pd 98059 has been researched along with Adrenal Cancer in 6 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a previous study, we show that stimulation of chemotaxis in rat pheochromocytoma PC12 cells by nerve growth factor (NGF) and epidermal growth factor (EGF) requires activation of the RAS-ERK signaling pathway." | 3.73 | Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells. ( Chan, BM; Ho, WC; Morris, VL; Uniyal, S; Zhou, H, 2005) |
| "Prosaposin treatment induced pheochromocytoma cells (PC12) to enter the S phase of the cell cycle; this effect was inhibited by the MEK inhibitor PD98059, indicating that prosaposin-induced ERK phosphorylation is required for stimulation of DNA synthesis." | 1.31 | Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase. ( Campana, WM; Cifone, MG; Di Marzio , L; Misasi, R; Molinari, S; O'Brien, JS; Pavan, A; Pontieri, GM; Sorice, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, HW | 1 |
| Huang, CY | 1 |
| Yang, SY | 1 |
| Wu, VC | 1 |
| Chu, TS | 1 |
| Chen, YM | 1 |
| Hsieh, BS | 1 |
| Wu, KD | 1 |
| Luo, P | 1 |
| Zhao, Y | 1 |
| Li, D | 1 |
| Chen, T | 1 |
| Li, S | 1 |
| Chao, X | 1 |
| Liu, W | 1 |
| Zhang, L | 1 |
| Qu, Y | 1 |
| Jiang, X | 1 |
| Lu, G | 1 |
| Poon, W | 1 |
| Fei, Z | 1 |
| Cerioni, L | 1 |
| Palomba, L | 1 |
| Cantoni, O | 1 |
| Ho, WC | 1 |
| Uniyal, S | 1 |
| Zhou, H | 1 |
| Morris, VL | 1 |
| Chan, BM | 1 |
| Misasi, R | 1 |
| Sorice, M | 1 |
| Di Marzio , L | 1 |
| Campana, WM | 1 |
| Molinari, S | 1 |
| Cifone, MG | 1 |
| Pavan, A | 1 |
| Pontieri, GM | 1 |
| O'Brien, JS | 1 |
| Yip, PM | 1 |
| Siu, CH | 1 |
6 other studies available for pd 98059 and Adrenal Cancer
| Article | Year |
|---|---|
Role of D2 dopamine receptor in adrenal cortical cell proliferation and aldosterone-producing adenoma tumorigenesis.
Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Aldosterone; Carcinogenesis; Cell Cycle; Cell Prol | 2014 |
Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways.
Topics: Adrenal Gland Neoplasms; Animals; Anthracenes; Apoptosis; Brain-Derived Neurotrophic Factor; Carrier | 2012 |
The Raf/MEK inhibitor PD98059 enhances ERK1/2 phosphorylation mediated by peroxynitrite via enforced mitochondrial formation of reactive oxygen species.
Topics: Adrenal Gland Neoplasms; Animals; Enzyme Inhibitors; Flavonoids; Kinetics; Mitochondria; Mitogen-Act | 2003 |
Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Movement; Cell Proliferation; Chemotaxis; Chromones; Differen | 2005 |
Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase.
Topics: Adrenal Gland Neoplasms; Animals; Apoptosis; Cell Cycle; DNA, Neoplasm; Enzyme Activation; Enzyme In | 2001 |
PC12 cells utilize the homophilic binding site of L1 for cell-cell adhesion but L1-alphavbeta3 interaction for neurite outgrowth.
Topics: Adrenal Gland Neoplasms; Animals; Cell Adhesion; Cell Aggregation; Enzyme Inhibitors; Flavonoids; Hu | 2001 |