pci-32765 and Retinal-Detachment

To report a case of serous macular detachment in a patient with Waldenstrom macroglobulinemia treated with ibrutinib.. The patient underwent a complete ophthalmic examination and imaging at presentation and at follow-up visits up to 13 months.. At presentation, there were serous macular detachments bilaterally with no dye leakage on fluorescein angiography or vasculature abnormalities on optical coherence tomography angiography. After treatment with ibrutinib, there was near resolution of the patient's retinopathy with an improvement in vision at 13 months' follow-up.. Serous macular detachments in Waldenstrom macroglobulinemia-associated retinopathy may be due to the disruption of the retinal pigment epithelium pump mechanism by hyperglobulinemia. The favorable course of this patient, treated with the novel tyrosine kinase inhibitor ibrutinib, suggests this may be the preferred treatment for Waldenstrom macroglobulinemia patients with associated retinopathy.

Topics: Adenine; Humans; Piperidines; Retinal Detachment; Treatment Outcome; Waldenstrom Macroglobulinemia