pd-173212 and Seizures

pd-173212 has been researched along with Seizures* in 1 studies

Other Studies

1 other study(ies) available for pd-173212 and Seizures

Article	Year
Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorganic & medicinal chemistry letters, 1999, Aug-02, Volume: 9, Issue:15 Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown efficacy in several animal models of stroke and pain. In the process of searching for small molecule N-type calcium channel blockers, we have identified a series of N-methyl-N-aralkyl-peptidylamines with potent functional activity at N-type VSCCs. The most active compound discovered in this series is PD 173212 (11, IC50 = 36 nM in the IMR-32 assays). SAR and pharmacological evaluation of this series are described. Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dipeptides; Disease Models, Animal; Humans; Mice; Seizures; Structure-Activity Relationship; Tumor Cells, Cultured	1999

Article

Year

Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers.

Bioorganic & medicinal chemistry letters, 1999, Aug-02, Volume: 9, Issue:15

Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown efficacy in several animal models of stroke and pain. In the process of searching for small molecule N-type calcium channel blockers, we have identified a series of N-methyl-N-aralkyl-peptidylamines with potent functional activity at N-type VSCCs. The most active compound discovered in this series is PD 173212 (11, IC50 = 36 nM in the IMR-32 assays). SAR and pharmacological evaluation of this series are described.

Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dipeptides; Disease Models, Animal; Humans; Mice; Seizures; Structure-Activity Relationship; Tumor Cells, Cultured

1999