pd 173074 has been researched along with Brain Neoplasms in 5 studies
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the FGFR inhibitor PD173074, the FAK inhibitors PF431396 and Y15 and the αvβ3/αvβ5 integrin inhibitor cilengitide were assessed in L1-positive and L1-negative variants of the human glioblastoma-derived cell lines T98G and U-118 MG." | 3.83 | Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation. ( Anderson, HJ; Galileo, DS, 2016) |
| "Inhibition of FGFR kinase corrects the aneuploidy, and oral administration of an FGFR inhibitor prolongs survival of mice harboring intracranial FGFR3-TACC3-initiated glioma." | 1.38 | Transforming fusions of FGFR and TACC genes in human glioblastoma. ( Aldape, K; Brat, DJ; Castano, A; Ceccarelli, M; Chan, JM; Finocchiaro, G; Gao, Z; Golfinos, JG; Guha, A; Iavarone, A; Lasorella, A; Liu, EM; Mikkelsen, T; Niola, F; Pellegatta, S; Porrati, P; Qiu, K; Rabadan, R; Reichel, J; Riccardi, R; Singh, D; Sullivan, R; Zagzag, D; Zoppoli, P, 2012) |
| "To validate this model in primary human pituitary tumors, we examined the expression of ptd-FGFR4, N-cadherin, and clinical behavior." | 1.33 | Targeting N-cadherin through fibroblast growth factor receptor-4: distinct pathogenetic and therapeutic implications. ( Asa, SL; Ezzat, S; Winer, D; Zheng, L, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, J | 1 |
| Benitez, JA | 1 |
| Li, J | 1 |
| Miki, S | 1 |
| Ponte de Albuquerque, C | 1 |
| Galatro, T | 1 |
| Orellana, L | 1 |
| Zanca, C | 1 |
| Reed, R | 1 |
| Boyer, A | 1 |
| Koga, T | 1 |
| Varki, NM | 1 |
| Fenton, TR | 1 |
| Nagahashi Marie, SK | 1 |
| Lindahl, E | 1 |
| Gahman, TC | 1 |
| Shiau, AK | 1 |
| Zhou, H | 1 |
| DeGroot, J | 1 |
| Sulman, EP | 1 |
| Cavenee, WK | 1 |
| Kolodner, RD | 1 |
| Chen, CC | 1 |
| Furnari, FB | 1 |
| Anderson, HJ | 1 |
| Galileo, DS | 2 |
| Singh, D | 1 |
| Chan, JM | 1 |
| Zoppoli, P | 1 |
| Niola, F | 1 |
| Sullivan, R | 1 |
| Castano, A | 1 |
| Liu, EM | 1 |
| Reichel, J | 1 |
| Porrati, P | 1 |
| Pellegatta, S | 1 |
| Qiu, K | 1 |
| Gao, Z | 1 |
| Ceccarelli, M | 1 |
| Riccardi, R | 1 |
| Brat, DJ | 1 |
| Guha, A | 1 |
| Aldape, K | 1 |
| Golfinos, JG | 1 |
| Zagzag, D | 1 |
| Mikkelsen, T | 1 |
| Finocchiaro, G | 1 |
| Lasorella, A | 1 |
| Rabadan, R | 1 |
| Iavarone, A | 1 |
| Mohanan, V | 1 |
| Temburni, MK | 1 |
| Kappes, JC | 1 |
| Ezzat, S | 1 |
| Zheng, L | 1 |
| Winer, D | 1 |
| Asa, SL | 1 |
5 other studies available for pd 173074 and Brain Neoplasms
| Article | Year |
|---|---|
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.
Topics: Animals; Brain Neoplasms; Cell Nucleus; DNA Repair; Female; Glioma; Humans; Male; Mice; Phosphorylat | 2019 |
Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation.
Topics: Aniline Compounds; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Pro | 2016 |
Transforming fusions of FGFR and TACC genes in human glioblastoma.
Topics: Aneuploidy; Animals; Antineoplastic Agents; Benzamides; Brain Neoplasms; Cell Transformation, Neopla | 2012 |
L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid Precursor Protein Secretases; Apoptosis; Blotting, Western; B | 2013 |
Targeting N-cadherin through fibroblast growth factor receptor-4: distinct pathogenetic and therapeutic implications.
Topics: Adenoma; Animals; Antineoplastic Agents; Brain Neoplasms; Cadherins; Cell Proliferation; Cells, Cult | 2006 |