pd 98059 has been researched along with Anaplastic Astrocytoma in 9 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 7.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 3.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "Phenserine treatment resulted in decreased secretion of soluble betaAPP and Abeta into the conditioned media of human neuroblastoma cells without cellular toxicity." | 1.31 | Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. ( Brossi, A; Ge, YW; Greig, NH; Lahiri, DK; Rogers, J; Sambamurti, K; Shaw, KT; Utsuki, T; Yu, QS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, MS | 1 |
| Jo, H | 1 |
| Um, JY | 1 |
| Yi, JM | 1 |
| Kim, DK | 1 |
| Choi, SC | 1 |
| Kim, TH | 1 |
| Nah, YH | 1 |
| Kim, HM | 1 |
| Lee, YM | 1 |
| Zaheer, A | 1 |
| Sahu, SK | 1 |
| Ryken, TC | 1 |
| Traynelis, VC | 1 |
| Belsey, MJ | 1 |
| Davies, AR | 1 |
| Witchel, HJ | 1 |
| Kozlowski, RZ | 1 |
| Kambe, A | 1 |
| Iguchi, G | 1 |
| Moon, Y | 1 |
| Kamitani, H | 1 |
| Watanabe, T | 1 |
| Eling, TE | 1 |
| Luo, W | 1 |
| Sharif, TR | 1 |
| Sharif, M | 1 |
| Navarro, L | 1 |
| David, M | 1 |
| Shaw, KT | 1 |
| Utsuki, T | 1 |
| Rogers, J | 1 |
| Yu, QS | 1 |
| Sambamurti, K | 1 |
| Brossi, A | 1 |
| Ge, YW | 1 |
| Lahiri, DK | 1 |
| Greig, NH | 1 |
| Hernández-Angeles, A | 1 |
| Soria-Jasso, LE | 1 |
| Ortega, A | 1 |
| Arias-Montaño, JA | 1 |
| Kuruganti, PA | 1 |
| Wurster, RD | 1 |
| Lucchesi, PA | 1 |
9 other studies available for pd 98059 and Anaplastic Astrocytoma
| Article | Year |
|---|---|
Agonists of proteinase-activated receptor 2 induce TNF-alpha secretion from astrocytoma cells.
Topics: Astrocytoma; Blotting, Western; Calcium; Central Nervous System; Chymases; Cytokines; Enzyme Activat | 2002 |
Cis-parinaric acid effects, cytotoxicity, c-Jun N-terminal protein kinase, forkhead transcription factor and Mn-SOD differentially in malignant and normal astrocytes.
Topics: Animals; Astrocytes; Astrocytoma; Cell Line, Tumor; Cell Survival; Curcumin; Fatty Acids, Unsaturate | 2007 |
Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anthracenes; Apoptosis; Astrocytoma; Cell | 2007 |
Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.
Topics: Antineoplastic Agents; Astrocytoma; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; | 2008 |
Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway.
Topics: Amino Acid Sequence; Animals; Astrocytoma; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein | 1996 |
p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide.
Topics: Astrocytoma; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regu | 1999 |
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.
Topics: 5' Untranslated Regions; Amyloid beta-Protein Precursor; Astrocytoma; Cell Survival; Chloramphenicol | 2001 |
Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.
Topics: Astrocytoma; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Ac | 2001 |
Mitogen activated protein kinase activation and oxidant signaling in astrocytoma cells.
Topics: Antioxidants; Astrocytoma; Central Nervous System Neoplasms; Cystine; DNA; Enzyme Activation; Enzyme | 2002 |