pd-150606 and Cardiomegaly

pd-150606 has been researched along with Cardiomegaly* in 1 studies

Other Studies

1 other study(ies) available for pd-150606 and Cardiomegaly

ArticleYear
Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes.
    Molecular and cellular biochemistry, 2003, Volume: 251, Issue:1-2

    Two inhibitors of the calcium-dependent cysteine protease, calpain, have markedly different effects on the extent of hypertrophy induced by the alpha-adrenergic agonist, phenylephrine, of cultured neonatal rat ventricular myocytes. E64c, an inhibitor of calpain and other cysteine proteases, stimulated the hypertrophy by 59%. PD 150606, a specific calpain inhibitor, reduced the hypertrophy by 38%. Phenylephrine decreased the proteolysis of a calpain substrate by the cells 1-2 h after its addition but not at 24 h. PD 150606 inhibited proteolytic activity at all times, and the combination of phenylephrine and PD 150606 did not give greater inhibition. This suggests that cysteine proteases of the papain sub-family are involved with the hypertrophic response at two points, promoting hypertrophy at the first and limiting it at the second. Calpain appears to be the protease involved at the first point, and there may be another cysteine protease acting at the second site.

    Topics: Acrylates; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calpain; Cardiomegaly; Cells, Cultured; Cysteine Proteinase Inhibitors; Glycoproteins; Heart Ventricles; Leucine; Myocytes, Cardiac; Phenylephrine; Rats; Time Factors; Ventricular Function, Left

2003