mesri, EA | 1 |
| Gutkind, JS | 1 |
| Jiménez, B | 1 |
| Volpert, OV | 1 |
| Reiher, F | 1 |
| Chang, L | 1 |
| Muñoz, A | 1 |
| Karin, M | 1 |
| Bouck, N | 1 |
| Pai, R | 1 |
| Szabo, IL | 1 |
| Soreghan, BA | 1 |
| Atay, S | 1 |
| Kawanaka, H | 1 |
| Solorzano, CC | 1 |
| Jung, YD | 1 |
| Bucana, CD | 1 |
| McConkey, DJ | 1 |
| Gallick, GE | 1 |
| McMahon, G | 1 |
| Ellis, LM | 1 |
33 other studies available for pd 98059 and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Periostin mediates the increased pro-angiogenic activity of gastric cancer cells under hypoxic conditions.
Topics: Cell Adhesion Molecules; Cell Communication; Cell Hypoxia; Cell Line, Tumor; Coculture Techniques; F | 2013 |
Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-A-mediated angiogenesis.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Down-Regulation; Flavonoids; Humans; | 2013 |
Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells.
Topics: Adenocarcinoma; Base Sequence; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavono | 2013 |
ERK Signaling Pathway Is Involved in HPV-16 E6 but not E7 Oncoprotein-Induced HIF-1α Protein Accumulation in NSCLC Cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Flavonoids; Gene Expression Regulation, Neoplastic | 2016 |
Potential Role of Hyperglycemia in Fetoplacental Endothelial Dysfunction in Gestational Diabetes Mellitus.
Topics: Adult; Case-Control Studies; Cell Movement; Cell Proliferation; Diabetes, Gestational; Diffusion Cha | 2016 |
MicroRNA-29b Inhibits Angiogenesis by Targeting VEGFA through the MAPK/ERK and PI3K/Akt Signaling Pathways in Endometrial Carcinoma.
Topics: Androstadienes; Animals; Cell Line, Tumor; Endometrial Neoplasms; Female; Flavonoids; Gene Expressio | 2017 |
Inhibition of Nodal suppresses angiogenesis and growth of human gliomas.
Topics: Analysis of Variance; Animals; Benzamides; Brain Neoplasms; Cell Line, Transformed; Cell Proliferati | 2011 |
Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells.
Topics: Cell Line, Tumor; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; | 2012 |
TGF-β1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Anthracenes; Cell Line, Tumor; Cell | 2013 |
Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway.
Topics: Alkaloids; Azepines; Blotting, Western; Calcium; Carbazoles; Cell Division; Cell Movement; Cells, Cu | 2002 |
Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro.
Topics: Animals; Cells, Cultured; Diphosphonates; Endothelial Growth Factors; Endothelium, Vascular; Flavono | 2002 |
Role of Raf in vascular protection from distinct apoptotic stimuli.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Chick Embryo; Endothelial Growth Factors; Endoth | 2003 |
Alternagin-C, a nonRGD-disintegrin, induces neutrophil migration via integrin signaling.
Topics: Actins; Active Transport, Cell Nucleus; Amino Acid Motifs; Animals; Bothrops; Cell Movement; Cell Nu | 2003 |
Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts.
Topics: Cell Differentiation; Cell Division; Cell Nucleus; Cells, Cultured; Cytosol; Dinoprostone; Electric | 2004 |
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; | 2004 |
Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis.
Topics: Cell Division; Down-Regulation; Flavonoids; Humans; Interleukin-6; MAP Kinase Kinase 1; Mitogen-Acti | 2004 |
Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.
Topics: Animals; Cell Division; Cell Movement; Chemotaxis; Disease Models, Animal; Down-Regulation; Flavonoi | 2004 |
Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.
Topics: Adenoviridae; Angiopoietin-2; Animals; Blotting, Northern; Blotting, Western; Butadienes; Carbazoles | 2004 |
Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2.
Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Flavo | 2004 |
JTT-705 blocks cell proliferation and angiogenesis through p38 kinase/p27(kip1) and Ras/p21(waf1) pathways.
Topics: Amides; Atherosclerosis; Cell Division; Cells, Cultured; Coronary Vessels; Cyclin-Dependent Kinase I | 2005 |
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Topics: Androstadienes; Animals; Cells, Cultured; Coronary Vessels; Flavonoids; Humans; Insulin; Insulin Res | 2006 |
Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds.
Topics: Angiogenesis Inducing Agents; Animals; Arsenites; Chick Embryo; Chorioallantoic Membrane; Fibroblast | 2007 |
Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.
Topics: Anticarcinogenic Agents; Carcinoma; Chromones; Female; Flavonoids; HeLa Cells; Humans; Hypoxia-Induc | 2007 |
[CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].
Topics: Adult; Aged; Anthracenes; Arthritis, Rheumatoid; Basigin; Calcium-Calmodulin-Dependent Protein Kinas | 2007 |
Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells.
Topics: Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Extracellular Signal | 2007 |
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactin | 1998 |
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase | 1999 |
Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chromones; Endothelia | 2000 |
Different regulation of vascular endothelial growth factor expression by the ERK and p38 kinase pathways in v-ras, v-raf, and v-myc transformed cells.
Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma; Cell Line; Cell | 2000 |
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; DNA-Binding Proteins; E | 2000 |
c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Capillaries; CD36 Antigens; Cells, Cultured; Cornea; Cy | 2001 |
PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways.
Topics: Animals; Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Dinoprostone; Dose-Response | 2001 |
In vivo intracellular signaling as a marker of antiangiogenic activity.
Topics: Androstadienes; Angiogenesis Inhibitors; Biomarkers, Tumor; Blotting, Western; Endothelial Growth Fa | 2001 |