pci-34051 and Heart-Failure

Heart failure is characterized by activation of the renin-angiotensin-aldosterone system, which is involved in the regulation of cardiac hypertrophy and hypertension. Recently, we reported that Hdac8 inhibition alleviates isoproterenol-induced and angiotensin II-induced cardiac hypertrophy or hypertension in mice. Here, the effect and regulatory mechanisms of the Hdac8 selective inhibitor PCI34051 on pressure overload-induced heart failure were examined.. Treatment with PCI34051 enhanced cardiac and lung functions in the TAC-induced heart failure mouse model. These data suggest that HDAC8 is a potential novel therapeutic target for heart failure accompanied by pathological lung diseases.

Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Down-Regulation; Fibroblasts; Heart Failure; Histone Deacetylases; Hydroxamic Acids; Indoles; Male; Mice; Mice, Inbred ICR; Myocardium; Myocytes, Cardiac; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta1