pd-0325901 and Pruritus

Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the mechanisms underlying the dermatological abnormalities remain unclear. Here, we demonstrated that knock-in mice expressing an Hras G12S mutation (Hras

Topics: Animals; Benzamides; Cell Proliferation; Costello Syndrome; Cytokines; Dermatitis, Atopic; Diphenylamine; Disease Models, Animal; Disease Susceptibility; Ear; Epidermis; Inflammation Mediators; Interleukin-33; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Pruritus; Pyroglyphidae