pci-34051 and Triple-Negative-Breast-Neoplasms

Triple-negative breast cancer (TNBC) shows highly aggressive clinical behaviors and poor prognosis compared to other breast cancer subtypes. Histone deacetylases (HDACs) can regulate the progression of various cancers, but the role of HDAC8 in TNBC remains unexplored. Here, we found that HDAC8 enhanced the in vitro migration abilities of breast cancer cells. Targeted inhibition of HDAC8 via si-HDAC8 and its selective inhibitor PCI34051 could suppress the migration of cells. In TNBC cells, HDAC8 stabilized the expression and increased the nuclear localization of YAP, a major downstream effector of Hippo pathway. While silencing YAP could attenuate HDAC8 triggered migration of TNBC cells. Mechanistically, HDAC8 suppressed the phosphorylation of YAP

Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Cell Movement; Female; Histone Deacetylases; Humans; Hydroxamic Acids; Indoles; Phosphoproteins; Phosphorylation; Repressor Proteins; Signal Transduction; Transcription Factors; Triple Negative Breast Neoplasms; YAP-Signaling Proteins