pd 98059 has been researched along with Acute Confusional Senile Dementia in 16 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from necropsies of Alzheimer disease (AD) patients shows that there is a change in the pattern of expression and a redistribution of receptors in these brain areas when compared with samples from controls." | 7.72 | A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. ( Angulo, E; Canela, EI; Casadó, V; Ferrer, I; Franco, R; Lluis, C; Mallol, J; Viñals, F, 2003) |
| "Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from necropsies of Alzheimer disease (AD) patients shows that there is a change in the pattern of expression and a redistribution of receptors in these brain areas when compared with samples from controls." | 3.72 | A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. ( Angulo, E; Canela, EI; Casadó, V; Ferrer, I; Franco, R; Lluis, C; Mallol, J; Viñals, F, 2003) |
| "Lithium also blocks the Alzheimer's disease-like proline-directed hyperphosphorylation of tau protein which is observed in neurons treated with a phosphatase inhibitor." | 1.30 | Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons. ( Avila, J; Diaz-Nido, J; Moreno, FJ; Muñoz-Montaño, JR, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 9 (56.25) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jalilzad, M | 1 |
| Jafari, A | 1 |
| Babaei, P | 1 |
| Feld, M | 1 |
| Krawczyk, MC | 1 |
| Sol Fustiñana, M | 1 |
| Blake, MG | 1 |
| Baratti, CM | 1 |
| Romano, A | 1 |
| Boccia, MM | 1 |
| Gan, X | 1 |
| Wu, L | 1 |
| Huang, S | 1 |
| Zhong, C | 1 |
| Shi, H | 1 |
| Li, G | 1 |
| Yu, H | 1 |
| Howard Swerdlow, R | 1 |
| Xi Chen, J | 1 |
| Yan, SS | 1 |
| Wan, Z | 1 |
| Mah, D | 1 |
| Simtchouk, S | 1 |
| Kluftinger, A | 1 |
| Little, JP | 1 |
| Hashimoto, Y | 1 |
| Niikura, T | 1 |
| Chiba, T | 1 |
| Tsukamoto, E | 1 |
| Kadowaki, H | 1 |
| Nishitoh, H | 1 |
| Yamagishi, Y | 1 |
| Ishizaka, M | 1 |
| Yamada, M | 1 |
| Nawa, M | 1 |
| Terashita, K | 1 |
| Aiso, S | 1 |
| Ichijo, H | 1 |
| Nishimoto, I | 1 |
| Angulo, E | 1 |
| Casadó, V | 1 |
| Mallol, J | 1 |
| Canela, EI | 1 |
| Viñals, F | 1 |
| Ferrer, I | 1 |
| Lluis, C | 1 |
| Franco, R | 1 |
| Frasca, G | 1 |
| Chiechio, S | 1 |
| Vancheri, C | 1 |
| Nicoletti, F | 1 |
| Copani, A | 1 |
| Angela Sortino, M | 1 |
| Quintanilla, RA | 1 |
| Orellana, DI | 1 |
| González-Billault, C | 1 |
| Maccioni, RB | 1 |
| Sze, CI | 1 |
| Su, M | 1 |
| Pugazhenthi, S | 1 |
| Jambal, P | 1 |
| Hsu, LJ | 1 |
| Heath, J | 1 |
| Schultz, L | 1 |
| Chang, NS | 1 |
| Urbanelli, L | 1 |
| Emiliani, C | 1 |
| Massini, C | 1 |
| Persichetti, E | 1 |
| Orlacchio, A | 2 |
| Pelicci, G | 1 |
| Sorbi, S | 1 |
| Hasilik, A | 1 |
| Bernardi, G | 1 |
| Muñoz-Montaño, JR | 1 |
| Moreno, FJ | 1 |
| Avila, J | 1 |
| Diaz-Nido, J | 1 |
| Mills, J | 1 |
| Laurent Charest, D | 1 |
| Lam, F | 1 |
| Beyreuther, K | 1 |
| Ida, N | 1 |
| Pelech, SL | 1 |
| Reiner, PB | 1 |
| Ekinci, FJ | 1 |
| Shea, TB | 1 |
| Chong, YH | 1 |
| Sung, JH | 1 |
| Shin, SA | 1 |
| Chung, JH | 1 |
| Suh, YH | 1 |
| Baskys, A | 1 |
| Adamchik, Y | 1 |
| Kim, C | 1 |
| Jang, CH | 1 |
| Bang, JH | 1 |
| Jung, MW | 1 |
| Joo, I | 1 |
| Kim, SU | 1 |
| Mook-Jung, I | 1 |
16 other studies available for pd 98059 and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Neuregulin1β improves both spatial and associative learning and memory in Alzheimer model of rats possibly through signaling pathways other than Erk1/2.
Topics: Alzheimer Disease; Animals; Association Learning; Disease Models, Animal; Flavonoids; Male; MAP Kina | 2019 |
Decrease of ERK/MAPK overactivation in prefrontal cortex reverses early memory deficit in a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Electrophore | 2014 |
Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction.
Topics: Aged; Alzheimer Disease; Cells, Cultured; Cognition; Cognitive Dysfunction; Enzyme Activation; Extra | 2014 |
Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells.
Topics: Adipose Tissue; Alzheimer Disease; Anthracenes; Cell Line, Tumor; Cell Survival; Chromones; Culture | 2015 |
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; An | 2003 |
A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Aged; Alzheimer Diseas | 2003 |
Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: correlation with the MAP kinase pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Different | 2004 |
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway.
Topics: Alzheimer Disease; Animals; Cell Culture Techniques; Cell Survival; DNA Primers; Enzyme Inhibitors; | 2004 |
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anisomycin; Anthracenes; Brain; Cell Line; Cell Line, Tumor; COS Cells; | 2004 |
Cathepsin D expression is decreased in Alzheimer's disease fibroblasts.
Topics: Adult; Alzheimer Disease; Cathepsin D; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Female; | 2008 |
Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.
Topics: Alzheimer Disease; Animals; Blotting, Western; Brain; Calcium-Calmodulin-Dependent Protein Kinases; | 1997 |
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium-Calmoduli | 1997 |
Hyperactivation of mitogen-activated protein kinase increases phospho-tau immunoreactivity within human neuroblastoma: additive and synergistic influence of alteration of additional kinase activities.
Topics: Alzheimer Disease; Androstadienes; Brain; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; | 1999 |
Effects of the beta-amyloid and carboxyl-terminal fragment of Alzheimer's amyloid precursor protein on the production of the tumor necrosis factor-alpha and matrix metalloproteinase-9 by human monocytic THP-1.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Antibodies; Cell Line; Dru | 2001 |
Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Androstadienes; Animals; Cell Death; Culture Media, Serum- | 2001 |
Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Astrocytes; Brain; Cells, | 2002 |