pd 173074 has been researched along with Glioblastoma in 3 studies
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the FGFR inhibitor PD173074, the FAK inhibitors PF431396 and Y15 and the αvβ3/αvβ5 integrin inhibitor cilengitide were assessed in L1-positive and L1-negative variants of the human glioblastoma-derived cell lines T98G and U-118 MG." | 3.83 | Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation. ( Anderson, HJ; Galileo, DS, 2016) |
| "Inhibition of FGFR kinase corrects the aneuploidy, and oral administration of an FGFR inhibitor prolongs survival of mice harboring intracranial FGFR3-TACC3-initiated glioma." | 1.38 | Transforming fusions of FGFR and TACC genes in human glioblastoma. ( Aldape, K; Brat, DJ; Castano, A; Ceccarelli, M; Chan, JM; Finocchiaro, G; Gao, Z; Golfinos, JG; Guha, A; Iavarone, A; Lasorella, A; Liu, EM; Mikkelsen, T; Niola, F; Pellegatta, S; Porrati, P; Qiu, K; Rabadan, R; Reichel, J; Riccardi, R; Singh, D; Sullivan, R; Zagzag, D; Zoppoli, P, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, HJ | 1 |
| Galileo, DS | 1 |
| Loilome, W | 1 |
| Joshi, AD | 1 |
| ap Rhys, CM | 1 |
| Piccirillo, S | 1 |
| Vescovi, AL | 1 |
| Angelo, VL | 1 |
| Gallia, GL | 1 |
| Riggins, GJ | 1 |
| Singh, D | 1 |
| Chan, JM | 1 |
| Zoppoli, P | 1 |
| Niola, F | 1 |
| Sullivan, R | 1 |
| Castano, A | 1 |
| Liu, EM | 1 |
| Reichel, J | 1 |
| Porrati, P | 1 |
| Pellegatta, S | 1 |
| Qiu, K | 1 |
| Gao, Z | 1 |
| Ceccarelli, M | 1 |
| Riccardi, R | 1 |
| Brat, DJ | 1 |
| Guha, A | 1 |
| Aldape, K | 1 |
| Golfinos, JG | 1 |
| Zagzag, D | 1 |
| Mikkelsen, T | 1 |
| Finocchiaro, G | 1 |
| Lasorella, A | 1 |
| Rabadan, R | 1 |
| Iavarone, A | 1 |
3 other studies available for pd 173074 and Glioblastoma
| Article | Year |
|---|---|
Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation.
Topics: Aniline Compounds; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Pro | 2016 |
Glioblastoma cell growth is suppressed by disruption of Fibroblast Growth Factor pathway signaling.
Topics: Antibodies; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzym | 2009 |
Transforming fusions of FGFR and TACC genes in human glioblastoma.
Topics: Aneuploidy; Animals; Antineoplastic Agents; Benzamides; Brain Neoplasms; Cell Transformation, Neopla | 2012 |