pd 153035 has been researched along with Breast Cancer in 12 studies
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline: structure given in first source
PD-153035 : A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indole-3-carbinol (I3C) is a promising anticancer dietary compound, which inhibits breast cancer in animal models." | 3.73 | Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. ( Fox, LH; Howells, LM; Manson, MM; Moiseeva, EP; Temple, LA, 2006) |
| "Present study utilized several human breast cancer cell lines (MCF-7, T-47D, Hs578T and MDA-MB-231, varying in COX-2 expression) as well as 10 human breast cancer specimens to examine the roles of COX-2 and prostaglandin E (EP) receptors in VEGF-C expression or secretion, and the relationship of COX-2 or VEGF-C expression to lymphangiogenesis." | 1.33 | COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. ( Chakraborty, C; Lala, PK; Timoshenko, AV; Wagner, GF, 2006) |
| "Because the prostate and breast cancer lines usually present autocrine stimulatory loops involving EGFR, we also examined transgenic adenocarcinoma mouse prostate C1 and MDA-468 treated with the EGFR-specific kinase inhibitor PD153035 to determine whether invasiveness is dependent on EGFR signaling." | 1.30 | A role for phospholipase C-gamma-mediated signaling in tumor cell invasion. ( Greenberg, NM; Kassis, J; Kim, HG; Lo, H; Moellinger, J; Wells, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xing, RC | 1 |
| Zheng, J | 1 |
| Zheng, WH | 1 |
| Qin, ZP | 1 |
| Liu, W | 1 |
| Yao, RC | 1 |
| Rae, JM | 1 |
| Lippman, ME | 1 |
| Grunt, TW | 3 |
| Puckmair, K | 3 |
| Tomek, K | 3 |
| Kainz, B | 2 |
| Gaiger, A | 2 |
| Moiseeva, EP | 1 |
| Fox, LH | 1 |
| Howells, LM | 1 |
| Temple, LA | 1 |
| Manson, MM | 1 |
| Timoshenko, AV | 1 |
| Chakraborty, C | 1 |
| Wagner, GF | 1 |
| Lala, PK | 1 |
| Wagner, R | 2 |
| Rünzler, D | 1 |
| Köhler, G | 1 |
| Zielinski, CC | 2 |
| Kondapaka, SB | 1 |
| Fridman, R | 1 |
| Reddy, KB | 1 |
| Bos, M | 1 |
| Mendelsohn, J | 1 |
| Kim, YM | 1 |
| Albanell, J | 1 |
| Fry, DW | 1 |
| Baselga, J | 1 |
| Kassis, J | 1 |
| Moellinger, J | 1 |
| Lo, H | 1 |
| Greenberg, NM | 1 |
| Kim, HG | 1 |
| Wells, A | 1 |
| Lichtner, RB | 1 |
| Menrad, A | 1 |
| Sommer, A | 1 |
| Klar, U | 1 |
| Schneider, MR | 1 |
| Li, L | 1 |
| Shaw, PE | 1 |
12 other studies available for pd 153035 and Breast Cancer
| Article | Year |
|---|---|
Relevance of E-cadherin expression to EGFR-TKI molecular targeted therapy sensitivity/resistance and its clinical significance.
Topics: Breast Neoplasms; Cadherins; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Gefitini | 2015 |
Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Enzyme Inhibitors; ErbB Re | 2004 |
An EGF receptor inhibitor induces RAR-beta expression in breast and ovarian cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; ErbB Receptors; Female; G | 2005 |
Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment.
Topics: Adenosine Triphosphate; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Caspase Inhibitors; Caspa | 2006 |
COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Down-Regulation; En | 2006 |
Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; CpG Islands; DNA Methylati | 2007 |
The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; DNA; ErbB Receptors; Genes, Tumor Suppr | 2007 |
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells.
Topics: Amphiregulin; Antineoplastic Agents; Breast Neoplasms; Cell Division; Collagenases; EGF Family of Pr | 1997 |
PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Enzyme Inhibitors; Er | 1997 |
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Topics: Adenocarcinoma; Animals; Autocrine Communication; Breast Neoplasms; Cell Line; Diffusion Chambers, C | 1999 |
Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Enzyme In | 2001 |
Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.
Topics: Breast Neoplasms; Cell Division; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Female; | 2002 |