pd 173074 has been researched along with Pancreatic Neoplasms in 2 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Against the background of increasing acquired resistance to FGFR1 inhibitors and our previous work, which partially demonstrated the caspase-3/PARP-mediated antitumor and antimetastatic efficacy of PD173074, a selective FGFR1 inhibitor, against ALDH-high/FGFR1-rich pancreatic ductal adenocarcinoma (PDAC) cells, we investigated the probable synthetic lethality and therapeutic efficacy of targeted PARP inhibition combined with FGFR1 blockade in patients with PDAC." | 1.56 | Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer. ( Bamodu, OA; Chao, TY; Chen, JH; Lai, SW; Lee, WH; Wu, AT; Yeh, CT, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, SW | 1 |
| Bamodu, OA | 1 |
| Chen, JH | 1 |
| Wu, AT | 1 |
| Lee, WH | 1 |
| Chao, TY | 1 |
| Yeh, CT | 1 |
| Büchler, P | 1 |
| Reber, HA | 1 |
| Roth, MM | 1 |
| Shiroishi, M | 1 |
| Friess, H | 1 |
| Hines, OJ | 1 |
2 other studies available for pd 173074 and Pancreatic Neoplasms
| Article | Year |
|---|---|
Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer.
Topics: Animals; Cell Line, Tumor; Female; Humans; Mice; Pancreatic Neoplasms; Phthalazines; Piperazines; Po | 2020 |
Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Cycle; Cell Divi | 2007 |