pd-124895 and Leukemia-P388

pd-124895 has been researched along with Leukemia-P388* in 2 studies

Other Studies

2 other study(ies) available for pd-124895 and Leukemia-P388

Article	Year
[Studies on the new antibiotic kazusamycin and related substances]. Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:3 Pt 2 Kazusamycins A and B and leptomycin B have a structure characteristic of an unsaturated, branched-chain fatty acid with a terminal delta-lactone ring, and show antibacterial activity on some kinds of fungi. Kazusamycin A (KZM-A) showed cytotoxic activity on mammalian cells at very low concentrations (ng/ml) in vitro. The antibiotic inhibited not only the growth of transplantable murine tumors and their metastases to the lung but also human mammary tumors inoculated into nude mice. KZM-A became immediately distributed to the main organs of mice, and a certain quantity of the antibiotic was inactivated by binding to high-molecular-weight substances such as albumin. A large quantity of KZM-A was carried to the liver and excreted into the bile, but was then reabsorbed by the small intestine. The growth of tumor metastases (L5178Y cells) in the liver was suppressed by KZM-A. The antibiotic induced severe diarrhea by causing necrosis and/or lysis of the mucous membrane of the small intestine. In contrast to this, the degree of myelotoxicity was relatively slight. The active site of the fatty acid of KZM-A appeared to consist of conjugated double bonds, carboxylic acid and hydroxyl moieties. Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Fatty Acids, Unsaturated; Kinetics; Leukemia P388; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental	1987
Kazusamycin B, a novel antitumor antibiotic. The Journal of antibiotics, 1987, Volume: 40, Issue:6 A novel antibiotic, kazusamycin B (C32H46O7, MW 542), was isolated from the fermentation broth of Streptomyces sp. No. 81-484 and the structure was established mainly on the basis of its physico-chemical properties. Unambiguous 13C NMR spectral analysis of kazusamycin B has been also accomplished. Kazusamycin B possesses potent cytocidal activities against L1210 (IC50 0.0018 micrograms/ml) and P388 (IC100 0.0016 micrograms/ml) leukemia cells in vitro. Topics: Animals; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Fatty Acids, Unsaturated; Fermentation; Fungi; Leukemia L1210; Leukemia P388; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry; Streptomyces	1987

Article

Year

[Studies on the new antibiotic kazusamycin and related substances].

Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:3 Pt 2

Kazusamycins A and B and leptomycin B have a structure characteristic of an unsaturated, branched-chain fatty acid with a terminal delta-lactone ring, and show antibacterial activity on some kinds of fungi. Kazusamycin A (KZM-A) showed cytotoxic activity on mammalian cells at very low concentrations (ng/ml) in vitro. The antibiotic inhibited not only the growth of transplantable murine tumors and their metastases to the lung but also human mammary tumors inoculated into nude mice. KZM-A became immediately distributed to the main organs of mice, and a certain quantity of the antibiotic was inactivated by binding to high-molecular-weight substances such as albumin. A large quantity of KZM-A was carried to the liver and excreted into the bile, but was then reabsorbed by the small intestine. The growth of tumor metastases (L5178Y cells) in the liver was suppressed by KZM-A. The antibiotic induced severe diarrhea by causing necrosis and/or lysis of the mucous membrane of the small intestine. In contrast to this, the degree of myelotoxicity was relatively slight. The active site of the fatty acid of KZM-A appeared to consist of conjugated double bonds, carboxylic acid and hydroxyl moieties.

Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Fatty Acids, Unsaturated; Kinetics; Leukemia P388; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental

1987

Kazusamycin B, a novel antitumor antibiotic.

The Journal of antibiotics, 1987, Volume: 40, Issue:6

A novel antibiotic, kazusamycin B (C32H46O7, MW 542), was isolated from the fermentation broth of Streptomyces sp. No. 81-484 and the structure was established mainly on the basis of its physico-chemical properties. Unambiguous 13C NMR spectral analysis of kazusamycin B has been also accomplished. Kazusamycin B possesses potent cytocidal activities against L1210 (IC50 0.0018 micrograms/ml) and P388 (IC100 0.0016 micrograms/ml) leukemia cells in vitro.

Topics: Animals; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Fatty Acids, Unsaturated; Fermentation; Fungi; Leukemia L1210; Leukemia P388; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry; Streptomyces

1987