pd 153035 has been researched along with Carcinoma, Epidermoid in 11 studies
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline: structure given in first source
PD-153035 : A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral squamous cell carcinoma (OSCC) is the sixth most common human neoplasm worldwide." | 1.38 | Therapeutic and preventive effects of an epidermal growth factor receptor inhibitor on oral squamous cell carcinoma. ( Fu, Z; Ge, H; Liu, H; Sun, Z, 2012) |
| "Human squamous cell carcinomas frequently overexpress the epidermal growth factor receptor (EGFR) and this is often associated with poor prognosis in patients with these cancers." | 1.30 | EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5. ( Affleck, K; Dean, C; Modjtahedi, H; Stubberfield, C, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (63.64) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rewcastle, GW | 1 |
| Palmer, BD | 1 |
| Bridges, AJ | 1 |
| Showalter, HD | 1 |
| Sun, L | 1 |
| Nelson, J | 1 |
| McMichael, A | 1 |
| Kraker, AJ | 1 |
| Fry, DW | 3 |
| Denny, WA | 1 |
| Sugiura, K | 1 |
| Muro, Y | 1 |
| Futamura, K | 1 |
| Matsumoto, K | 1 |
| Hashimoto, N | 1 |
| Nishizawa, Y | 1 |
| Nagasaka, T | 1 |
| Saito, H | 1 |
| Tomita, Y | 1 |
| Usukura, J | 1 |
| Ge, H | 1 |
| Liu, H | 1 |
| Fu, Z | 1 |
| Sun, Z | 1 |
| Li, M | 1 |
| Ye, C | 1 |
| Feng, C | 1 |
| Riedel, F | 1 |
| Liu, X | 1 |
| Zeng, Q | 1 |
| Grandis, JR | 1 |
| Kunkel, MW | 1 |
| Hook, KE | 1 |
| Howard, CT | 1 |
| Przybranowski, S | 1 |
| Roberts, BJ | 1 |
| Elliott, WL | 1 |
| Leopold, WR | 1 |
| Hagmann, W | 1 |
| Borgers, S | 1 |
| Nelson, JM | 1 |
| Modjtahedi, H | 1 |
| Affleck, K | 1 |
| Stubberfield, C | 1 |
| Dean, C | 1 |
| Bos, M | 1 |
| Mendelsohn, J | 1 |
| Kim, YM | 1 |
| Albanell, J | 1 |
| Baselga, J | 1 |
| Faust, RA | 1 |
| Tawfic, S | 1 |
| Davis, AT | 1 |
| Ahmed, K | 1 |
| Lichtner, RB | 1 |
| Menrad, A | 1 |
| Sommer, A | 1 |
| Klar, U | 1 |
| Schneider, MR | 1 |
11 other studies available for pd 153035 and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Binding Sites; Carcinoma, Squamous Cell; Cell Cycle; Cel | 1996 |
The unfolded protein response is activated in differentiating epidermal keratinocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; ATP-Binding Cassette Transporters; Carcinoma, Squamous C | 2009 |
Therapeutic and preventive effects of an epidermal growth factor receptor inhibitor on oral squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis | 2012 |
Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy.
Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Division; Cells, Cultured; Collagen; Down | 2002 |
Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice.
Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Enzyme Inhibitors; ErbB Receptors; Humans; Mice; M | 1996 |
Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells.
Topics: Arachidonate 12-Lipoxygenase; Biotin; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Do | 1997 |
Cytoskeletal and morphological changes associated with the specific suppression of the epidermal growth factor receptor tyrosine kinase activity in A431 human epidermoid carcinoma.
Topics: Actins; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Division; Cytoskeleton; Enzyme Inhib | 1997 |
EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.
Topics: Antibodies, Monoclonal; Apoptosis; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; En | 1998 |
PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Enzyme Inhibitors; Er | 1997 |
Apoptosis and growth inhibition of head and neck tumor cell line induced by epidermal growth factor receptor tyrosine kinase inhibitor.
Topics: Apoptosis; Carcinoma, Squamous Cell; Enzyme Inhibitors; ErbB Receptors; Gingival Neoplasms; Humans; | 1999 |
Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Enzyme In | 2001 |