pd 98059 has been researched along with Aging in 17 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Elastin is a long-lived protein and a key component of connective tissues." | 1.40 | 4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts. ( Grazide, MH; Josse, G; Larroque-Cardoso, P; Mucher, E; Nadal-Wolbold, F; Nègre-Salvayre, A; Salvayre, R; Schmitt, AM; Zarkovic, K, 2014) |
| "Treatment with wortmannin or p85alpha siRNA reduced pancreatic regeneration after partial Px." | 1.33 | Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. ( Evers, BM; Rychahou, PG; Saito, H; Uchida, T; Watanabe, H, 2005) |
| " Three different treatment paradigms were used: a single application of GM1 to brain slices in situ, a single intracerebroventricular (icv) administration of GM1 in vivo, and chronic administration of GM1 in vivo." | 1.33 | GM1 and ERK signaling in the aged brain. ( Duchemin, AM; Hadjiconstantinou, M; Mo, L; Neff, NH; Ren, Q, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 12 (70.59) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Larroque-Cardoso, P | 1 |
| Mucher, E | 1 |
| Grazide, MH | 1 |
| Josse, G | 1 |
| Schmitt, AM | 1 |
| Nadal-Wolbold, F | 1 |
| Zarkovic, K | 1 |
| Salvayre, R | 1 |
| Nègre-Salvayre, A | 1 |
| Kim, W | 1 |
| Kim, E | 1 |
| Yang, HJ | 1 |
| Kwon, T | 1 |
| Han, S | 1 |
| Lee, S | 1 |
| Youn, H | 1 |
| Jung, Y | 1 |
| Kang, C | 1 |
| Youn, B | 1 |
| Wu, H | 1 |
| Zhao, J | 1 |
| Chen, M | 1 |
| Wang, H | 1 |
| Yao, Q | 1 |
| Fan, J | 1 |
| Zhang, M | 1 |
| Dupont, E | 1 |
| Stevens, L | 1 |
| Cochon, L | 1 |
| Falempin, M | 1 |
| Bastide, B | 1 |
| Canu, MH | 1 |
| Gennaro, G | 1 |
| Ménard, C | 1 |
| Giasson, E | 1 |
| Michaud, SE | 1 |
| Palasis, M | 1 |
| Meloche, S | 1 |
| Rivard, A | 1 |
| Xiao, ZQ | 1 |
| Li, J | 1 |
| Majumdar, AP | 1 |
| Tortorella, C | 2 |
| Stella, I | 2 |
| Piazzolla, G | 2 |
| Simone, O | 2 |
| Cappiello, V | 2 |
| Antonaci, S | 2 |
| Watanabe, H | 1 |
| Saito, H | 1 |
| Rychahou, PG | 1 |
| Uchida, T | 1 |
| Evers, BM | 1 |
| Diaz, ES | 1 |
| Pellizzari, E | 1 |
| Casanova, M | 1 |
| Cigorraga, SB | 1 |
| Denduchis, B | 1 |
| Mo, L | 1 |
| Ren, Q | 1 |
| Duchemin, AM | 1 |
| Neff, NH | 1 |
| Hadjiconstantinou, M | 1 |
| Lee, TJ | 1 |
| Lee, JT | 1 |
| Moon, SK | 1 |
| Kim, CH | 1 |
| Park, JW | 1 |
| Kwon, TK | 1 |
| McGahon, B | 1 |
| Maguire, C | 1 |
| Kelly, A | 1 |
| Lynch, MA | 1 |
| Dardevet, D | 1 |
| Sornet, C | 1 |
| Balage, M | 1 |
| Grizard, J | 1 |
| Ikeyama, S | 1 |
| Kokkonen, G | 1 |
| Shack, S | 1 |
| Wang, XT | 1 |
| Holbrook, NJ | 1 |
| Srinivasan, S | 1 |
| Strange, J | 1 |
| Awonusonu, F | 1 |
| Bruce, MC | 1 |
| Molero, JC | 1 |
| Pérez, C | 1 |
| Martínez, C | 1 |
| Villar, M | 1 |
| Andrés, A | 1 |
| Fermín, Y | 1 |
| Carrascosa, JM | 1 |
17 other studies available for pd 98059 and Aging
| Article | Year |
|---|---|
4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts.
Topics: Adult; Aging; Aldehydes; Animals; Aorta; Cell Line, Transformed; Elastin; ErbB Receptors; Fibroblast | 2014 |
Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing.
Topics: Aging; Anilides; Animals; Cell Line; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Flav | 2015 |
The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats.
Topics: Aging; Animals; Erythropoietin; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; | 2017 |
ERK is involved in the reorganization of somatosensory cortical maps in adult rats submitted to hindlimb unloading.
Topics: Aging; Animals; Enzyme Activation; Flavonoids; Hindlimb Suspension; Male; Mitogen-Activated Protein | 2011 |
Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation.
Topics: Age Factors; Aging; Animals; Aorta; Apoptosis; Arteriosclerosis; Catheterization; Cell Division; Cel | 2003 |
Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.
Topics: Aging; Animals; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Gastric Mucos | 2003 |
Role of defective ERK phosphorylation in the impaired GM-CSF-induced oxidative response of neutrophils in elderly humans.
Topics: Aged; Aging; Blotting, Western; Cell Separation; Enzyme Inhibitors; Female; Flavonoids; Granulocyte- | 2004 |
Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.
Topics: Aging; Androstadienes; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Male; | 2005 |
Type IV collagen induces down-regulation of steroidogenic response to gonadotropins in adult rat Leydig cells involving mitogen-activated protein kinase.
Topics: Aging; Animals; Cells, Cultured; Chorionic Gonadotropin; Collagen Type IV; Cyclic AMP; Down-Regulati | 2005 |
GM1 and ERK signaling in the aged brain.
Topics: Age Factors; Aging; Animals; Blotting, Western; Brain; Drug Administration Routes; Drug Administrati | 2005 |
Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells.
Topics: Acetylcysteine; Age Factors; Aging; Aldehydes; Animals; Aorta; Cell Cycle; Cell Death; Cell Prolifer | 2006 |
Role of phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways in granulocyte macrophage-colony-stimulating factor failure to delay fas-induced neutrophil apoptosis in elderly humans.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antibodies, Monoclonal; Apoptosis; Case-Control Studies; Cell | 2006 |
Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes.
Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Drug Synergism; Electric Stimulation; | 1999 |
Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age.
Topics: Aging; Amino Acids; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Leu | 2000 |
Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities.
Topics: Aging; Animals; Cell Survival; Cells, Cultured; Chromones; Drug Synergism; Energy Intake; Enzyme Inh | 2002 |
Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Cell Membrane; Cell Survival; Cells, Cultured; Chromone | 2002 |
Activation of MAP kinase by insulin and vanadate in adipocytes from young and old rats.
Topics: Adipocytes; Aging; Androstadienes; Animals; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Male; MA | 2002 |