pd 153035 has been researched along with Brain Neoplasms in 3 studies
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline: structure given in first source
PD-153035 : A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glioblastoma (GB) is the most frequent primary brain tumor in adults with a dismal prognosis despite aggressive treatment including surgical resection, radiotherapy and chemotherapy with the alkylating agent temozolomide." | 2.87 | Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma. ( Harter, PN; Mittelbronn, M; Pietsch, T; Reuter, D; Ronellenfitsch, MW; Senft, C; Steinbach, JP; Urban, H; Westphal, M; Zeiner, PS, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ronellenfitsch, MW | 1 |
| Zeiner, PS | 1 |
| Mittelbronn, M | 1 |
| Urban, H | 1 |
| Pietsch, T | 1 |
| Reuter, D | 1 |
| Senft, C | 1 |
| Steinbach, JP | 2 |
| Westphal, M | 1 |
| Harter, PN | 1 |
| Wang, H | 1 |
| Yu, JM | 1 |
| Song, XR | 1 |
| Yang, GR | 1 |
| Mu, DB | 1 |
| Zhao, SQ | 1 |
| Wang, XW | 1 |
| Wei, L | 1 |
| Liu, YL | 1 |
| Song, B | 1 |
| Fu, Z | 1 |
| Teng, XP | 1 |
| Eisenmann, C | 1 |
| Klumpp, A | 1 |
| Weller, M | 1 |
1 trial available for pd 153035 and Brain Neoplasms
| Article | Year |
|---|---|
Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma.
Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal, Humanized; Basic Helix-Loop-Helix Tran | 2018 |
2 other studies available for pd 153035 and Brain Neoplasms
| Article | Year |
|---|---|
[Molecular imaging of epidermal growth factor receptor in glioma-bearing rats].
Topics: Animals; Brain Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Gastrointestinal T | 2008 |
Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis.
Topics: Apoptosis; Brain Neoplasms; Caspase 8; Caspases; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors | 2004 |