pd 98059 has been researched along with AIDS Dementia Complex in 3 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Neurotoxic factors produced from activated macrophage or microglial cells such as tumor necrosis factor-alpha (TNFalpha), gp120 and quinolinic acid have been implicated as agents for the cell death which often appears to occur by an apoptotic mechanism." | 3.71 | CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation. ( Flitter, WD; Garland, WA; Irwin, I; Kusdra, L; Pulliam, L; Rempel, H, 2001) |
| " In a cell-based model, sunitinib reduced CDK5 phosphorylation (pCDK5), calpain-dependent p35/p25 conversion and protected neuronal cells from the toxic effects of gp120." | 1.40 | Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. ( Crews, LA; Gonzales, T; Kouznetsova, VL; Masliah, E; Overk, CR; Patrick, C; Paulino, A; Price, D; Rockenstein, E; Stocking, E; Tsigelny, IF; Wrasidlo, W, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wrasidlo, W | 1 |
| Crews, LA | 1 |
| Tsigelny, IF | 1 |
| Stocking, E | 1 |
| Kouznetsova, VL | 1 |
| Price, D | 1 |
| Paulino, A | 1 |
| Gonzales, T | 1 |
| Overk, CR | 1 |
| Patrick, C | 1 |
| Rockenstein, E | 1 |
| Masliah, E | 1 |
| Yang, B | 1 |
| Akhter, S | 1 |
| Chaudhuri, A | 1 |
| Kanmogne, GD | 1 |
| Pulliam, L | 1 |
| Irwin, I | 1 |
| Kusdra, L | 1 |
| Rempel, H | 1 |
| Flitter, WD | 1 |
| Garland, WA | 1 |
3 other studies available for pd 98059 and AIDS Dementia Complex
| Article | Year |
|---|---|
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.
Topics: AIDS Dementia Complex; Animals; Antineoplastic Agents; Cyclin-Dependent Kinase 5; Dasatinib; Erlotin | 2014 |
HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling.
Topics: AIDS Dementia Complex; Blood-Brain Barrier; Brain; Cell Adhesion; Cell Movement; Cells, Cultured; Ch | 2009 |
CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation.
Topics: AIDS Dementia Complex; Apoptosis; Brain; Butanes; Cells, Cultured; Culture Media, Conditioned; Enzym | 2001 |