pd-114-721 has been researched along with Melanoma* in 2 studies
2 other study(ies) available for pd-114-721 and Melanoma
| Article | Year |
|---|---|
The effect of kazusamycin on the growth of murine solid tumors and their spontaneous metastasis.
Topics: Animals; Antibiotics, Antineoplastic; Fatty Acids, Unsaturated; Female; Lung Neoplasms; Melanoma; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental | 1987 |
Antitumor activity of a new antibiotic, kazusamycin.
The antitumor activity of a new antibiotic, kazusamycin, against various murine tumors was studied by various treatment schedules. Single, intermittent, and successive injections of the antibiotic were almost equally effective against Ehrlich carcinoma, IMC carcinoma and sarcoma 180 tumor, but successive injections showed more efficacy than the other schedules against Meth A fibrosarcoma and Lewis lung carcinoma. Interestingly, there was no clear dose response for the efficacy of kazusamycin on murine tumors. When HeLa cells were exposed to kazusamycin for 72 hours in vitro, the IC50 value was about 1 ng/ml, however the cytotoxicity of the antibiotic depended on the incubation time. Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Ehrlich Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated; HeLa Cells; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms, Experimental; Sarcoma 180 | 1985 |