pd-404182 and Anthrax

pd-404182 has been researched along with Anthrax* in 1 studies

Other Studies

1 other study(ies) available for pd-404182 and Anthrax

Article	Year
Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14 Here, we report the results of a quantitative high-throughput screen (qHTS) measuring the endocytosis and translocation of a beta-lactamase-fused-lethal factor and the identification of small molecules capable of obstructing the process of anthrax toxin internalization. Several small molecules protect RAW264.7 macrophages and CHO cells from anthrax lethal toxin and protected cells from an LF-Pseudomonas exotoxin fusion protein and diphtheria toxin. Further efforts demonstrated that these compounds impaired the PA heptamer pre-pore to pore conversion in cells expressing the CMG2 receptor, but not the related TEM8 receptor, indicating that these compounds likely interfere with toxin internalization. Topics: Animals; Anthrax; Anti-Bacterial Agents; Antigens, Bacterial; Bacillus anthracis; Bacterial Proteins; Bacterial Toxins; Cell Death; CHO Cells; Corynebacterium diphtheriae; Cricetinae; Cricetulus; Diphtheria Toxin; Endocytosis; Exotoxins; Macrophages; Mice; Pseudomonas; Small Molecule Libraries	2009

Article

Year

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.

Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14

Here, we report the results of a quantitative high-throughput screen (qHTS) measuring the endocytosis and translocation of a beta-lactamase-fused-lethal factor and the identification of small molecules capable of obstructing the process of anthrax toxin internalization. Several small molecules protect RAW264.7 macrophages and CHO cells from anthrax lethal toxin and protected cells from an LF-Pseudomonas exotoxin fusion protein and diphtheria toxin. Further efforts demonstrated that these compounds impaired the PA heptamer pre-pore to pore conversion in cells expressing the CMG2 receptor, but not the related TEM8 receptor, indicating that these compounds likely interfere with toxin internalization.

Topics: Animals; Anthrax; Anti-Bacterial Agents; Antigens, Bacterial; Bacillus anthracis; Bacterial Proteins; Bacterial Toxins; Cell Death; CHO Cells; Corynebacterium diphtheriae; Cricetinae; Cricetulus; Diphtheria Toxin; Endocytosis; Exotoxins; Macrophages; Mice; Pseudomonas; Small Molecule Libraries

2009