Page last updated: 2024-11-02

pd 98059 and Aging

pd 98059 has been researched along with Aging in 17 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Elastin is a long-lived protein and a key component of connective tissues."1.404-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts. ( Grazide, MH; Josse, G; Larroque-Cardoso, P; Mucher, E; Nadal-Wolbold, F; Nègre-Salvayre, A; Salvayre, R; Schmitt, AM; Zarkovic, K, 2014)
"Treatment with wortmannin or p85alpha siRNA reduced pancreatic regeneration after partial Px."1.33Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. ( Evers, BM; Rychahou, PG; Saito, H; Uchida, T; Watanabe, H, 2005)
" Three different treatment paradigms were used: a single application of GM1 to brain slices in situ, a single intracerebroventricular (icv) administration of GM1 in vivo, and chronic administration of GM1 in vivo."1.33GM1 and ERK signaling in the aged brain. ( Duchemin, AM; Hadjiconstantinou, M; Mo, L; Neff, NH; Ren, Q, 2005)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's12 (70.59)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Larroque-Cardoso, P1
Mucher, E1
Grazide, MH1
Josse, G1
Schmitt, AM1
Nadal-Wolbold, F1
Zarkovic, K1
Salvayre, R1
Nègre-Salvayre, A1
Kim, W1
Kim, E1
Yang, HJ1
Kwon, T1
Han, S1
Lee, S1
Youn, H1
Jung, Y1
Kang, C1
Youn, B1
Wu, H1
Zhao, J1
Chen, M1
Wang, H1
Yao, Q1
Fan, J1
Zhang, M1
Dupont, E1
Stevens, L1
Cochon, L1
Falempin, M1
Bastide, B1
Canu, MH1
Gennaro, G1
Ménard, C1
Giasson, E1
Michaud, SE1
Palasis, M1
Meloche, S1
Rivard, A1
Xiao, ZQ1
Li, J1
Majumdar, AP1
Tortorella, C2
Stella, I2
Piazzolla, G2
Simone, O2
Cappiello, V2
Antonaci, S2
Watanabe, H1
Saito, H1
Rychahou, PG1
Uchida, T1
Evers, BM1
Diaz, ES1
Pellizzari, E1
Casanova, M1
Cigorraga, SB1
Denduchis, B1
Mo, L1
Ren, Q1
Duchemin, AM1
Neff, NH1
Hadjiconstantinou, M1
Lee, TJ1
Lee, JT1
Moon, SK1
Kim, CH1
Park, JW1
Kwon, TK1
McGahon, B1
Maguire, C1
Kelly, A1
Lynch, MA1
Dardevet, D1
Sornet, C1
Balage, M1
Grizard, J1
Ikeyama, S1
Kokkonen, G1
Shack, S1
Wang, XT1
Holbrook, NJ1
Srinivasan, S1
Strange, J1
Awonusonu, F1
Bruce, MC1
Molero, JC1
Pérez, C1
Martínez, C1
Villar, M1
Andrés, A1
Fermín, Y1
Carrascosa, JM1

Other Studies

17 other studies available for pd 98059 and Aging

ArticleYear
4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts.
    Free radical biology & medicine, 2014, Volume: 71

    Topics: Adult; Aging; Aldehydes; Animals; Aorta; Cell Line, Transformed; Elastin; ErbB Receptors; Fibroblast

2014
Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing.
    Experimental dermatology, 2015, Volume: 24, Issue:8

    Topics: Aging; Anilides; Animals; Cell Line; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Flav

2015
The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats.
    Journal of molecular neuroscience : MN, 2017, Volume: 61, Issue:3

    Topics: Aging; Animals; Erythropoietin; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus;

2017
ERK is involved in the reorganization of somatosensory cortical maps in adult rats submitted to hindlimb unloading.
    PloS one, 2011, Mar-08, Volume: 6, Issue:3

    Topics: Aging; Animals; Enzyme Activation; Flavonoids; Hindlimb Suspension; Male; Mitogen-Activated Protein

2011
Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Feb-01, Volume: 23, Issue:2

    Topics: Age Factors; Aging; Animals; Aorta; Apoptosis; Arteriosclerosis; Catheterization; Cell Division; Cel

2003
Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:2

    Topics: Aging; Animals; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Gastric Mucos

2003
Role of defective ERK phosphorylation in the impaired GM-CSF-induced oxidative response of neutrophils in elderly humans.
    Mechanisms of ageing and development, 2004, Volume: 125, Issue:8

    Topics: Aged; Aging; Blotting, Western; Cell Separation; Enzyme Inhibitors; Female; Flavonoids; Granulocyte-

2004
Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.
    Gastroenterology, 2005, Volume: 128, Issue:5

    Topics: Aging; Androstadienes; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Male;

2005
Type IV collagen induces down-regulation of steroidogenic response to gonadotropins in adult rat Leydig cells involving mitogen-activated protein kinase.
    Molecular reproduction and development, 2005, Volume: 72, Issue:2

    Topics: Aging; Animals; Cells, Cultured; Chorionic Gonadotropin; Collagen Type IV; Cyclic AMP; Down-Regulati

2005
GM1 and ERK signaling in the aged brain.
    Brain research, 2005, Aug-30, Volume: 1054, Issue:2

    Topics: Age Factors; Aging; Animals; Blotting, Western; Brain; Drug Administration Routes; Drug Administrati

2005
Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells.
    International journal of molecular medicine, 2006, Volume: 17, Issue:1

    Topics: Acetylcysteine; Age Factors; Aging; Aldehydes; Animals; Aorta; Cell Cycle; Cell Death; Cell Prolifer

2006
Role of phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways in granulocyte macrophage-colony-stimulating factor failure to delay fas-induced neutrophil apoptosis in elderly humans.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Aging; Antibodies, Monoclonal; Apoptosis; Case-Control Studies; Cell

2006
Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes.
    Neuroscience, 1999, Volume: 90, Issue:4

    Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Drug Synergism; Electric Stimulation;

1999
Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age.
    The Journal of nutrition, 2000, Volume: 130, Issue:11

    Topics: Aging; Amino Acids; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Leu

2000
Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:1

    Topics: Aging; Animals; Cell Survival; Cells, Cultured; Chromones; Drug Synergism; Energy Intake; Enzyme Inh

2002
Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Apoptosis; Cell Membrane; Cell Survival; Cells, Cultured; Chromone

2002
Activation of MAP kinase by insulin and vanadate in adipocytes from young and old rats.
    Molecular and cellular endocrinology, 2002, Mar-28, Volume: 189, Issue:1-2

    Topics: Adipocytes; Aging; Androstadienes; Animals; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Male; MA

2002